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Restraint effects in portal frame bridges : Practical design methodologies and background information
This report presents methodology, results and conclusions from the PhD-project “Evaluation, modeling and handling of restraint stresses in concrete bridges”, which can be relevant for bridge designers. The project investigated thermal actions in portal frame bridges, and the widths of cracks resulting from restraint effects. The main results and conclusions are given in the summary in Swedish, whi
What is gender, anyway : a review of the options for operationalising gender
In the social sciences, many quantitative research findings as well as presentations of demographics are related to participants’ gender. Most often, gender is represented by a dichotomous variable with the possible responses of woman/man or female/male, although gender is not a binary variable. It is, however, rarely defined what is meant by gender. In this article, we deconstruct the concept ‘ge
Introduction of a method to calculate cumulative age- And gender-specific lifetime attributable risk (LAR) of cancer in populations after a large-scale nuclear power plant accident
The effect of age and gender in risk estimates related to long-term residence in areas contaminated by nuclear power plant fallout was evaluated by applying the lifetime attributable risk (LAR) concept to an existing exposure model that was previously used for cumulative effective dose estimates. In this study, we investigated the influence of age distribution on the number of cancer cases by appl
The brain of a nocturnal migratory insect, the Australian Bogong moth
Every year, millions of Australian Bogong moths (Agrotis infusa) complete an astonishing journey: In Spring, they migrate over 1,000 km from their breeding grounds to the alpine regions of the Snowy Mountains, where they endure the hot summer in the cool climate of alpine caves. In autumn, the moths return to their breeding grounds, where they mate, lay eggs and die. These moths can use visual cue
Monotone Smoothing Splines with Bounds
The problem of monotone smoothing splines with bounds is formulated as a constrained minimization problem of the calculus of variations. Existence and uniqueness of solutions of this problem is proved, as well as the equivalence of it to a finite dimensional but nonlinear optimization problem. A new algorithm for computing the solution which is a spline curve, using a branch and bound technique, i
Gränslösa rörelser för fred 1889–1914 : Aktörskap, strategi och begreppsvärld hos socialistisk och liberal fredsaktivism
Avhandlingen behandlar den socialistiska respektive den liberala internationella fredsrörelse som agerade under kvartsseklet före första världskrigets utbrott 1914.During the 25 years before the First World War in 1914 two different kinds of peace movements, one bourgeois-liberal and one socialist, were organised to fight militarism and war. The two movements – represented by the International Peace Bureau and the Second International, respectively – grew in size between 1889 and 1914. At the beginning of 1914, IPB organized over 200 peace associations, repr
White Matter Brain Development after Exposure to Circulating Cell-Free Hemoglobin and Hyperoxia in a Rat Pup Model
Neonates born with critical congenital heart defects are at risk of diffuse white matter injuries and neurodevelopmental impairments. This study aimed to determine the impact of circulating cell-free hemoglobin and hyperoxia, both present during cardiopulmonary bypass circulation, on white matter brain development. Postnatal day 6 rat pups were injected intraperitoneally with cell-free Hb or vehic
Preparation of human dihydroorotate dehydrogenase for interaction studies with lipid bilayers
Human dihydroorotate dehydrogenase (DHODH) is an integral protein of the inner mitochondrial membrane (IMM) that catalyzes the fourth step of the de novo pyrimidine biosynthesis and is functionally connected to the respiratory chain via its lipophilic co-substrate, ubiquinone Q10. DHODH is the target for drugs approved for the treatment of rheumatoid arthritis and multiple sclerosis, and mutations
Anti-phospholipid antibodies and renal involvement are the main features associated with adverse pregnancy outcomes in patients with Systemic Lupus Erythematosus. A long-term longitudinal study in Southern Sweden
Background Systemic Lupus Erythematosus (SLE) affects mostly women in childbearing age. Modern management of SLE patients has improved the pregnancy outcomes over the last decades. However, there is still an increased risk of maternal, fetal and neonatal complications. In this longitudinal follow-up of pregnant women affected by SLE, we aimed to investigate which clinical and immunological feature
Sharing data-taming the beast : Barriers to meta-analyses of individual patient data (IPD) and solutions
Low bone mineral density is associated with hypogonadism and cranial irradiation in male childhood cancer survivors
Summary: We investigated if bone mineral density was related to testosterone deficiency and/or previous cancer treatment in men who were childhood cancer survivors. Men with untreated testosterone deficiency or previous treatment with cranial irradiation were at increased risk of impaired bone health. Prevention of osteoporosis should be considered in their follow-up. Introduction: Childhood cance
Ultra-High Dose Rate (FLASH) Radiotherapy : Silver Bullet or Fool's Gold?
