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Huntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Research efforts to understand and treat the disease have historically focused on neuronal pathology, but growing evidence underscores the critical role of oligodendrocytes in its pathogenesis. This review synthesizes recent findings on oligodendroglial dysfuncti
III-Nitride high-electron mobility transistors (HEMTs) grown on AlN substrates offer significant advantages for high-power, high-frequency applications due to AlN high thermal conductivity and ultra-wide bandgap. However, achieving high-quality thin GaN channel layers on AlN is challenging because of lattice mismatch, which leads to columnar growth. In this work, we present the development of a tw
This thesis examines queer community archives (QCAs) and their governing documents in order to gain a better understanding of how they define themselves, their work, and the communities they serve. Focusing on archives associated with queer, leather, BDSM, and fetish communities, specifically The Queer Movement Archives and Library (QRAB) and the Leather Archives & Museum (LA&M), it examin
Among the most advanced techniques for quality control, image processing and optical methods areprominent because of their precision and versatility. These methods often involve analyzing specklesgenerated by coherent laser illumination because coherent light provides detailed and accuratemeasurement capabilities. In speckle metrology-based techniques, the accurate measurement ofspeckle displaceme
Pulmonary fibrosis remains a devastating and often fatal condition due to the lack of effective treatments that halt disease progression. Rodent models of pulmonary fibrosis are crucial to identify candidate targets and novel therapeutic agents. However, the attrition rate of novel drug candidates in clinical trials remains high. This review suggests complementing traditional methods used to evalu
Background: Drug-related problems are common in older individuals. A medication reconciliation has the goal of identifying and maintaining an accurate medication list and can serve to prevent drug-related problems caused by discrepancies. Objectives: This study aimed to explore primary care physicians’ intentions towards performing medication reconciliation in patients with multimorbidity using a
Over the last two decades, the social identity of the jihadist has become a central part of street culture. Depictions of jihadists can be found in popular music, movies and media reports. Propaganda celebrating or condemning jihadism circulates online, and a significant number of individuals with a background in street crime have flirted with or converted to jihadism. Drawing on ethnographic fiel
Bakgrund: Barn utsätts dagligen för smärtsamma procedurer inom barnsjukvården och obehandlad smärta kan leda till ökad smärtkänslighet i framtiden. Studier poängterar vikten av att nyttja evidensbaserade riktlinjer gällande multimodal smärtbehandling för att förebygga procedursmärta. Begränsat antal studier finns i Sverige om sjuksköterskans upplevelse av att arbeta utifrån riktlinjer vid smärtsam
Bakgrund: Andelen barn som ammas i Sverige minskar. För att gynna amning och de positiva hälsoeffekter både barn och moder erhåller genom amning är stöd från partnern centralt. Genom att öka kunskapen hos hälso- och sjukvårdspersonal kan stöd till modern anpassas. Syfte: Syftet var att belysa vilket stöd mödrar önskar få av sin partner under amningsperioden. Metod: En kvalitativ studiedesign med
PurposeThe benefit of adding concurrent systemic therapy to definitive radiation therapy (RT) for patients with T1-2 oropharyngeal squamous cell carcinoma (OPSCC) and limited neck node involvement is uncertain. This study investigates whether chemotherapy (CRT) in patients with early-stage (T1-2) low-volume nodal disease (Union for International Cancer Control Seventh Edition N1-2b) improves overa
BACKGROUND AND OBJECTIVE: Virtual reality (VR) is a rapidly evolving technology that is currently utilized in hospital settings for various types of surgical procedures. The extent to which VR is evident in improving patient outcomes is unknown. This systematic review assesses the impact of VR on adult patients undergoing elective surgical procedures.DATABASES AND DATA TREATMENT: The following dat
Background/Objectives: Electroencephalography (EEG) is increasingly used in pediatric anesthesia to detect abnormal brain activity such as burst suppression (BS), a marker of profound cortical inactivation. The objective of this study was to assess anesthetic depth using bilateral spectral edge frequency (SEF) and to determine the incidence of frontal cortical BS in young children undergoing cardi
BACKGROUND: Wolff-Parkinson-White (WPW) syndrome is a rare cardiac disorder that predispose to supraventricular arrhythmias. Prognosis is usually benign, yet there is an increased lifetime risk of sudden death. While typically sporadic, familial clustering has been reported. This study aimed to assess the risk of WPW, arrhythmias, and mortality among siblings of individuals with WPW.METHODS: This
OBJECTIVES: Ultra-high dose rate irradiation (UHDR) has been shown to spare normal tissue in various model systems. This study evaluates its potential to sterilize cancer cells using spheroid tumor models.METHODS: Spheroids from glioblastoma (U87), hypopharyngeal squamous cell carcinoma (two sizes, FaDusmall and FaDularge) and breast adenocarcinoma (T47D) cells were irradiated with electron beams
Small independent (indie) game startups face fierce competition when developing games with limited time, budget, and resources. Continuously testing and experimenting with new ideas, features, and content is essential to validate and guide development toward a viable and successful game. Such continuous experimentation (CE) requires access to users and user data, which is often very limited in the
We explore vibe coding as a rapid prototyping approach powered by generative AI. We discuss how it lowers the barrier to creating high-fidelity prototypes, enabling nontechnical users to build apps, and examine its implications for communication, validation, and iterative software design.
