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Bright and efficient blue emission is key to further development of metal halide perovskite light-emitting diodes. Although modifying bromide/chloride composition is straightforward to achieve blue emission, practical implementation of this strategy has been challenging due to poor colour stability and severe photoluminescence quenching. Both detrimental effects become increasingly prominent in pe
Iron deposition is present in main lesion areas in the brains of patients with Parkinson’s disease (PD) and an abnormal iron content may be associated with dopaminergic neuronal cytotoxicity and degeneration in the substantia nigra of the midbrain. However, the cause of iron deposition and its role in the pathological process of PD are unclear. In the present study, we investigated the effects of
To clarify the structure of genetic risks for 11 major psychiatric disorders, we calculated, from morbidity risks for disorders in 1st–5th degree relatives controlling for cohabitation effects, in the Swedish population born between 1932 and 1995 (n = 5,830,014), the family genetic risk scores (FGRS) for major depression (MD), anxiety disorders (AD), obsessive-compulsive disorder (OCD), bipolar di
Background: The aim of this study was to identify factors predicting outcome in patients with mitochondrial disease admitted to pediatric intensive care units (PICU). Methods: Retrospective study of 2434 patients (age <21 years) admitted to a PICU from 1 January 2006 through 31 March 2016 and captured in the Virtual Pediatric Systems database with ICD9 diagnosis 277.87, disorders of mitochondrial
Mantle cell lymphoma (MCL) is characterized by marked differences in outcome, emphasizing the need for strong prognostic biomarkers. Here, we explore expression patterns and prognostic relevance of circular RNAs (circRNAs), a group of endogenous non-coding RNA molecules, in MCL. We profiled the circRNA expression landscape using RNA-sequencing and explored the prognostic potential of 40 abundant c
PCR of TCR/Ig gene rearrangements is considered the method of choice for minimal residual disease (MRD) quantification in BCP-ALL, but flow cytometry analysis of leukemia-associated immunophenotypes (FCM-MRD) is faster and biologically more informative. FCM-MRD performed in 18 laboratories across seven countries was used for risk stratification of 1487 patients with BCP-ALL enrolled in the NOPHO A
Bitumen är den tyngsta produkten från raffinaderier. Den är användbar som bindemedel för olika ytbeläggningar som t.ex. asfalt på vägar, takpapp m.m. Företag Nordic Waterproofing tillverkar takpapp i Höganäs och använder bitumen som en av de viktigaste råvarorna i processen. Ett förnyelsebart samhälle är dagens fokusmål för alla, inte bara enskilda personer, utan hela landet och hela planet måste Nordic Waterproofing is one of the largest roofing felt producers in Europe. One of the production facility is located in Höganäs (Sweden), which is specialized in roofing felt that are suitable for the nordic climate. Bitumen is a central component of roofing felt manufacturing that contribute several properties to the product. Due to the importance of bitumen, Nordic Waterproofing finds an addit
Hur medicinen ser på och benämner intersexpersoner, d.v.s. personer som föds med kroppsliga variationer gällande könskaraktäristika, inklusive hormonella och/eller anatomiska och kromosomala variationer, vilka inte avläses som typiskt manliga eller kvinnliga får direkta konsekvenser för dessa människor i form av kirurgiska ingrepp och andra behandlingar. Ofta sker ingreppen på barn som inte har mö
Datoranalys av cellernas eget flagg-system kan bidra till forskningen kring patient-anpassade cancerbehandlingar Tänk dig att du zoomar in på cellytan utav dina celler. Något som du kommer lägga märke till är uppradade molekyler med små utstickande protein-stumpar (peptider). De står nästan som flaggstänger med viftande flaggor i olika former. Dessa ”flaggstänger” kallas för MHC molekyler och de The exceptionally polymorphic Human Leukocyte Antigen (HLA) genes play a crucial role in the immune system’s interplay with non-immune cells. Certain HLA alleles are known to have a strong disease correlation. There is a growing interest, within several research fields, in determining (typing) HLA alleles at higher resolution than what is possible today using standard laboratory methods. Within th
SLAP2: A potential new strategy in fighting cancer Among more than 20,000 genes in humans, about 2% of genes encode a class of proteins referred to as kinases. A kinase is a protein, which transfers phosphate groups to proteins called substrate proteins. This process is named phosphorylation and almost all cellular behaviors are controlled by protein phosphorylation. Kinases mainly phosphorylate
Like with printers, material used for 3Dprinting is what makes it expensive, especially if the printer is meant to be lowcost. Can used tires be the solution? This thesis proves that old tires can be turned into a usable granulate, with simple means. Then 3Dprinting could be made accessible to people of lesser means.
When evaluating future technologies for smart metering and automatic meter reading (AMR) E.ON Elnät Sverige AB has set up a pilot to test a communication technology supplied by Connode AB. Connode have developed a mesh radio solution based on 6LoWPAN, IPv6 over Low Powered Wireless Personal Area Network. By using this technology the communication unit on every meter is acting as both receiver and
Innovation is gospel today. This also means a surge in popularity for the agents behind innovation; innovators. But who are they, exactly? Anecdotal evidence from both recent times and historical settings tend to emphasize remarkable individuals, who more or less alone created amazing things. By utilizing the SWINNO-database of innovations, this thesis examines how empirically prevalent the narrat
Dividing wall columns are single shell distillation columns which are thermally fully coupled. DWC has the ability to create three product streams from one feed stream. A simulation of DWCs is hard due to the complexity of the system. Unfortunately, there is no good software package that can be used for simulations. Instead a detailed flowsheet with the right components and good arrangement over t
I en allt mer energieffektiv värld så spelar allt fler av energiförlusterna allt större roll. Tidigare hade man samma förluster som idag från kanalsystemet men de totala förlusterna var större. När man nu har minskat andra förluster i huset får kanalför- lusterna en allt större betydelse i den totala energianvändningen, vilket leder till att det nu finns anledning att ta större hänsyn till dem. I To minimize energy losses becomes more and more important in a world where energy efficiency is a big priority and necessary if we want a future on our planet. The relative impact from ducting losses on the energy performance of the building was earlier so small that it was plausible to ignore them. Nowadays many of the other parts of the losses have been cut which means the air ducts now might st
“Alla har en relation till odling och mat, oavsett om man kommer från Somalia, Irak eller Nydala i Malmö.” (Jimenez, 2012). Visst är det så! Att mat är något som vi alla har gemensamt och som förenar människor har varit utgångspunkten för detta arbete. Projektet har resulterat i ett sprudlande matcentrum i Nyhamnen i Malmö. Här kan människor från stadens alla hörn och besökare utifrån samlas krinThe fact that food is something that we all have in common and that it brings people together has been the starting point for this thesis work. The project has resulted in a vibrant food center in the future city district Nyhamnen in Malmö. Here people from all over the city can gather around the People’s Kitchen and Diner, a wine bar, urban farming facilities, food markets and more. The inspirati
Global warming and climate change is getting a serious issue and a great environmental threat that affects many aspects of life and our ways of living on this planet. The negative effects of climate change are endangering our communities, health and economy. Global warming can be considered as a main reason for sea rising levels, extreme heat which is responsible for many forests’ fires, severe dr
