Botulinum neurotoxins (BoNTs) and tetanus neurotoxin (TeNT) are the most potent toxins known and cause botulism and tetanus, respectively. BoNTs are also widely utilized as therapeutic toxins. They contain three functional domains responsible for receptor-binding, membrane translocation, and proteolytic cleavage of host proteins required for synaptic vesicle exocytosis. These toxins also have dist

The potentially tridentate ligand bis[(1-methyl-2-benzimidazolyl)ethyl]amine (2BB) was employed to prepare copper complexes [(2BB)CuI]OTf and [(2BB)CuII(H2O)2](OTf)2 as bioinspired models of lytic polysaccharide copper-dependent monooxygenase (LPMO) enzymes. Solid-state characterization of [(2BB)CuI]OTf revealed a Cu(I) center with a T-shaped coordination environment and metric parameters in the r

In phase-change memory devices, a material is cycled between glassy and crystalline states. The highly temperature-dependent kinetics of its crystallization process enables application in memory technology, but the transition has not been resolved on an atomic scale. Using femtosecond x-ray diffraction and ab initio computer simulations, we determined the time-dependent pair-correlation function o

The transition to a circular economy requires the development of new business models. However, ‘circular’ businesses face a number of barriers when competing in the current ‘linear’ economy, and may require the support of public policies. Public procurement may be applied for this purpose, as it can support emerging markets for reconditioned and remanufactured products. Public procurement can also

Linear or cyclic carbonates as potential monomers for isocyanate-free polyurethanes and polycarbonates were prepared from polyols and dialkylcarbonatesor diphenyl carbonates. This invention was developed to produce linear or cyclic carbonates with or without using catalysts. Polyol compounds were reacted with carbonates such as dimethylcarbonate and diethylcarbonate to produce thecorresponding lin

Under de senaste tre åren har Malmö haft 26 dödsskjutningar. Men efter att polisen börjat sätta hårt mot hårt med ett effektivt spanings­arbete, punktmarkering av tongivande kriminella, samverkan med andra myndigheter och en satsning på avhopparverksamheten har våldet med skjutvapen minskat betydligt, skriver kriminolog Ardavan Khoshnood.Over the past three years, Malmö has witnessed 26 homicides by firearm. Only after that the police responded with vigorous countermeasures like a more effective surveillance, marking high offending and leading criminals, collaboration with other authorities and a massive investment in the defector's program. Ardavan Khoshnood, Criminologist, writes that these measurements have contributed to a sig

This article addresses the dilemmas concerning legislation, individual autonomy and the reality of everyday life for people coping with dementia. We describe and analyse decision-making in relation to older people with dementia in Sweden, within the area of social work regulated by the Social Services Act and the Parental Act. Swedish legislation is based on the individual’s autonomy and capacity

Purpose. This study aimed to investigate the effects of using hand grip or resisted wrist extension as the reference contraction, and two electrode positions, on field recordings of forearm extensor muscle activity. Materials and methods. Right forearm extensor muscle activity was recorded using two electrode pairs (over the most prominent part (position 2) and proximal to that (position 1)) durin

Aim: To increase understanding of the consequences of growing up with substance-abusing parents, including how this can influence the experience of becoming a parent. Methods: In-depth interviews were conducted with 19 parents who had participated in an Infant and Toddler Psychiatry Unit intervention programme and who had experienced substance-abusing parents in their family of origin. Directed qu

Wood is a hygroscopic material that absorbs and desorbs water to equilibrate to the ambient climate. Within material science, the moisture range from 0 to about 95-98% relative humidity is generally called the hygroscopic moisture range, while the exceeding moisture range is called the over-hygroscopic moisture range. For wood, the dominating mechanisms of moisture sorption are different in these

Floods are natural hazards with serious impact on many aspects of human life. The Intergovernmental Panel on Climate Change (IPCC) reported that climate change already has significant impact on magnitude and frequency of flood events worldwide. Thus, it is suggested to adopt strategies to manage damage impacts of climate change. For this, involving the local community in the decision-making proces

In this study, we investigate how prosodic cues are used when an overt pronoun is associated with either a subject or an object antecedent in Italian and in Swedish. To address this question, 28 Italian speakers and 28 Swedish speakers completed a production task, by reading out loud globally-ambiguous sentences containing overt pronouns and a control interpretation task, where they selected eithe

Précis: A correct diagnosis of glaucoma established at initial visits. Purpose: It has been suggested that a diagnosis of glaucoma cannot be certain until progression has been demonstrated. Our aim was to evaluate the correctness of a glaucoma diagnosis established after 2 initial visits. Patients and Methods: Patients included in the Early Manifest Glaucoma Trial (EMGT) who had continued follow-u

Chronic obstructive pulmonary disease (COPD) affects the lives of an ever-growing number of people worldwide. The lack of understanding surrounding the pathophysiology of the disease and its progression has led to COPD becoming the third leading cause of death worldwide. COPD is incurable, with current treatments only addressing associated symptoms and sometimes slowing its progression, thus highl

This experiment was designed to investigate how children cope with salient online advertising while engaging in task-oriented website interaction. 57 children in 3rd grade (9-year-olds) participated in the experiment. Each participant was introduced to a mock-up website and was instructed to solve two types of online tasks: reading for comprehension and information search. The web pages used by th