Introduction A recent genome-wide association study in European systemic sclerosis (SSc) patients identified three loci (PSORS1C1, TNIP1 and RHOB) as novel genetic risk factors for the disease. The aim of this study was to replicate the previously mentioned findings in a large multicentre independent SSc cohort of Caucasian ancestry. Methods 4389 SSc patients and 7611 healthy controls from differe

Novel field effect transistors with suspended graphene gates are demonstrated. By incorporating mechanical motion of the gate electrode, it is possible to improve the switching characteristics compared to a static gate, as shown by a combination of experimental measurements and numerical simulations. The mechanical motion of the graphene gate is confirmed by using atomic force microscopy to direct

Background: Serum creatinine-based estimates of GFR may be inaccurate in the elderly and there is need for improvement. Serum Cystatin C, not being influenced by muscle volume, may be more accurate. Material and methods: GFR was measured with plasma clearance of iohexol in 50 elderly persons aged >70 years. Blood tests were drawn for analysis of creatinine, albumin and urea. Cystatin C was analyse

Despite anti-dsDNA antibodies constitute a wide range of specificities, they are considered as the hallmark for systemic lupus erythematosus (SLE).

Measurements of fiducial and differential cross sections of Higgs boson production in the H -> ZZ* -> 4l decay channel are presented. The cross sections are determined within a fiducial phase space and corrected for detection efficiency and resolution effects. They are based on 20.3 fb(-1) of pp collision data, produced at root s= 8 TeV centre-of-mass energy at the LHC and recorded by the ATLAS de

BACKGROUND: Mechanisms regulating the ABO gene are unclear, especially in the hematopoietic compartment. The number of 43-bp repeats in the CBF/NF-Y-binding enhancer region is considered to have a major influence on transcription. STUDY DESIGN AND METHODS: Transcript levels in peripheral blood and in erythropoietic culture of CD34+ cells from marrow donors were measured with TaqMan assays. The 5'-

Aim: The aim of this study was to describe asylum seekers' satisfaction with daily occupations and activity level while in a Danish asylum centre, and whether this changed over time. Another aim was to describe whether exposure to torture, self-rated health measures, and ADL ability were related to their satisfaction with daily occupations and activity level. Methods: A total of 43 asylum seekers

It is recognized that cooling methods incorporating micro-channel heat sinks with high capacities of heat removal are necessary for cooling of electronic devices. In this paper, based on a water-cooled smooth micro-channel heat sink, a series of rectangular-shaped flow obstructions are designed into a heat sink, and then the corresponding laminar flow and heat transfer have been analyzed numerical

This article is devoted to introduce a new class of nonassociative algebras with involution including the class of structurable algebras.

It has been reported that there is a difference in drug prescription between males and females. Even after adjustment for multi-morbidity, females tend to use more prescription drugs compared to males. In this study, we wanted to analyse whether the gender difference in drug treatment could be explained by gender-related morbidity.

The dynamic properties of the glomerular filtration barrier (GFB) are of fundamental importance for the understanding of the physiology and pathophysiology of microalbuminuria and proteinuric diseases. In the studies of this doctoral thesis the properties of the rat glomerular filtration barrier were investigated under resting conditions and following a number of challenges using highly sensitive

The recently identified phylogenetic subgroup B5 of fungal glycoside hydrolase family 18 genes encodes enzymes with mannosyl glycoprotein endo-N-acetyl-b-D-glucosaminidase (ENGase)-type activity. Intracellular ENGase activity is associated with the endoplasmic reticulum associated protein degradation pathway (ERAD) of misfolded glycoproteins, although the biological relevance in filamentous fungi

Popular Abstract in Swedish Det finns ett flertal hormoner som bildas i mag-tarmkanalen och som sedan frisätts till blodet i samband med måltidsintag. Runtom i kroppen finns det sedan målceller, så kallade receptorer, som stimuleras av hormonerna till att påverka olika processer i kroppen. De hormoner från mag-tarmkanalen som vi har studerat är de så kallade inkretinhormonerna, glukagon-lik peptidSeveral different hormones are released from the intestine following a meal. In this thesis we have focused on the so called incretin hormones, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). An important function of the incretin hormones is potentiation of insulin release from pancreatic beta-cells following a meal. This property has attracted a lot of inte

Colorectal cancer (CRC) is the third most common cancer worldwide with more than 700,000 deaths every year. Prognosis mostly depends on disease stage at diagnosis, however, outcome may vary considerably even within the same stage. Thus, there is a great need for new prognostic biomarkers to better identify patients with a high risk of developing metastases and select right patients for adjuvant tr

This paper presents a technique for reconstructing two interfering wavefronts by analyzing their 3D interference field pattern. The method is based on the numerical inverse problem and will present a robust algorithm for reconstructing of wavefronts. Several simulations are done to validate the proposed method. (C)2011 Optical Society of America

Recensionen lyfter fram bokens variationsrikedom när det gäller analyser av huvudsakligen 1900-talspsalmers text och musik.