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Risk-reducing salpingo-oophorectomy, natural menopause, and breast cancer risk: an international prospective cohort of BRCA1 and BRCA2 mutation carriers

BACKGROUND: The effect of risk-reducing salpingo-oophorectomy (RRSO) on breast cancer risk for BRCA1 and BRCA2 mutation carriers is uncertain. Retrospective analyses have suggested a protective effect but may be substantially biased. Prospective studies have had limited power, particularly for BRCA2 mutation carriers. Further, previous studies have not considered the effect of RRSO in the context

Shifting Gears : Automated Driving on the Eve of Autonomous Drive

The compelling images and promises attached to autonomous drive vehicles can easily create an impression that one can speak of a radical distinction between a self-driving future and a manual-driving present. Yet today’s drivers can already refer to their everyday driving as being experienced as though on ‘auto-pilot’, in which they are able to drive their cars while lost in things such as daydrea

Exceptions, limitations and collective management of rights as vehicles for access to information

Copyright law reflects a balance between the competing interests of protection and access. It is often held that this balance has been disturbed by recent technological and related legal developments. This article describes and compares two vehicles to enhance access to information in the online environment, while also taking into account the interest of protection: (i) the introduction of (broade

Cross-Border Extended Collective Licensing : A Solution to Online Dissemination of Europe’s Cultural Heritage

The ever increasing use of the Internet and of digitisation technologies have opened up new possibilities for distributing and accessing creative content online, including for cultural heritage institutions. However, the digitisation and dissemination of a substantial proportion of the collections held by European cultural institutions may be considerably hindered due to high transaction costs rel

Joint species distribution modelling with the r-package Hmsc

Joint Species Distribution Modelling (JSDM) is becoming an increasingly popular statistical method for analysing data in community ecology. Hierarchical Modelling of Species Communities (HMSC) is a general and flexible framework for fitting JSDMs. HMSC allows the integration of community ecology data with data on environmental covariates, species traits, phylogenetic relationships and the spatio-t