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Transport asymmetry in peritoneal dialysis: application of a serial heteroporous peritoneal membrane model

The transport of macromolecules during peritoneal dialysis is highly selective when they move from blood to dialysate but nearly completely unselective in the opposite direction. Aiming at describing this asymmetry, we modeled the peritoneal barrier as a series arrangement of two heteroporous membranes. First a three-pore membrane was considered, crossed by small [radius of the small pore (r(s)) a

Patients with heart failure in primary health care: effects of a nurse-led intervention on health-related quality of life and depression

Aims: To determine the effects of a nurse-led intervention designed to improve self-management of patients with heart failure in a primary health care setting regarding health-related quality of life and depression. Methods: Patients at eight primary health care centres were screened by the Diagnosis Related Groups registry for the diagnosis of heart failure and eligibility for a cluster randomise

Bacterial magnetite in Swedish varved lake-sediments: a potential bio-marker of environmental change

Detailed mineral magnetic measurements were carried out on three varved lake-sediment sequences in Sweden, which extend to ca. 7000 BC. The comparison of the magnetic properties of the organic rich varved lake-sediments with their respective catchment materials indicates that the magnetic properties of the sediments are dominated by relatively high concentrations of single-domain magnetite magneto

Identification of novel phosphorylation sites in hormone-sensitive lipase that are phosphorylated in response to isoproterenol and govern activation properties in vitro

Hormone-sensitive lipase (HSL) is the rate-limiting enzyme in lipolysis. Stimulation of rat adipocytes with isoproterenol results in phosphorylation of HSL and a 50-fold increase in the rate of lipolysis. In this study, we used site-directed mutagenesis and two-dimensional phosphopeptide mapping to show that phosphorylation sites other than the previously identified Ser-563 are phosphorylated in H

Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study.

Aims/hypothesis: Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Methods: Plasma concentrations of C3 and complement factor 4 (C4) were measured in

Large Footprint Pyrene Chromophores Anchored to Planar and Colloidal Metal Oxide Thin Films

Sensitization and binding of a large footprint pyrene chromophore to planar (sapphire) and colloidal metal oxide films (TiO2 and ZrO2) is investigated. The model compound combines a 1-pyrenyl-ethynylenephenylene unit with a new adamantane-tripodal linker that binds to the surface. The linker design, combining a large footprint (2 nm2) of the tripodal linker with the meta position of the COOH ancho

Women's informed choice of prenatal diagnosis: early ultrasound examination-routine ultrasound examination-age-independent amniocentesis

The antenatal clinics in the catchment area of the Department of Obstetrics and Gynecology, University Hospital, Lund, were divided into a study group and a control group. At the study antenatal clinics during a 15-month period 1,004 pregnant women received a written and verbal information that a routine ultrasound examination during gestational week 18 should be considered as a prenatal diagnosti

Terrestrial trophic dynamics in the Canadian Arctic

The Swedish Tundra Northwest Expedition of 1999 visited 17 sites throughout the Canadian Arctic. At 12 sites that were intensively sampled we estimated the standing crop of plants and the densities of herbivores and predators with an array of trapping, visual surveys, and faecal-pellet transects. We developed a trophic-balance model using ECOPATH to integrate these observations and determine the f

Montelukast in the treatment of asthma and beyond

Asthma is a chronic inflammatory disease affecting over 300 million people worldwide. The common association with allergic rhinitis and the presence of proinflammatory cells and mediators in the circulation of patients qualify asthma as a systemic disease. This characteristic and the fact that the gold-standard therapy for persistent asthma, inhaled corticosteroids, cannot suppress all components

Effects of dopamine on porcine myocardial action potentials and contractions at 37 degrees C and 32 degrees C

BACKGROUND: Little information exists on the effects of drugs with cardiovascular action in hypothermia, and some findings have indicated paradoxic effects of dopamine in this setting. As we have not found any data on the electrophysiologic and contractile effects of dopamine on the heart in hypothermia, we decided to study this in pig myocardium, since pigs have a cardiovascular system more simil

Generating visible single photons on demand with single InP quantum dots

We present photon correlation measurements performed on a device based on single InP quantum dots. The device consists of a 400 nm thick membrane containing a low density of quantum dots on a metal mirror. Measurements done under continuous excitation reveal a very pronounced antibunching dip while measurements done under pulsed excitation enable the generation of single photons on demand at the o

Diktaren i medieåldern: Om relationen mellan film och lyrik i Bruno K. Öijers verk

ag arbetar för närvarande på ett projekt om relationer mellan film och lyrik. Detta är ett tämligen outforskat område, inte minst vad gäller fenomenet ”den filmatiserade diktsamlingen”. vanligtvis diskuteras och undersöks prosaberättelsens relation till filmmediet, och mer sällan lyrikens dito. I mitt paper kommer jag att behandla två aspekter: poesi på/i film, samt filmanknytningar i lyrik. Mitt

Cubic phase nanoparticles (Cubosome): Principles for controlling size, structure, and stability

Methods and compositions for producing lipid-based cubic phase nanoparticles were first discovered in the 1990s. Since then a number of studies have been presented, but little is known about how to control key properties such as particle size, morphology, and stability of cubic phase dispersions. In the present work we give examples of how these properties can be tuned by composition and processin

Placental Doppler velocimetry in gestational diabetes mellitus

Objective: To evaluate if maternal glucose level and growth of the fetus were related to placental vascular impedance in pregnancy complicated by gestational diabetes mellitus. Material and methods: A retrospective study of 146 gestational diabetic women of which 117 needed insulin therapy. Glycosylated hemoglobin (HbA(1c)) was evaluated as well as umbilical and uterine artery Doppler velocimetry.

Immunomodulation of Atherosclerosis. Implications for Vaccine Development.

A number of studies have shown activation of the immune system throughout various stages of atherosclerosis. Recent observations have suggested that activation of immune responses may promote atherosclerosis on one hand by inducing and perpetuating arterial inflammation, whereas on the other hand, selective activation of certain immune functions may inhibit atherosclerosis and arterial inflammatio

Hay fever and a single intramuscular injection of corticosteroid: a systematic review

Objectives: In severe hay fever, some patients are strongly affected despite the use of first-line therapy and are therefore treated with an intramuscular injection of systemic corticosteroid (i.m. SCS) in some countries. The aim of this paper was to explore the efficacy and side effects of a single i.m. SCS injection in hay fever in adults. Data sources: PubMed, EMBASE, Cochrane Library. Method

Experimental crosses within European Silene latifolia (Caryophyllaceae): intraspecific differentiation, distance effects, and sex ratio

The dioecious weed Silene latifolia Poiret is thought to have spread northwards through Europe from separate southern source populations and shows a pronounced east–west pattern of differentiation in seed morphology. We used crossing experiments to investigate whether patterns of interfertility in S. latifolia are consistent with a scenario of ongoing speciation (reflected by outbreeding depressio