Nucleic acid therapies represent a groundbreaking approach in modern medicine, capable of potentially curing previously untreatable diseases by modifying gene expression at the DNA or RNA level. Despite their promise, effective delivery of these therapies remains a significant hurdle. Addressing this challenge is the central mission of the soon-to-be-established Chalmers Precision HealthTech Hub.

A central part for organizations in achieving intended strategies and successfully executing projects is project portfolio management (PPM). However, many companies fail to effectively manage projects related to strategy, and a little research has focused on the realization of PPM regarding organizational development. To gain further understanding of how PPM can contribute to a higher efficiency

The High Luminosity-Large Hadron Collider (HL-LHC) will reach an approximate pile-up of 200 collisions per bunch crossing, ten times more than the current Large Hadron Collider. Beginning operation at the end of the decade, it will accumulate 3000 fb−1, increasing the chances of observing new processes and allowing measurement of rare processes with higher precision. Moreover, the pile-up increase

The Light Dark Matter eXperiment is a fixed target missing-momentum experiment that searches for light dark matter production via the process of Dark Bremsstrahlung by analysing the energy of beam electrons after they hit a tungsten target. Electron counting is an important part of the experiment as this forms one of the two components of the missing energy trigger. The thesis looks into viability

This paper focuses on constructing models that predict a Value at Risk (VaR) estimation for financial portfolios using hierarchical clustering and copulas. Traditional VaR models often assume linear dependencies and normal distributions, which can be poor assumptions for financial data - especially during extreme market events. This paper introduces a non-linear modeling approach using copulas to

This thesis investigates the development of an innovative eco-smart cabin for the Smart dishwasher, undertaken in collaboration with Nordisk Clean Solutions. The primary research objectives were to explore the possibilities of reducing costs, weight, welding requirements, and assembly time while evaluating the environmental impacts of the new design. Key research questions focused on whether these

This thesis explores how to design vehicle restraint systems specifically for Nordic climates. Cargo trucks prematurely departing from loading bays can cause serious damage to goods and personnel. To combat this problem vehicle restraint systems are commonly used to physically keep the trucks in place. However, many of these systems require permanent installations in front of the loading dock, mak

This body of work covers the utility of the development of a tool for automatically configuring the transistors in an existing netlist, according to a set of specifications. By swapping out transistors for transistors with other Voltage Thresholds it can achieve target speeds with acceptable accuracy and reduce the static power consumption of a circuit. To make this process feasible, the tool uses

Traditionell produktutveckling har en tendens att förlita sig på fysiska prototyper och produkttester för att kunna presentera koncept, förbättra design och kalibrera tillverkningsinställningar. Detta projekt undersöker och utvärderar en virtualisering av prototypframtagning och testning av en plastprodukt för att se om det kan resultera i en snabbare produktframtagning och besparingar av utveckliTraditional product development tends to heavily rely on physical prototyping and testing to present concepts, improve design, and calibrate manufacturing settings. This project aims to explore and evaluate a virtualization of prototype development and testing of a plastic product to evaluate if it results in a faster product development process and savings in development costs, as well as a more

This study investigates the perceptions and implementation of AI ethics principles among AI practitioners in the Bangladeshi IT sector. Through qualitative research, including semi-structured interviews with key informants, the study reveals significant variations in awareness and application of AI ethics principles such as fairness, privacy, transparency, robustness, and explainability. The findi

This study explores the perceptions of graphic designers regarding the impact of generative artificial intelligence (GenAI) on their profession. It aims to highlight practical examples of how GenAI is integrated into the work of graphic designers. To achieve this, qualitative data was collected through semi-structured interviews with six professional graphic designers. The findings reveal that the

Durable and robust product development is crucial for fulfilling customer expectations and ensuring satisfaction. In this context, thorough testing plays an essential role in identifying and addressing potential defects before products reach the final customer. IKEA, with its worldwide presence, aims to enhance its understanding of humidity's impact on kitchen fronts, one of the main product a

Detta examensarbete genomfördes i samarbete med Ekbacken Studios, ett företag som är specialiserat på tillverkning av hemmöbler tillverkade med 3D-printning av återvunnen plast. Begäran från företaget att lägga till hallmöbler till sin produktlinje resulterade i projektets omfattning. För att möta denna begäran genomfördes ett examensarbete för att utveckla ett koncept för hallmöbler, med särskild

Synthetic data is becoming more accessible and presents several benefits over traditional human-derived data for developing healthcare technology, especially in medical imaging systems. The primary reasons for using synthetic data are to minimise the potential privacy risks associated with real human data and to substantially increase the overall volume of available data. Previous research has lar

The bioenergy industry, particularly pulp mills, holds promise for achieving carbon negativity through the adoption of carbon capture processes. Presently, CO2 capture from flue gases poses significant challenges due to its energy-intensive nature and the risk of solvent chemical degradation. This thesis conducts a screening of primary absorption technologies and models a carbon capture process in

This is an explorative and, at times, tentative text on the potential meanings and uses of the concept Existential Sustainability in social work and social work research. The overall argument is that to create a positive change in the lives of people in general, service users more specifically, and to sustain such change over time, it is necessary to acknowledge an existential dimension and existeThis is an explorative and, at times, tentative text on the potential meanings and uses of the concept Existential Sustainability in social work and social work research. The overall argument is that to create a positive change in the lives of people in general, service users more specifically, and to sustain such change over time, it is necessary to acknowledge an existential dimension and existe

This is the data and code from a word-monitoring task, in which advanced learners of English responded to the word 'to' in verb + to-infinitive structures (V-to-Vinf) in English, where 'to' could occur in a full or reduced pronunciation (e.g. "prefer to" [tʊ] or "preferda" [ɾə]). The design of this experiment is replicated from our earlier study with American English native speakers (Lorenz &

The present study highlights two important parameters of flute playing and musicalexpression: Sound and Articulation

The present study being the second volume of Variations on Ah! vous dirai-je, Maman (2019) highlights two important parameters of flute playing and musical expression: On Practice, Intervals and Sons filés.

The present study being the third volume of Variations on Ah! vous dirai-je, Maman (2020) highlights four important parameters of flute playing: Timbre, Expression, Resonance and Projection.