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High hyperdiploid acute lymphoblastic leukemia (HeH ALL), one of the most common childhood malignancies, is driven by nonrandom aneuploidy (abnormal chromosome numbers) mainly comprising chromosomal gains. In this study, we investigate how aneuploidy in HeH ALL arises. Single cell whole genome sequencing of 2847 cells from nine primary cases and one normal bone marrow reveals that HeH ALL generall

HyperSurfaces (HSFs) comprise structurally reconfigurable metasurfaces whose electromagnetic properties can be changed via a software interface, using an embed- ded miniaturized network of controllers, enabling novel capabilities in wireless communications, including 5G applications. Resource constraints associated with a hardware testbed of this breakthrough technology, currently under developmen

Syftet med detta examensarbete är att vidareutveckla en analysmodell inom deformationslokalisering för att få en bredare kunskap om det mekaniska beteendet hos ett geomaterial. Undersökning av lokala egenskaper hos ett jordprov kräver en fullfältsmätnin-gsteknik som i detta arbete är ultraljudstomografi. Anvädning av ultraljudtomografi inom ramarna av geomekanik har med tiden påvisat goda result

Human activities in coastal areas have intensified over the last 200 years, impacting also high-latitude regions such as the Baltic Sea. Benthic foraminifera, protists often with calcite shells (tests), are typically well preserved in marine sediments and known to record past bottom-water conditions. Morphological analyses of marine shells acquired by microcomputed tomography (µCT) have made signi

Technological developments now make it possible to employ many markers for many individuals in a phylogeographic setting, even for taxa with large and complex genomes such as salamanders. The banded newt (genus Ommatotriton) from the Near East has been proposed to contain three species (O. nesterovi, O. ophryticus and O. vittatus) with unclear phylogenetic relationships, apparently limited intersp

The genome of the Belinda variety of the hexaploid oat (Avena sativa) has recently been sequenced and assembled. This project aims to improve the assembly by clustering the thousands of scaffolds into their three ancestral subgenomes using Principle Component Analysis (PCA) of kmer and repeat-element frequencies. The method was developed using a chromosome level assembly of hexaploid Wheat (Tritiu

Why was the British Parliament so late in broadcasting its debates? Scholars have made recommendations on parliamentary communication, analysed its effects, and described the debates and arguments on broadcasting parliament. But who was making these arguments, and what role did parliamentarians’ identities play in these debates? We show the crucial role that partisanship—but also the distinctions

We performed 2 surveys during 2022 to estimate point prevalences of SARS-CoV-2 infection compared with overall viral seroprevalence in Sweden. Point prevalence was 1.4% in March and 1.5% in September. Estimated seroprevalence was >80%, including among unvaccinated children. Continued SARS-CoV-2 surveillance is necessary for detecting emerging, possibly more pathogenic variants.

Context: DevOps has recently become a mainstream solution for bridging the gaps between development (Dev) and operations (Ops) enabling cross-functional collaboration. The DevOps concept of continuous monitoring may bring a lot of benefits to development teams such as early detection of run-time errors and various performance anomalies. Objective: We aim to explore deep learning (DL) solutions for

Nanowires are explored as basic components for a large range of electronic devices. The nanowire format offersseveral benefits, including reduced material consumption and increased potential for combining materials to formnew novel heterostructures. Several factors, such as mechanical stress from contacting or a lattice mismatch in aheterostructure, can strain and change the lattice tilt. The stra

BACKGROUND: Transportation noise increases the risk of ischemic heart disease (IHD), but few studies have investigated subtypes of IHD, such as myocardial infarction (MI), angina pectoris, or heart failure. We aimed to study whether exposure to road, railway and aircraft noise increased risk for ischemic heart disease (IHD), IHD subtypes, and heart failure in the entire adult Danish population, in

FavoritesPermissionsORIGINAL ARTICLE: NUTRITIONFeeding Problems in Young Children: A Cross-Sectional Study in SwedenObjectives: To describe the prevalence of feeding problems (FPs) in children aged 10, 18, and 36 months who visited Swedish Child Health Services.Methods: Parents of children attending regular 10-, 18-, and 36-month visits at the child health care centers (CHCCs) in Sweden answered a

BackgroundGlobally, the COVID-19 pandemic had a huge impact on patients and healthcare systems. A decline in paediatric visits to healthcare settings was observed, which might have been due to lower incidence of injury and infectious illness, changes in healthcare services and parental concern. The aim of our study was to examine parental experiences of help-seeking for, and care of, a sick or inj

For more than a century the research on the Antikythera Mechanism engaged scientists from a widerange of scientific disciplines searching for clues, in order to solve the mystery that this unique ar-chaeological find poses. The results so far have been spectacular enough to re-write the History ofTechnology providing new aspects on the degree of technological sophistication and scientific de-velop