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Andfåddhet potentiellt allvarligt – kräver strukturerad utredning

Andfåddhet är en subjektiv upplevelse och utgör ett ospecifikt, vanligt och potentiellt allvarligt symtom som tidigt bör utredas strukturerat tills orsaken är klarlagd, med fokus på att utesluta allvarliga differentialdiagnoser.Ökad medvetenhet om allvarlighetsgraden av andfåddhet kan minska fördröjning till diagnos samt förbättra prognosen, inte minst vid sällsynta sjukdomar såsom PAH (pulmonell Dyspnea is a common distressing symptom which may be a sign of a critically threatening condition and has been linked with increased hospitalizations, reduced exercise tolerance and increased mortality. The current neuropsychological model suggests that dyspnea arises due to an imbalance between respiratory drive and achieved ventilation. Pulmonary arterial hypertension (PAH) and chronic thromboem

Plant-Based Meat Analogues from Alternative Protein : A Systematic Literature Review

This study aimed to conduct a systematic literature review (SLR) of the research performed in the plant-based meat analogues area. Historical, current, and future tendencies are discussed. The paper offers a comprehensive SLR coupled with a bibliometric analysis of the publication from 1972 to January 2022. The articles were obtained using a research string and precise inclusion and exclusion crit

Validation and Cultural Adaptation of the Parent Attitudes about Childhood Vaccines (PACV) Questionnaire in Arabic Language Widely Spoken in a Region with a High Prevalence of COVID-19 Vaccine Hesitancy

The parents’ attitude toward vaccinating children and adolescents against coronavirus disease 2019 (COVID-19) remains inconsistent and needs further elucidation. The high rates of COVID-19 vaccine hesitancy in the Middle East and North Africa (MENA) region require intensive research to understand the determinants of this phenomenon. This study aimed to validate a version of the Parent Attitudes ab

Knowledge and Awareness of Algerian Students about Cervical Cancer, HPV and HPV Vaccines : A Cross-Sectional Study

Cervical cancer is one of the most recurrent and dangerous female cancers in Algeria and worldwide. It is mainly caused by human papillomaviruses (HPV), which can induce other cancers as well. Although it can be fatal, cervical cancer is one of the most preventable and manageable cancers. While HPV vaccination is the key weapon to win the battle against this pathology, it is still not approved in

VERTEX-REINFORCED JUMP PROCESS ON THE INTEGERS WITH NONLINEAR REINFORCEMENT

We consider a nonlinear vertex-reinforced jump process (VRJP(w)) on Z with an increasing measurable weight function w : [1, ∞) → [1, ∞) and initial weights equal to one. Our main goal is to study the asymptotic behaviour of VRJP(w) depending on the integrability of the reciprocal of w. In particular, we prove that if (Equation presented). then the process is recurrent, that is, it visits each vert

Light-front approach to axial-vector quarkonium γ * γ * form factors

In this work, we perform a detailed study of transition form factors for axial- vector meson production via the two-photon fusion process γ*γ* → 1++, with space-like virtual photons in the initial state and a P-wave axial-vector quarkonium in the final state. In this analysis, we employ the formalism of light-front quarkonium wave functions obtained from a solution of the Schrödinger equation for

Nomenclature and Definition of Atrophic Lesions in Small Bowel Capsule Endoscopy : A Delphi Consensus Statement of the International CApsule endoscopy REsearch (I-CARE) Group

(1) Background: Villous atrophy is an indication for small bowel capsule endoscopy (SBCE). However, SBCE findings are not described uniformly and atrophic features are sometimes not recognized; (2) Methods: The Delphi technique was employed to reach agreement among a panel of SBCE experts. The nomenclature and definitions of SBCE lesions suggesting the presence of atrophy were decided in a core gr

Tackling Mantle Cell Lymphoma in Europe

An expert panel convened by the European Alliance for Personalized Medicine (EAPM) reflected on achievements and outstanding challenges in Europe in mantle cell lymphoma (MCL). Through the prism of member state experience, the panel noted advances in outcomes over the last decade, but highlighted issues constituting barriers to better care. The list notably included availability of newer treatment

Monkeypox Knowledge and Confidence in Diagnosis and Management with Evaluation of Emerging Virus Infection Conspiracies among Health Professionals in Kuwait

As the 2022 human monkeypox (HMPX) multi-country outbreak is spreading, the response of healthcare workers (HCWs) is central to mitigation efforts. The current study aimed to evaluate HMPX knowledge and confidence in diagnosis and management among HCWs in Kuwait. We used a self-administered questionnaire distributed in July–August 2022 through a snowball sampling approach. The survey items evaluat

