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Large strain phase-field based multi-material topology optimization

A multi‐material topology optimization scheme is presented. The formulation includes an arbitrary number of phases with different mechanical properties. To ensure that the sum of the volume fractions is unity and in order to avoid negative phase fractions, an obstacle potential function, which introduces infinity penalty for negative densities, is utilized. The problem is formulated for nonlinear

Hybrid heterogeneous phantoms for biomedical applications: a demonstration to dosimetry validation

Phantoms simultaneously mimicking anatomical and optical properties of real tissues can play a pivotal role for improving dosimetry algorithms. The aim of the paper is to design and develop a hybrid phantom model that builds up on the strengths of solid and liquid phantoms for mimicking various anatomical structures for prostate cancer photodynamic therapy (PDT) dosimetry validation. The model com

Comparison of immunoassay- with mass spectrometry-derived p-tau quantification for the detection of Alzheimer’s disease pathology

Background: Antibody-based immunoassays have enabled quantification of very low concentrations of phosphorylated tau (p-tau) protein forms in cerebrospinal fluid (CSF), aiding in the diagnosis of AD. Mass spectrometry enables absolute quantification of multiple p-tau variants within a single run. The goal of this study was to compare the performance of mass spectrometry assessments of p-tau181, p-

Distinct microRNA Signature and Suppression of ZFP36L1 Define ASCL1-Positive Lung Adenocarcinoma

Achaete-scute family bHLH transcription factor 1 (ASCL1) is a master transcription factor involved in neuroendocrine differentiation. ASCL1 is expressed in approximately 10% of lung adenocarcinomas (LUAD) and exerts tumor-promoting effects. Here, we explored miRNA profiles in ASCL1-positive LUADs and identified several miRNAs closely associated with ASCL1 expression, including miR-375, miR-95–3p/m

Volumetric Lagrangian temperature and velocity measurements with thermochromic liquid crystals

We propose a Lagrangian method for simultaneous, volumetric temperature and velocity measurements. As tracer particles for both quantities, we employ encapsulated thermochromic liquid crystals (TLCs). We discuss the challenges arising from color imaging of small particles and present measurements in an equilateral hexagonal-shaped convection cell of height h = 60 mm and distance between the parall

Sustainable accessibility : last-mile SC challenges and opportunities in B2C renting models

Achieving sustainable development and achieving Agenda 2030 goals requires drastic socio-technical changes, where one of the main challenges is to shift from the dominant linear and transaction-based business logic to a logic of circularity and resource-maximization. In the circular economy era, there are a growing number of actors offering consumers the opportunity to rent products instead of buy

The impact of the great emigration on the Swedish economy

In the half-century before 1914 wages in Sweden advanced from below the West European average to being at a level with those in Britain. This remarkable record has seldom been addressed, but the very rapid concurrent Swedish economic growth is well known. The present article argues that the increase in wages was not only due to industrialisation, but that another major factor was the trans-Atlanti

Health position paper and redox perspectives - Disease burden by transportation noise; Noise, disease, and redox processes

Transportation noise is a ubiquitous urban exposure. In 2018, the World Health Organization concluded that chronic exposure to road traffic noise is a risk factor for ischemic heart disease. In contrast, they concluded that the quality of evidence for a link to other diseases was very low to moderate. Since then, several studies on the impact of noise on various diseases have been published. Also,

Pre- and Postoperative Antioxidant Use, Aryl Hydrocarbon Receptor (AhR) Activation and Clinical Outcome in Different Treatment Groups of Breast Cancer Patients

BACKGROUND: Cancer patients often use antioxidants that may interact with adjuvant treatments. The purpose was to investigate pre- and postoperative antioxidant use in relation to clinicopathological characteristics and prognosis in different breast cancer treatment groups.METHODS AND PATIENTS: Pre- and postoperative antioxidant (vitamin A, C, E, carotenoids, or Q10) or multivitamin use was self-r

Highly efficient eco-friendly sodium titanate sorbents of Cs(i), Sr(ii), Co(ii) and Eu(iii) : synthesis, characterization and detailed adsorption study

Development of useful all-around materials which can quickly and efficiently adsorb radionuclides in response to environmental radioactive contamination is an urgent research objective. In response to this need, our team developed a simple preparation method for stable sodium titanates which can serve as efficient agents for removal of radionuclides from water. With an emphasis on an environmental

Dynamic visual noise has limited influence on the habitat selection and behavioural activity of crustaceans and cephalopods

Environments contain various forms of noise that can interfere with the ability of animal sensory systems to perceive information. One ubiquitous type of visual noise in shallow aquatic habitats is caustic flicker (or caustics), consisting of dynamically moving light patterns caused by the refraction of light when passing through the water's rippling surface. While some teleost fish avoid environm

Revisiting bicoid function : complete inactivation reveals an additional fundamental role in Drosophila egg geometry specification

Introduction: The bicoid (bcd) gene in Drosophila has served as a paradigm for a morphogen in textbooks for decades. Discovered in 1986 as a mutation affecting anterior development in the embryo, its expression pattern as a protein gradient later confirmed the prediction from transplantation experiments. These experiments suggested that the protein fulfills the criteria of a true morphogen, with t

The use and usefulness of point-of-care tests in patients with pharyngotonsillitis – an observational study in primary health care

Background: Rapid antigen detection tests (RADT) for Group A streptococci (GAS) and point-of-care tests for C-reactive protein (CRP) are commonly used in patients with pharyngotonsillitis in Sweden and Denmark although CRP testing is not supported by guidelines. We aimed to describe (1) the proportion of patients tested with RADT and/or CRP, (2) the relation between test results and antibiotic pre