We have recently shown that the human Nuclear pore-associated protein (NPAP1)/C15orf2 gene encodes a nuclear pore-associated protein. This gene is one of several paternally expressed imprinted genes in the genomic region 15q11q13. Because the Prader–Willi syndrome is known to be caused by the loss of function of paternally expressed genes in 15q11q13, a phenotypic contribution of NPAP1 cannot be e

The ectodermal neural cortex (ENC) gene family, whose members are implicated in neurogenesis, is part of the kelch repeat superfamily. To date, ENC genes have been identified only in osteichthyans, although other kelch repeat-containing genes are prevalent throughout bilaterians. The lack of elaborate molecular phylogenetic analysis with exhaustive taxon sampling has obscured the possible link of

Growing globalisation and climate change are challenging the sustainability of our societies. It is now clear that climate change and its devastating impacts cannot be resolved by new technology or governance alone. They require a broader, cultural shift. As a result, the role of human beings' ‘inner dimensions’ and related transformations is attracting increased attention from researchers. Recent

In the present study, one type of uniformly nanostructured surface (NPDS) was modified by electrophoretic deposition. Two kinds of micro/nanostructured surfaces (FLS1 and FLS2) were fabricated on copper surfaces by femtosecond laser processing. The micro/nanostructured surfaces were further modified by electrophoretic deposition. Afterwards, composite micro/nanostructured surfaces (CS1 and CS2) we

This study analysed demand for 12 metals in global climate mitigation scenarios up to 2060 and quantified the impacts on demand of different assumptions on improvements and technological mix. Annual and cumulative demands were compared with reserves and current mining rates. The study results showed that reserves are sufficient to support the total level of solar power, wind power and electric mot

Ribs are widely employed in internal cooling passages of turbine blades and other heat transfer equipment to enhance heat transfer by making cooling air flow through internal ribbed passages. From mathematics, a fractal is an abstract object used to simulate naturally occurring objects, which exhibits similar patterns and properties also at smaller scales. The evolving fractal structures of the co

Background: Anteroseptal ST elevation myocardial infarction (STEMI) is traditionally defined on the electrocardiogram (ECG) by ST elevation (STE) in leads V1-V3, with or without involvement of lead V4. It is commonly taught that such infarcts affect the basal anteroseptal myocardial segment. While there are suggestions in the literature that Q waves limited to V1-V4 represent predominantly apical

Objectives: As the various regional authorities responsible for health care in Sweden operate independently, no knowledge was available on pre-school hearing screening available to children living in different parts of the country. The aim of this study was to carry out a survey to ascertain how preschool hearing screening was performed in the various regions of Sweden. An objective of the present

CONTEXT: Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.OBJECTIVE: To determine whether there is a relationship between microstructural white matter (WM) alterations detected with diffusion tensor imaging (DTI) and cognition in adults with childhood-onset CP.DESIGN: A cross-sectional study with a median foll

Aims: Mechanoafferent and peristaltic mechanisms of the human ureter involve transient receptor potential V1 (TRPV1)- and purinoceptor-mediated functions. Hydrogen sulphide, an endogenous TRPA1 ligand, is linked to inhibitory neurotransmission of the pig ureter. No information is available on TRPA1 activity in the human ureter. We therefore examined the distribution and function of TRPA1 in the hu

We analyse the effect of business model innovation (BMI) on the product innovation performance of firms, based on a dynamic capabilities theoretical framework. Our empirical study is based on a large-scale representative sample of cross-industry Swedish firms participating in three waves of the Community Innovation Survey (CIS) from 2008 to 2012. We hypothesise that BMI in the form of product inno

En handskrift som en gång tillhörde Alvastra kloster, nu Uppsala Universitetsbibliotek C 37, innehåller en delvis kalendariskt ordnad predikosamling nedskriven i början av 1200-talet, utan kända paralleller. Artikeln beskriver samlingen och konstaterar att innehållet har både monastisk och folklig prägel. En möjlig slutsats är att en munk i Alvastra har sammanställt/författat predikningarna för at

The development of MIMO over-the-air (OTA) test methodology is an ongoing activity in 3GPP RAN4, CTIA and EU COST Action 2100. In this paper, the focus is on the anechoic chamber approach, which uses a uniform circular array of probe antennas to replicate directional channels for the device-under- test at the array center. In particular, we study in simulation the complexity requirements of implem

History and archaeology have a well-established engagement with issues of premodern societal development and the interaction between physical and cultural environments; together, they offer a holistic view that can generate insights into the nature of cultural resilience and adaptation, as well as responses to catastrophe. Grasping the challenges that climate change presents and evolving appropria

Traditionally, doctoral education is designed to train students to become skilled researchers in their respective disciplines. In many cases, however, doctoral graduates find themselves ill-prepared for their career choices. In this paper, we adopt a systematic approach to study the career preparation aspect of doctoral study in our home department. Our findings reveal several shortcomings in the

Objectives/Hypothesis: TNM-classification inadequately estimates patient-specific overall survival (OS). We aimed to improve this by developing a risk-prediction model for patients with advanced larynx cancer. Study Design: Cohort study. Methods: We developed a risk prediction model to estimate the 5-year OS rate based on a cohort of 3,442 patients with T3T4N0N+M0 larynx cancer. The model was inte

The incidence of pancreatic cancer is leveling between sexes. Smoking, high age and heredity are established risk factors, but evidence regarding the influence of hormonal factors is unclear. In this study, we investigated the associations of reproductive factors, use of oral contraceptives (OC) and hormone replacement therapy (HRT) with pancreatic cancer risk in the Malmö Diet and Cancer Study, a