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Introduction: Elevated red cell distribution width (RDW) has been associated with a range of health outcomes. This study aims to examine prognostic and etiological roles of RDW levels, both phenotypic and genetic predisposition, in predicting cardiovascular outcomes, diabetes, chronic kidney disease (CKD) and mortality. Methods: We studied 27,141 middle-aged adults from the Malmö Diet and Cancer s

In 2019 and 2021, the European League for Rheumatism (EULAR) jointly with the European Renal Association (ERA) and the Kidney Disease: Improving Global Outcomes (KDIGO), respectively, released updated guidelines on the management of lupus nephritis (LN). The Immunology Working Group of the ERA reviewed and compared both updates. Recommendations were either consistent or differences were of negligi

Carbon emissions from buildings have inherently dynamic characteristics since buildings evolve over time. Most previous studies, however, implemented static building carbon regimes, ignoring the temporal variation of many factors that govern carbon emissions of buildings. This research explores the influences of four dynamic factors acting on building carbon emissions: dynamic climate change data,

Business school faculty are frequently faced with management practices they find objectionable. Reactions vary, but compliance and hidden resistance are common responses. In this paper, we seek to understand compliance and hidden resistance as responses to objectionable management practices in business schools. To explore this problem, we present a case study of a business school where a new dean

Polycrystalline cubic boron nitrides (PcBN) have been increasingly used together with PVD coatings, mainly for hard turning operations. Within this context, effectiveness of coated PcBN as cutting tool is usually addressed by evaluation of its machining performance. Meanwhile, studies aiming to assess and understand the correlation between microstructural features and mechanical behaviour of the c

This paper explores the evolution of research methodology in the study of student notetaking in higher education (HE) and its impact on pedagogic approaches. While acknowledging the importance of notetaking for student learning, the paper argues that the overreliance of randomized control trials (RCTs) has led to some potentially misleading conclusions about lectures in HE and the notes students m

Aims CD40 and its ligand, CD40L, play a critical role in driving atherosclerotic plaque development. Disrupted CD40-signalling reduces experimental atherosclerosis and induces a favourable stable plaque phenotype. We recently showed that small molecule-based inhibition of CD40-tumour necrosis factor receptor associated factor-6 interactions attenuates atherosclerosis in hyperlipidaemic mice via ma

Background: Most patients diagnosed with breast cancer present with a node-negative disease. Sentinel lymph node biopsy (SLNB) is routinely used for axillary staging, leaving patients with healthy axillary lymph nodes without therapeutic effects but at risk of morbidities from the intervention. Numerous studies have developed nodal status prediction models for noninvasive axillary staging using po

PIWI-interacting RNAs (piRNAs) are important for ensuring the integrity of the germline. 3'-terminal 2'-O-methylation is essential for piRNA maturation and to protect them from degradation. HENMT1 (HEN Methyltransferase 1) carries out the 2'-O-methylation, which is of key importance for piRNA stability and functionality. However, neither the structure nor the catalytic mechanism of mammalian HENMT

Background: A new Chronic Kidney Disease Epidemiology Collaboration equation without the race variable has been recently proposed (CKD-EPIAS). This equation has neither been validated outside USA nor compared with the new European Kidney Function Consortium (EKFC) and Lund-Malmö Revised (LMREV) equations, developed in European cohorts. Methods: Standardized creatinine and measured glomerular filtr

In Sweden, the governance of healthcare is decentralized, so PC is provided with regional or local differences in organization, level of competence, and recourses. Ongoing regional and national initiative to increase quality of pediatric palliative care in Sweden aligns with the international standard of pediatric palliative care as a care directed towards all children with life-threatening or lif

Purpose: Previously reported associations of protein-rich foods with stroke subtypes have prompted interest in the assessment of individual amino acids. We examined the associations of dietary amino acids with risks of ischaemic and haemorrhagic stroke in the EPIC study. Methods: We analysed data from 356,142 participants from seven European countries. Dietary intakes of 19 individual amino acids

Purpose of reviewSmall cell lung cancer (SCLC) is marked by an exceptionally high proliferative rate and poor prognosis. Given its high propensity to metastasize, nearly two-thirds of SCLC patients are diagnosed with extensive-stage (ES) disease when surgery is not a treatment option anymore. Over several decades, only minimal changes have been made in the therapeutic armamentarium of ES-SCLC. Rec

Prostate cancer is the predominant cause of cancer in men, but there is still a lack of biomarkers and treatments for metastatic spread. The initial promise of microRNAs to provide avenues to solve these problems has been dampened by the realisation that microRNAs co-exist in multiple functionally distinct isoforms, for example due to A-to-I editing. We recently found that A-to-I-editing of microR

Målet med detta projekt var att studera hur tre församlingar i tre kyrkliga miljöer – Odarslövskyrka (Torns församling), Ignaberga nya kyrka (Hässleholms församling), och Östra Nöbbelövs kyrka (Simrishamns församling) i Lunds stift – skulle kunna utveckla sina kyrkliga miljöer för egen del och i samverkan för att öka tillgängligheten till de kyrkliga miljöerna och utveckla dem till meningsfulla anThe objective of this project was to study how three congregations/parishes in three church environments – Odarslövs kyrka (Torn’s parish), Ignaberga nya kyrka (Hässleholm’s parish), and Östra Nöbbelövs kyrka (Simrishamn’s parish) in the Diocese of Lund – could develop the church environments under their auspices in order to increase their accessibility and forms of meaningful use for members of t

Sharing travel experience on social media has become an important element of many people’s lifestyle, whether it be as a hobby, personal expression, economic rewards or other purposes. While previous studies have extensively investigated the significant role of social media in the sharing of travel experience and how it influences the travel decisions of others, very little research has examined o