Insights into oceanographic environmental conditions such as paleoproductivity, deep-water temperatures, salinity, ice volumes, and nutrient cycling have all been obtained from geochemical analyses of biomineralized carbonate of marine organisms. However, we cannot fully understand geochemical proxy incorporation and the fidelity of such in species until we better understand fundamental aspects of

Biologic and clinical observations suggest that combining imatinib with IFN-alpha may improve treatment outcome in chronic myeloid leukemia (CML). We randomized newly diagnosed chronic-phase CML patients with a low or intermediate Sokal risk score and in imatinib-induced complete hematologic remission either to receive a combination of pegylated IFN-alpha 2b (Peg-IFN-alpha 2b) 50 mu g weekly and i

Objective: To evaluate if the measurement of survivin in the blood of patients with rheumatoid arthritis (RA) undergoing infliximab treatment has predictive value for treatment response. Methods: The study included 87 consecutive RA patients (age 24-89 years, disease duration 18-526 months) treated with regular infusions of influximab. Survivin levels were measured by enzyme-linked immunosorbent a

This study is based on qualitative interviews with 20 adult international adoptees of colour and eight adoptive parents with internationally adopted children in Sweden regarding their experiences of racialization, ethnic identifications and coping strategies. The findings suggest that the non-white bodies of the adoptees are constantly made significant in their everyday lives in interactions with

Synthesis of several enantiomerically pure unsaturated bicyclo[3.3.1]nonane and related brexane (tricyclo[4.3.0.0(3,7) ]nonane) derivatives bearing exocyclic benzylidene substituents from readily available (+)-(1S,5S)-bicyclo[3.3.1]nonane-2,6-dione was accomplished. Molecular geometry and chiroptical properties of compounds with enone and styrene chromophores were studied by X-ray diffraction anal

The IDEM3 maturity model is a process improvement framework that can be used by an organisation to assess and improve their IT dependability management processes. The framework focuses on the coordination of IT management and safety management within an organisation. In this paper, an evaluation plan for the maturity model is presented to evaluate its applicability, assessment accuracy, and practi

Introduction: Twelve-lead electrocardiogram (ECG) is used to screen for hypertrophic cardiomyopathy (HCM), but up to 25% of HCM patients do not have distinctly abnormal ECGs, whereas up to 5% to 15% of healthy athletes do. We hypothesized that an approximately 5-minute resting advanced 12-lead ECG test ("A-ECG score") could detect HCM with greater sensitivity than pooled conventional ECG criteria

Thirteen common susceptibility loci have been reproducibly associated with cutaneous malignant melanoma (CMM). We report the results of an international 2-stage meta-analysis of CMM genome-wide association studies (GWAS). This meta-analysis combines 11 GWAS (5 previously unpublished) and a further three stage 2 data sets, totaling 15,990 CMM cases and 26,409 controls. Five loci not previously asso

The growth and atomic/electronic structure of molecular beam epitaxy-grown ErAs nanoparticles and nanorods embedded within a GaAs matrix are examined for the first time via cross-sectional scanning tunneling microscopy and spectroscopy. Cross sections enable the interrogation of the internal structure and are well suited for studying embedded nanostructures. The early stages of embedded ErAs nanos

Cellulase-producing fungi from the Andean regions in Bolivia, an ecosystem characterized as an extreme arid highland, were studied. Thirty-two isolates were screened for presence of cellulase activity using carboxymethyl cellulose (CMC) as carbon source, and activity was confirmed using a filter paper assay. One isolate, denoted as BLT1C was selected from this screening, and sequence analysis of t

A palynological investigation has been conducted on Lower-Upper Miocene sediments from Jylland, Denmark, corresponding to the time interval of about 19 to 8 Ma. The sediments, derived from the Sdr. Vium drill core, were deposited in marine to marginal-marine environments, as shown by the relatively high abundance of dinoflagellate cysts in all samples. Nevertheless, rich and diverse pollen assembl

Astrocytes appear to be important mediators in the clearance of amyloid beta1-42 (A beta), the key component of senile plaques characteristic of Alzheimer's disease (AD). Recently, we found the amyloid associated proteins (AAPs) alpha 1-antichymotrypsin (ACT), apolipoprotein J and E (ApoJ and ApoE) and a mixture of serum amyloid P (SAP) and C1q (SAP-C1q) to modify A beta-uptake by human astrocytes

This paper explores the institutional and economic development in ancient Athens from around 600 BC into the fourth century, a period during which the Athenians experienced oligarchy, tyranny, a gradually evolving but eventually far-reaching male democracy, followed by a return to more influence for the elite. Concomitantly, economic life changed qualitatively and quantitatively. Self-sufficient f

A pioneer study of the previously unknown delta C-13 chemostratigraphy in the Ordovician/Silurian boundary interval in eastern Iowa and northeastern Illinois resulted in the discovery of the Hirnantian Isotope Carbon Excursion (HICE). The presence of this major isotope excursion in the Mosalem Formation in Iowa and the Wilhelmi Formation in Illinois, which indicates that the excursion interval in

We propose a mechanism of how the desire to maintain friendships can intensify gender differences in educational choice. The required conditions for this mechanism would be that (1) adolescent males and females differ in their overall educational preferences, (2) wanting to stay close to friends motivates some adolescents to adjust their educational choice in line with their friends' choices, and

Complementary experimental techniques and ab initio calculations were used to determine the origin and nature of negative thermal expansion (NTE) in the archetype metal-organic framework MOF-5 (Zn4O(1,4-benzenedicarboxylate) (3)). The organic linker was probed by inelastic neutron scattering under vacuum and at a gas pressure of 175 bar to distinguish between the pressure and temperature responses

The paper compares direct and indirect model reference adaptive controllers (MRAC) with the L-1 adaptive controller. The architectures of the closed-loop systems are first compared in a simple setting that clarifies the similarities and differences of the controllers. The indirect MRAC and the L-1 controller have identical state predictors, but they differ in the computation of the control signal,

Heat stress at the workplace is an occupational health hazard that reduces labour productivity(1). Assessment of productivity loss resulting from climate change has so far been based on physiological models of heat exposure(1). These models suggest productivity may decrease by 11-27% by 2080 in hot regions such as Asia and the Caribbean(2), and globally by up to 20% in hot months by 2050(3). Using

To determine benefits and harms of arthroscopic knee surgery involving partial meniscectomy, debridement, or both for middle aged or older patients with knee pain and degenerative knee disease.