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Population-based estimates of common comorbidities and cardiovascular disease in ankylosing spondylitis.
OBJECTIVE:: To study the rate of common comorbidities and cardiovascular disease in ankylosing spondylitis (AS) patients compared with the general population seeking health care. METHODS:: This cohort study included 935 subjects (67% men) age ≥20 years, diagnosed with AS and the adult background population in southern Sweden. During 2004 to 2007 we recorded the occurrence of physicians' diagnostic
Catalytic Activity of the Rh Surface Oxide: CO Oxidation over Rh(111) under Realistic Conditions
Using a combination of surface X-ray diffraction and mass spectrometry at realistic pressures, the CO oxidation reactivity of a Rh(111) model catalyst has been studied in conjunction with the surface structure. The measurements show that it specific thin surface oxide is always present in the high activity regime of Rh-based CO oxidation.
Bicameralism, intra-party bargaining, and the formation of party policy positions : Evidence from the German federal system
How do political parties arrive at their policy positions? We conceptualize position formation in federalist countries as an intra-party bargaining process in which subnational parties compete with each other in an attempt to get their own positions into their national party manifesto. Drawing on theories about inter-party bargaining over ministerial portfolios, we hypothesize that the bargaining
The Relation of Hypnotizability and Dissociation to Everyday Mentation: An Experience-Sampling Study
Research has found that individuals varying in hypnotizability and dissociation respond differently to questionnaires and procedures geared to affect their state of consciousness, but their stream of consciousness in everyday life has not been investigated. We evaluated the everyday mentation of students (N 46) in a 2 (High vs. Low Hypnotizability) 2 (High vs. Low Dissociative) design through expe
Genetic and functional analyses demonstrate a role for abnormal glycinergic signaling in autism
Autism spectrum disorder (ASD) is a common neurodevelopmental condition characterized by marked genetic heterogeneity. Recent studies of rare structural and sequence variants have identified hundreds of loci involved in ASD, but our knowledge of the overall genetic architecture and the underlying pathophysiological mechanisms remains incomplete. Glycine receptors (GlyRs) are ligand-gated chloride
Foreword
Investigating the synergistic efficacy of BMP-7 and zoledronate on bone allografts using an open rat osteotomy model.
Bone grafts are well-established in the treatment of fracture non-unions but union is still not always achieved. Harvesting autograft is associated with donor site morbidity and the available amount of bone is limited. Allograft is more easily obtained and available in greater quantities but lacks the osteoinductive characteristics of autograft. We have previously shown a synergistic effect of bon
EuroSCORE II dagger
To update the European System for Cardiac Operative Risk Evaluation (EuroSCORE) risk model. A dedicated website collected prospective risk and outcome data on 22 381 consecutive patients undergoing major cardiac surgery in 154 hospitals in 43 countries over a 12-week period (May-July 2010). Completeness and accuracy were validated during data collection using mandatory field entry, error and range
Differential Effects of Efavirenz, Lopinavir/r, and Atazanavir/r on the Initial Viral Decay Rate in Treatment Naive HIV-1-Infected Patients
Initial viral decay rate may be useful when comparing the relative potency of antiretroviral regimens. Two hundred twenty-seven ART-naive patients were randomized to receive efavirenz (EFV) (n=74), lopinavir/ritonavir (LPV/r) (n=77), or atazanavir/ritonavir (ATV/r) (n=79) in combination with two NRTIs. The most frequently used NRTI combinations in the EFV and ATV/r groups were the nonthymidine ana
Heart rate is associated with progression of atrial fibrillation, independent of rhythm
Objective Atrial fibrillation (AF) often progresses from paroxysmal or persistent to more sustained forms, but the rate and predictors of AF progression in clinical practice are not well described. Methods Using the Outcomes Registry for Better Informed Treatment of AF, we analysed the incidence and predictors of progression and tested the discrimination and calibration of the HATCH (hypertension,
Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys.
Early-life inorganic arsenic exposure influences not only child health and development but also health in later life. The adverse effects of arsenic may be mediated by epigenetic mechanisms, as there are indications that arsenic causes altered DNA methylation of cancer-related genes. The objective was to assess effects of arsenic on genome-wide DNA methylation in newborns. We studied 127 mothers a
The role of small airway disease in asthma.
This review provides an update on the importance of the peripheral 'small' airways in asthma. As the small airways account for less than 10% of total airway resistance, thus having little impact on standard lung function measures such as forced expiratory volume and peak flow, they have been referred to as the 'silent zone'.
Semicarbazide-functionalized resin as a new scavenger for in situ recovery of 3-hydroxypropionaldehyde during biotransformation of glycerol by Lactobacillus reuteri
3-Hydroxypropionaldehyde (3HPA), a potential C3-platform chemical for a biobased industry, is produced from glycerol using Lactobacillus reuteri through its glycerol dehydratase activity. However, the process is characterized by low yield and productivity due to toxic effects of 3HPA on the biocatalyst activity. In this study, a semicarbazide-functionalized resin was prepared, evaluated for adsorp
Prophylactic antibiotics are associated with a lower incidence of pneumonia in cardiac arrest survivors treated with targeted temperature management.
Prophylactic antibiotics (PRO) reduce the incidence of early-onset pneumonia in comatose patients with structural brain injury, but have not been examined in cardiac arrest survivors undergoing targeted temperature management (TTM). We investigated the effect of PRO on the development of pneumonia in that population.
Swedish and English word ratings of imageability, familiarity and age of acquisition are highly correlated
At present, there is no comprehensive psycholinguistic database containing Swedish words with ratings of word properties such as e.g. imageability, although researchers carrying out psycholinguistic studies in Swedish face the need to be able to control for and systematically vary such properties. The present study addressed this issue by investigating the possibility of transferring English word
Global terrestrial isoprene emission models: sensitivity to variability in climate and vegetation
Due to its effects on the atmospheric lifetime of methane, the burdens of tropospheric ozone and growth of secondary organic aerosol, isoprene is central among the biogenic compounds that need to be taken into account for assessment of anthropogenic air pollution-climate change interactions. Lack of process-understanding regarding leaf isoprene production as well as of suitable observations to con
Self-catalyzed MBE grown GaAs/GaAsxSb1-x core-shell nanowires in ZB and WZ crystal structures
We have investigated the growth of self-catalyzed GaAs/GaAsxSb1-x core-shell nanowires directly on Si(111) substrates by molecular beam epitaxy. The compositions of the GaAsxSb1-x shells are tuned in a wide range where the Sb-content is varied from 10 to similar to 70%, covering the miscibility gap. In addition, the GaAsxSb1-x shells are grown on both zinc blende (ZB) and wurtzite (WZ) crystal str
Reflex syncope, anxiety level, and family history of cardiovascular disease in young women: case-control study.
Anxiety is an emotion, which stimulates sympathetic nervous outflow potentially facilitating vasovagal reflex syncope (VVS) but reports on anxiety levels in patients with VVS are sparse.
Restoration of locomotive function in Parkinson's disease by spinal cord stimulation: mechanistic approach
Specific motor symptoms of Parkinson's disease (PD) can be treated effectively with direct electrical stimulation of deep nuclei in the brain. However, this is an invasive procedure, and the fraction of eligible patients is rather low according to currently used criteria. Spinal cord stimulation (SCS), a minimally invasive method, has more recently been proposed as a therapeutic approach to allevi