Radiotherapy is a cornerstone of both curative and palliative cancer care. However, radiotherapy is severely limited by radiation-induced toxicities. If these toxicities could be reduced, a greater dose of radiation could be given therefore facilitating a better tumor response. Initial pre-clinical studies have shown that irradiation at dose rates far exceeding those currently used in clinical con
Adverse pregnancy outcomes (APOs) after mult-professional follow-up ín women affected by Systemic Lupus Erythematosus (SLE). : Report from a single center in Southern Sweden.
Structural Factors Responsible for Universal Health Coverage in Low- and Middle-Income Countries : Results From 118 Countries
Background: Demography, politics, economy, and governance appear to be the major structural factors for health and well-being. These factors have a significant role to play in achieving universal health coverage (UHC). The majority of previous studies did not highlight those factors. The aim of this study is to explore the basic structural factors (political stability, demography, gross national i
Electron-Magnon Coupling and Nonlinear Tunneling Transport in Magnetic Nanoparticles
We present a theory of single-electron tunneling transport through a ferromagnetic nanoparticle in which particle-hole excitations are coupled to spin collective modes. The model employed to describe the interaction between quasiparticles and collective excitations captures the salient features of a recent microscopic study. Our analysis of nonlinear quantum transport in the regime of weak couplin
Theory of Tunneling Spectroscopy in a Mn12 Single-Electron Transistor by Density-Functional Theory Methods
We consider tunneling transport through a Mn12 molecular magnet using spin density functional theory. A tractable methodology for constructing many-body wave functions from Kohn-Sham orbitals allows for the determination of spin-dependent matrix elements for use in transport calculations. The tunneling conductance at finite bias is characterized by peaks representing transitions between spin multi
Localization of the gene for congenital dyserythropoietic anemia type III, CDAN3, to chromosome 15q21-q25
Congential dyserythropoietic anemia, type III (CDA III) is a rare autosomal dominant disorder characterized by macrocytic anemia, bone marrow erythroid hyperplasia and giant multlnucleate erythroblasts. We have genetically characterized a large Swedish family in which the concurrence of CDA III and myeloma or benign monoclonal gammopathy is significantly higher than expected and have found that th
Meta-analysis of four Swedish case-control studies on exposure to pesticides as risk-factor for soft-tissue sarcoma including the relation to tumour localization and histopathological type
In four previous case-control studies we have shown an association between exposure to phenoxyacetic acids or chlorophenols and soft-tissue sarcoma (STS). These chemicals are contaminated by dioxins and dibenzofurans, some of which are known carcinogens in experimental animals. In a meta-analysis of our four studies we studied such exposure including the relation to tumour localization and histopa
Adipose tissue concentrations of dioxins and dibenzofurans in patients with malignant lymphoproliferative diseases and in patients without a malignant disease
Concentrations of dioxins (PCDD) and dibenzofurans (PCDF) were analysed in adipose tissue from seven patients with malignant lymphoproliferative diseases and 12 surgical patients without a malignant disease. All cases in the first group had reported potential exposure to PCDD and PCDF. Of the analysed congeners significantly higher concentrations of 1, 2, 3, 7, 8-pentachlorodioxin, 1, 2, 3, 6, 7,