The reasons for enhanced deposition of extracellular matrix in the airways of asthmatic patients and the subsequent consequences on lung function are uncertain. Here, we investigated the synthesis of procollagen I and proteoglycans, the activity of various metalloproteinases (MMPs) and the production of their inhibitor TIMP-1 in biopsy-derived bronchial fibroblasts from eight patients with stable

Abstract in French Une analyse de serie chronologique nous sert a evaluer les effets de la temperature et de la densite sur les fluctuations des recoltes d'ecrevisses adultes de grande taille. Nous verifions si la temperature durant les differents stades du cycle biologique des ecrevisses influence les recoltes observees entre 1946 et 2007 dans le lac Bunn (Suede). De 1946 a 1974, l'ecrevisse a pi

The Mendelian Society in Lund was founded in 1910. The initiative came from two young biologists supported by a wide circle of interested plant breeders and academics. Already from the start the society was dominated by the towering personality Herman Nilsson-Ehle. After two active years, the Society went into temporal hibernation until it resumed its activities in spring 1916, when Nilsson-Ehle w

Degenerative changes of the lumbar spine may lead to misinterpretation of bone mineral density (BMD) measurements and cause underdiagnosis of osteoporosis. This longitudinal study of 1,044 women, 75 years at inclusion and followed for 10 years, shows that identification of apparent degenerative changes on the dual energy X-ray absorptiometry (DXA) scan can increase the proportion diagnosed. INTR

Bullous pemphigoid (BP) and epidermolysis bullosa acquisita are subepidermal autoimmune blistering diseases mediated by autoantibodies against type XVII collagen (Col17) and Col7, respectively. For blister formation, Fc-mediated events, such as infiltration of inflammatory cells in the skin, complement activation, and release of proteases at the dermal-epidermal junction, are essential. Although i

Published studies have shown that familial risks in the primary central nervous system (CNS) tumors are usually histology-specific. If genetic factors indeed determine tumor histology it would be expected that histological types would agree between affected first-degree relatives (FDRs).

OBJECTIVE: Knowledge about the impact of cardiovascular disease on cerebral autoregulation and cognition in aging is sparse. The aim of our study is to examine the association between cerebral blood flow (CBF), silent ST segment depression (STDE) on ambulatory ECG (LTER) and nocturnal blood pressure variations in elderly men. METHODS: In a cross-sectional cohort study "Men born in 1914", eighty 83

Purpose of review Despite guideline-based treatment, many patients with severe asthma continue to have uncontrolled disease. Fungal allergy is being increasingly recognized in the pathogenesis of severe asthma. Limited data exist on the approach to treatment of fungal asthma. This review summarizes existing evidence on the use of antifungal agents in allergic bronchopulmonary aspergillosis (ABPA)

Most of the world's animals are active in dim light and depend on good vision for the tasks of daily life. Many have evolved visual adaptations that permit a performance superior to that of manmade imaging devices [1]. In insects, a major model visual system, nocturnal species show impressive visual abilities ranging from flight control [2, 3], to color discrimination [4, 5], to navigation using v

Four new monophyletic groups are found within the teloschistoid clade of the subfamily Xanthorioideae in the Teloschistaceae using nuclear (ITS1/ITS2) and mitochondrial (12S mtSSU gene) DNA sequences. These groups are proposed as new genera: Brownliella gen. nova for the widely distributed Caloplaca cinnabarina group, Filsoniana gen. nova for the Australian Ca loplaca australiensis group, Fulgogas

The DNA structure in phage capsids is determined by DNA-DNA interactions and bending energy. The effects of repulsive interactions on DNA interaxial distance were previously investigated, but not the effect of DNA bending on its structure in viral capsids. By varying packaged DNA length and through addition of spermine ions, we transform the interaction energy from net repulsive to net attractive.

Cytomegalovirus (CMV) is a virus that causes chronic infections in a large set of the population. It may cause severe disease in immunocompromised individuals, is linked to immunosenescence and implied to play an important role in the pathogenesis of cardiovascular diseases and cancer. Modulation of the immune system's abilities to manage the virus represent a highly viable therapeutic option and

By paying particular attention to the local economic context, this paper analyzes the factors that influence rural non-agricultural employment and earnings. The empirical analysis is based on the Brazilian Demographic Census, allowing for disaggregated controls for the local economy. Education stands out as one of the key factors that shape employment outcome and earnings potential. Failure to con

The constitutive model for glassy polymers proposed by Arruda and Boyce (BPA model) is reviewed and compared to experimental data for long-term loading. The BPA model has previously been shown to capture monotonic loading accurately, but for unloading and long-term behavior, the response of the BPA model is found to deviate from experimental data. In the present paper, we suggest an efficient exte

Aims/hypothesis Some studies have revealed a relationship between Caesarean section (CS) and type 1 diabetes, while other studies have not. By using the Swedish paediatric quality register we investigated whether birth by CS is related to the risk of developing type 1 diabetes during childhood. Methods All children diagnosed with type 1 diabetes from 2000 to 2012 and included in the register (n= 9