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Head organizer : Cerberus and IGF cooperate in brain induction in Xenopus embryos
Neural induction by cell-cell signaling was discovered a century ago by the organizer transplantations of Spemann and Mangold in amphibians. Spemann later found that early dorsal blastopore lips induced heads and late organizers trunk-tail structures. Identifying region-specific organizer signals has been a driving force in the progress of animal biology. Head induction in the absence of trunk is
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Normative Reference Equations for Breathlessness Intensity during Incremental Cardiopulmonary Cycle Exercise Testing
Rationale: Cardiopulmonary exercise testing (CPET) is the gold standard to evaluate exertional breathlessness, a common and disabling symptom. However, the interpretation of breathlessness responses to CPET is limited by a scarcity of normative data. Objectives: We aimed to develop normative reference equations for breathlessness intensity (Borg 0–10 category ratio) response in men and women aged
The Ordovician Tøyen Shale (Floian) and its graptolite fauna at Kinnekulle, Västergötland, Sweden–a regional overview
The graptolites of the Tøyen Shale Formation of Kinnekulle in Västergötland, south-central Sweden, are described for the first time and their biostratigraphic distribution is documented from drill core and outcrop material. The faunas indicate an age of mid to late Floian (Billingenian), thus showing a reduced biostratigraphic range of the Tøyen Shale as compared to other areas where this rock uni
Effect of Neprilysin Inhibition on Alzheimer Disease Plasma Biomarkers : A Secondary Analysis of a Randomized Clinical Trial
Amyloid-β (Aβ) accumulation is critical in Alzheimer disease (AD), and neprilysin is involved in physiologically clearing Aβ. Concerns exist regarding long-term use of sacubitril/valsartan, a neprilysin inhibitor and angiotensin receptor blocker used for heart failure, and its potential to increase AD risk. We evaluated neprilysin inhibition’s effect on AD blood biomarkers in patients with coronar
ESMO Clinical Practice Guideline interim update on the use of targeted therapy in acute lymphoblastic leukaemia
An Optimization Model for the Placement of Mobile Stroke Units
Mobile Stroke Units (MSUs) are specialized ambulances that can diagnose and treat stroke patients; hence, reducing the time to treatment for stroke patients. Optimal placement of MSUs in a geographic region enables to maximize access to treatment for stroke patients. We contribute a mathematical model to optimally place MSUs in a geographic region. The objective function of the model takes the tra
Sweden "Go Jimmie go!" : The voices of Sweden Democrat supporters
The Sweden Democrats is a nationalist right-wing populist party with roots in neo-Nazism and white supremacist beliefs. The party has experienced continuous progress during the last decade in Sweden, attracting 20.5 per cent of the vote in the general election of 2022. A combination of discourse analytical methods is applied to study the comment sections of the party's official social media accoun
Cosmologies of conquest : The Renaissance foundations of modern international thought
This paper seeks to reconstruct the worldview informing Iberian overseas expansion during the long sixteenth century, arguing that this worldview was more indebted to Renaissance cosmology than to a recognisably modern scientific worldview. The paper describes how this cosmology provided the intellectual resources necessary to justify overseas expansion to those who doubted its viability and legit
Higher versus lower oxygenation targets in adult ICU patients : A rapid practice guideline
The aim of this Intensive Care Medicine Rapid Practice Guideline (ICM-RPG) was to provide evidence-based clinical guidance about the use of higher versus lower oxygenation targets for adult patients in the intensive care unit (ICU). The guideline panel comprised 27 international panelists, including content experts, ICU clinicians, methodologists, and patient representatives. We adhered to the met
Pulmonary function and atherosclerosis in the general population : causal associations and clinical implications
Reduced lung function is associated with cardiovascular mortality, but the relationships with atherosclerosis are unclear. The population-based Swedish CArdioPulmonary BioImage study measured lung function, emphysema, coronary CT angiography, coronary calcium, carotid plaques and ankle-brachial index in 29,593 men and women aged 50–64 years. The results were confirmed using 2-sample Mendelian rand
Genomic basis of melanin-associated phenotypes suggests colour-specific environmental adaptations in tawny owls
Feathers comprise a series of evolutionary innovations but also harbour colour, a key biological trait known to co-vary with life history or complex traits. Those relationships are particularly true in melanin-based pigmentation species due to known pleiotropic effects of the melanocortin pathway – originating from melanin-associated phenotypes. Here, we explore the molecular basis of melanin colo
Can Return Migration Be a ‘Brain Gain’ for Uzbekistan?
Evaluating and Improving Rendered Visual Experiences : Metrics, Compression, Higher Frame Rates & Recoloring
Rendered imagery is presented to us daily. Special effects in movies, video games, scientific visualizations, and marketing catalogs all often rely on images generated through computer graphics. However, with all the possibilities that rendering offers come also a plethora of challenges. This thesis proposes novel ways of evaluating the visual errors caused when some of those challenges are not co
STREAM Periodic Country Report: Sweden
STREAM Research Brief Sweden
By-passing the National Level? Municipalities as Legal Actors in Multi-Level Governance in Norway and Sweden
This article aims at illuminating the role of Swedish and Norwegian municipalities as legal actors in multi-level governance. The research questionis threefold: What is the role of Swedish and Norwegian municipalities as legal actors in relation to the European level? How do these roles affect local autonomy at the national level? What is the impact of the different affiliations at the European le
Förbättrade arbetsvillkor och utrymmet för solidaritet mellan arbetstagare : ett perspektiv på medborgarskap i ett föränderligt EU
Embracing the academic–practice gap : Knowledge collaboration and the role of institutional knotting
Collaboration between academia and practice is crucial for addressing complex societal challenges and generating new knowledge. However, bridging the perceived gap between these two domains has proven challenging due to differences in language, expectations, and time horizons. In this article, we question the usefulness of framing these differences as a gap and explores alternative approaches to f