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A difference scheme for a triangular system of conservation laws with discontinuous flux modeling three-phase flows

A triangular system of conservation laws with discontinuous flux that models the one-dimensional flow of two disperse phases through a continuous one is formulated. The triangularity arises from the distinction between a primary and a secondary disperse phase, where the movement of the primary disperse phase does not depend on the local volume fraction of the secondary one. A particular applicatio

The injury-induced transcription factor SOX9 alters the expression of LBR, HMGA2, and HIPK3 in the human kidney

Induction of SRY box transcription factor 9 (SOX9) has been shown to occur in response to kidney injury in rodents, where SOX9-positive cells proliferate and regenerate the proximal tubules of injured kidneys. Additionally, SOX9-positive cells demonstrate a capacity to differentiate toward other nephron segments. Here, we characterized the role of SOX9 in normal and injured human kidneys. SOX9 exp

Recent advances in luminescence dating of the Late Quaternary sediments in the Baltic States, Northern Europe : A review

Late Quaternary glaciations, deglaciations, sea-level changes and aeolian activity have resulted in an abundance of clastic sediments that currently cover the three Baltic States, Northern Europe almost entirely. The chronology for these deposits has largely been established from luminescence dating. This review synthesises 201 luminescence ages obtained between 2011 and 2021 on sediments in the B

Natural flavonoids exhibit potent anticancer activity by targeting microRNAs in cancer : A signature step hinting towards clinical perfection

Cancer prevalence and its rate of incidence are constantly rising since the past few decades. Owing to the toxicity of present-day antineoplastic drugs, it is imperative to explore safer and more effective molecules to combat and/or prevent this dreaded disease. Flavonoids, a class of polyphenols, have exhibited multifaceted implications against several diseases including cancer, without showing s

Nanoscale characterization of collagen structural responses to in situ loading in rat Achilles tendons

The specific viscoelastic mechanical properties of Achilles tendons are highly dependent on the structural characteristics of collagen at and between all hierarchical levels. Research has been conducted on the deformation mechanisms of positional tendons and single fibrils, but knowledge about the coupling between the whole tendon and nanoscale deformation mechanisms of more commonly injured energ

Effect of psychotropics on the risk of COVID-19 in middle-aged and older adults

Older adults have been markedly impacted by the coronavirus disease 19 (COVID-19) pandemic, and many reports have cited concerns regarding potential psychiatric sequelae of coronavirus disease (COVID-19), but the actual effects of psychotropics on the COVID-19 are unclear. In this study, multivariate logistic regression was used to evaluate associations between the prescription of psychotropics an

The advantages of standardizing exhaled breath-alcohol concentration to a reference respiratory gas—water vapor

Measuring the concentration of alcohol (ethanol) in exhaled breath (BrAC) provides a rapid and non-invasive way to determine the co-existing concentration in arterial blood (A-BAC). The results of breath-alcohol testing are used worldwide as evidence of excessive drinking, such as when traffic offenders are prosecuted. Two types of breath-alcohol analyzer are in common use; hand-held instruments u

ZEAL : protein structure alignment based on shape similarity

Motivation: Most protein-structure superimposition tools consider only Cartesian coordinates. Yet, much of biology happens on the surface of proteins, which is why proteins with shared ancestry and similar function often have comparable surface shapes. Superposition of proteins based on surface shape can enable comparison of highly divergent proteins, identify convergent evolution and enable detai

TWO THEOLOGIANS AND “WHY I AM NOT A CHRISTIAN”

Bertrand Russell’s speech “Why I Am Not a Christian” (1927) triggered many theologians to defend Christian beliefs. Aside from his rational criticism of the so-called “proofs” of God’s existence, it is his humorous irony as a rhetorical weapon that made many abandon their faith in Christianity and become atheists or at least agnostics. In this article I examine two British theologians’ unsuccessfu

Internment of Enemy Aliens during the World Wars

The article offers a historical approach to one of the most understudied areas of international humanitarian law by focusing on the successes and shortfalls of the two international armed conflicts with the highest numbers of civilians interned in global history. Through the study of State practice during Word War I and Word War II, the author addresses the causes and justifications that led to ma

Excisional Procedures : Liposuction

Lymphedema negatively impacts patients’ quality of life, both physiologically and psychologically. Lymph stasis and inflammation result in excess formation of adipose tissue, which makes removal of the deposited subcutaneous fat necessary to eliminate the excess volume. Liposuction, combined with postoperative controlled compression therapy, is the only treatment that gives complete reduction of t

Bioengineering Approaches for the Distal Lung

Chronic and acute lung diseases are the third and fourth leading causes of global mortality. Distal lung tissue is severely damaged in many lung diseases, causing respiratory insufficiency from loss of surface area available for gas exchange. Current therapies aim at relieving symptoms and are unable to reverse disease. Lung transplantation remains the only potential curative option at end-stage d

Quantitative In Vivo Imaging of the Androgen Receptor Axis Reveals Degree of Prostate Cancer Radiotherapy Response

Non-invasive biomarkers for androgen receptor (AR) pathway activation are urgently needed to better monitor patient response to prostate cancer (PCa) therapies. AR is a critical driver and mediator of resistance of PCa but currently available non-invasive PCa biomarkers to monitor AR activity are discordant with downstream AR pathway activity. External beam radiotherapy (EBRT) remains a common tre

The importance of resource interaction in strategies for managing supply chain disruptions

The turbulent business environment highlights the need for strategies for mitigating, responding to, and recovering from (that is, managing) supply chain disruptions. Resources are central in these strategies but remain unspecified in the literature. This paper shows how the resource interaction approach (RIA) can help understanding resources in this setting by acknowledging their interactive and