Female entrepreneurship, creating shared value, and empowerment in tourism; the neutralizing effect of gender-based discrimination

Given the significance of entrepreneurial women’s contribution to the tourism industry and the fifth UN Sustainable Development Goal (gender equality) this study aims to investigate: first, the interrelationship between women entrepreneurship, creating shared value, and women’s empowerment; and second, the effect of gender-based discriminations on women’s entrepreneurship, creation shared value, a

Early Versus Delayed Non-Vitamin K Antagonist Oral Anticoagulant Therapy after Acute Ischemic Stroke in Atrial Fibrillation (TIMING) : A Registry-Based Randomized Controlled Noninferiority Study

Background: There are no evidence-based recommendations on the optimal time point to initiate non-vitamin K antagonist oral anticoagulants (NOACs) after acute ischemic stroke in patients with atrial fibrillation. We aimed to investigate the efficacy and safety of early versus delayed initiation of NOAC in these patients. Methods: TIMING (Timing of Oral Anticoagulant Therapy in Acute Ischemic Strok

Large eddy simulation of n-dodecane spray flame : Effects of injection pressure on spray combustion characteristics at low ambient temperature

The present study uses large-eddy simulations (LES) to identify the underlying mechanism that governs the ignition and stabilization mechanisms of ECN Spray A flame for different injection pressures (Pinj) and ambient temperatures (Tam). Two Pinj of 50 MPa and 150 MPa, as well as two Tam of 750 K and 900 K are considered. The numerical model is validated against the experimental fuel penetration,

A human monoclonal antibody bivalently binding two different epitopes in streptococcal M protein mediates immune function

Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual who had successfully cleared a group A streptococcal infection. The antibodies bind with high affinity in the central region of the surface-bound M protein. Suc

Personal comorbidities and their subsequent risks for liver, gallbladder and bile duct cancers

Many environmental risk factors for hepatobiliary cancers are known but whether they are associated with specific cancer types is unclear. We present here a novel approach of assessing standardized incidence ratios (SIRs) of previously diagnosed comorbidities for hepatocellular carcinoma (HCC), gallbladder cancer (GBC), cholangiocarcinoma (CCA) and ampullary cancer. The 13 comorbidities included a

Implications of future climate change on crop and irrigation water requirements in a semi-arid river basin using CMIP6 GCMs

Agriculture faces risks due to increasing stress from climate change, particularly in semi-arid regions. Lack of understanding of crop water requirement (CWR) and irrigation water requirement (IWR) in a changing climate may result in crop failure and socioeconomic problems that can become detrimental to agriculture-based economies in emerging nations worldwide. Previous research in CWR and IWR has

Barns bästa som överordnad princip och rättslig praktik : en jämförande undersökning av asylbeslut i norsk och svensk utlänningsförvaltning

En aktuell fråga är vilken betydelse det skulle ha för barns rättigheter om barnkonventionen gjordes till svensk lag. Norge, som inkorporerade barnkonventionen i nationell lagstiftning 2003, lyfts ofta fram som ett föregångsland av frivilligorganisationer, men effekten av en inkorporering har inte undersökts närmare i någon vetenskaplig studie. Föreliggande artikel behandlar principen om barnets b

MicroRNAs in Type 2 Diabetes : Focus on MicroRNA Profiling in Islets of Langerhans

Differential expression of microRNAs (miRNAs) is observed in many diseases including type 2 diabetes (T2D). Insulin secretion from pancreatic beta cells is central for the regulation of blood glucose levels and failure to release enough insulin results in hyperglycemia and T2D. The importance in T2D pathogenesis of single miRNAs in beta cells has been described; however, to get the full picture, h

Unified Theory of Characteristic Modes : Part II - Tracking, Losses, and FEM Evaluation

This is the second component of a two-part paper dealing with a unification of characteristic mode decomposition. This second part addresses modal tracking, interpolation, the role of ohmic losses, and presents several numerical examples for surface-based method-of-moment formulations. A new tracking algorithm based on algebraic properties of the transition matrix is developed, achieving excellent

Monkeypox : A Comprehensive Review

The 2022 multi-country monkeypox outbreak in humans has brought new public health adversity on top of the ongoing coronavirus disease 2019 (COVID-19) pandemic. The disease has spread to 104 countries throughout six continents of the world, with the highest burden in North America and Europe. The etiologic agent, monkeypox virus (MPXV), has been known since 1959 after isolation from infected monkey