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Revisiting the Origin of the Vertebrate Hox14 by Including Its Relict Sarcopterygian Members

Bilaterian Hox genes play pivotal roles in the specification of positional identities along the anteroposterior axis. Particularly in vertebrates, their regulation is tightly coordinated by tandem arrays of genes [paralogy groups (PGs)] in four gene clusters (HoxA-D). Traditionally, the uninterrupted Hox cluster (Hox1-14) of the invertebrate chordate amphioxus was regarded as an archetype of theve

The African coelacanth genome provides insights into tetrapod evolution

The discovery of a living coelacanth specimen in 1938 was remarkable, as this lineage of lobe-finned fish was thought to have become extinct 70 million years ago. The modern coelacanth looks remarkably similar to many of its ancient relatives, and its evolutionary proximity to our own fish ancestors provides a glimpse of the fish that first walked on land. Here we report the genome sequence of the

Numerical modeling of the coupled feedback between pool fires and their environment

Computational fluid dynamics (CFD) is often used within performance based fire safety engineering and its use has increased as available computational power has increased. However, there is still a need to improve CFD modeling to push it beyond its current usage limitations. Of course such steps must be accompanied by quality assurance by means of validation and verification. In this thesis three

Responses of microbial tolerance to heavy metals along a century-old metal ore pollution gradient in a subarctic birch forest

Heavy metals are some of the most persistent and potent anthropogenic environmental contaminants. Although heavy metals may compromise microbial communities and soil fertility, it is challenging to causally link microbial responses to heavy metals due to various confounding factors, including correlated soil physicochemistry or nutrient availability. A solution is to investigate whether tolerance

Lidar mapping of atmospheric atomic mercury in the Wanshan area, China

A novel mobile laser radar system was used for mapping gaseous atomic mercury (Hg0) atmospheric pollution in the Wanshan district, south of Tongren City, Guizhou Province, China. This area is heavily impacted by legacy mercury from now abandoned mining activities. Differential absorption lidar measurements were supplemented by localized point monitoring using a Lumex RA-915M Zeeman modulation merc

Organic management and cover crop species steer soil microbial community structure and functionality along with soil organic matter properties

It is well recognized that organic soil management stimulates bacterial biomass and activity and that including cover crops in the rotation increases soil organic matter (SOM). Yet, to date the relative impact of different cover crop species and organic vs. non-organic soil management on soil bacteria and fungi and on SOM quantity and quality remains to be tested. We used a long-term (10 years) fu

Thrombospondin-4 mediates cardiovascular remodelling in angiotensin II-induced hypertension

Thrombospondin 4 (TSP-4) expression is induced in the heart and vasculature under pathological conditions, including myocardial infarction, myocardial pressure overload, and hypertension. TSP-4 is linked to remodelling processes, where it may affect extracellular matrix protein organization. In previous work, we studied the role of TSP-4 in small arteries during hypertension using Ang II-treated T

Anti-müllerian hormone levels are associated with live birth rates in ART, but the predictive ability of anti-müllerian hormone is modest

Objectives: The aim was to evaluate the association between serum Anti-Müllerian Hormone (AMH) level and cumulative live birth rates (LBR) in patients undergoing their first in vitro fertilization (IVF) treatment cycle, and to compare serum AMH levels with Antral Follicle Count (AFC) and Ovarian Sensitivity Index (OSI) as predictors of live birth. Study design: A prospective cohort study of 454 pa

Low levels of immunoglobulins and mannose-binding lectin are not associated with etiology, severity, or outcome in community-acquired pneumonia

Background. Disease severity and outcome in community-acquired pneumonia (CAP) depend on the host and on the challenge of the causal microorganism(s). We measured levels of immunoglobulins (Igs) and complement in 257 hospitalized adults with CAP and examined the association of low levels of Igs or complement to microbial etiology, disease severity, and short-term and long-term outcome. Methods. Se

Relationships between multiple biodiversity components and ecosystem services along a landscape complexity gradient

The assessment of effects of anthropogenic disturbance on biodiversity (BD) and ecosystem services (ES) and their relationships are key priorities of the Intergovernmental Panel for Biodiversity and Ecosystem Services. Agricultural landscapes and their associated BD provide multiple ES and it is crucial to understand how relationships between ES and BD components change along gradients of landscap

Temperature effects explain continental scale distribution of cyanobacterial toxins

Insight into how environmental change determines the production and distribution of cyanobacterial toxins is necessary for risk assessment. Management guidelines currently focus on hepatotoxins (microcystins). Increasing attention is given to other classes, such as neurotoxins (e.g., anatoxin-a) and cytotoxins (e.g., cylindrospermopsin) due to their potency. Most studies examine the relationship b

Experimental evaluation of MIMO terminal antenna configurations in noise- and interference-limited urban scenarios

In this paper, we compare capacity performances of three terminal dual-antenna configurations at 2.65 GHz based on extensive 2 by 2 multiple-input multiple-output (MIMO) channel measurements in an urban macrocellular environment. Both noise- and interference-limited scenarios are investigated. Our results show that, on average over the measurement route, the capacity performance is mainly determin

Angle and polarization diversity in compact dual-antenna terminals with chassis excitation

For multiple antennas on a compact terminal chassis, chassis current excitation can severely increase mutual coupling between the antennas. This is because the same characteristic mode of the chassis may be strongly excited by more than one antenna. Here, we propose to use one antenna that exploits chassis excitation and introduce a second antenna that minimizes chassis excitation. In this way, an

Performance of cooperative MIMO based on measured urban channel data

We study the potential benefits of cooperative multiple-input multiple-output signaling from multiple coherent base stations with one or more mobile stations in an urban macrocellular environment. The analysis uses novel and fully coherent measurements of the channel from three base stations to a single mobile station equipped with four antennas. The observed channels are used to explore the gains

Optimal multiple antenna design for compact MIMO terminals with ground plane excitation

The compactness of mobile terminals complicates the design of multiple antennas, since coupling among the antennas increases when they are placed in proximity of one another. While it is possible to mitigate coupling between closely spaced antennas, a tradeoff in bandwidth is required. In this paper, we highlight ground plane excitation as an additional dimension to consider in the design of multi

Small spatial variability in methane emission measured from a wet patterned boreal bog

We measured methane fluxes of a patterned bog situated in Siikaneva in southern Finland from six different plant community types in three growing seasons (2012-2014) using the static chamber method with chamber exposure of 35 min. A mixed-effects model was applied to quantify the effect of the controlling factors on the methane flux.The plant community types differed from each other in their water