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Deficiency in C1 inhibitor (C1INH, SERPING1) is canonically associated with hereditary angioedema (HAE-C1INH) but not thrombosis. To determine the thrombosis risk conferred by loss of C1INH in the general population, we studied genetically-defined C1INH deficiency across 635,823 participants. Functionally deleterious germline coding variation in SERPING1 was rare (~1:10,000), indicating strong gen

Background Childhood vaccination rates fluctuate over time and do not always meet the levels recommended by the WHO. Objective This study aims to provide an overview of measures countries have introduced to increase vaccination rates. Methods We developed a structured data collection template that was completed by country experts from Europe, Israel, the USA, and Canada. Experts were identified us

“Now that it doesn’t come from the phone, where is the money coming from?” asks a member of Wazee Hukumbuka during one of the farmer-cooperative’s community meetings. Silas, a local leader knowledgeable about community currencies answers swiftly. “As Wazee Hukumbuka, you are paying members for their seeds from a sort of cooperative fund. That’s where the money is coming from. It’s just that you ar

Aims: Social science literature suggests that unlimited trust in others may lead to adverse outcomes, and that moderate trust may be more optimal in social interactions. The aim was to analyze associations between generalized trust in other people and all-cause mortality using a four-alternative generalized trust item that includes moderate trust. Study design: Prospective cohort study. Methods: T

Trelleborg fortresses – the dream architecture of the Viking Age. In 1934, few decades after the idea of the existence of Jomsborg had been critically rejected, a geometric Viking fortress was surprisingly discovered on Zealand, named after the site, a so called Trelleborg fortress. This was followed by the search for more fortresses all over Scandinavia, a search that is still ongoing. Their ramp

This chapter provides an overview of how claims for state redress have been articulated by memory activists and handled by representatives of the Nordic states from the 1990s to the 2020s. The main types of historical injustices under scrutiny in these processes of “politics of regret” are enslavement and overseas colonialism, abuse in care settings, and forced assimilation of the Sámi and nationa

Early life air pollution exposure may play a role in development of respiratory infections, but underlying mechanisms are still not understood. We utilized data from two independent prospective birth cohorts to investigate the influence of prenatal and postnatal ambient air pollution exposure of PM2.5, PM10 and NO2 on maternal and child proteomic profiles and the risk of daily diary-registered com

We present a numerical scheme for the solution of the initial-value problem for the “bad” Boussinesq equation. The accuracy of the scheme is tested by comparison with exact soliton solutions as well as with recently obtained asymptotic formulas for the solution.

Firms require multi-stakeholder ecosystems to successfully create and implement circular business models for electric vehicle (EV) battery second life. However, there is a notable absence of guiding instruments to assist EV battery ecosystem actors in formulating and managing strategies for battery second-life operations. This study's aim is to analyze how circular ecosystems are formed and manage

The question of women deacons is a pressing issue in many Catholic and Orthodox churches. While recent scholarly investigations mainly discuss the theological argu- ments or the historical precedent, there are few if any studies which actually take liv- ing practices and real women deacons into account, as in this study of three Syriac Orthodox congregations in Sweden. From a lived religion perspeThe question of women deacons is a pressing issue in many Catholic and Orthodox churches. While recent scholarly investigations mainly discuss the theological arguments or the historical precedent, there are few if any studies which actually take living practices and real women deacons into account, as in this study of three Syriac Orthodox congregations in Sweden. From a lived religion perspectiv

This study featured about the synthesis of graphene oxide hydrogel-CuO@reduced graphene oxide (rGH-CuO@rGO) micromotors with core-shell structure via an ultrasonication-assisted chemical precipitation method and their application for catalytic dye degradation. The micromotors were comprehensively characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron mi

We investigate the computation of stable fracture paths in brittle thin films using one-dimensional damage models with an elastic foundation. The underlying variational formulation is non-convex, making the evolution path sensitive to algorithmic choices. In this paper, we inquire into the effectiveness of quasi-Newton algorithms as an alternative to conventional Newton-Raphson solvers. These algo

Att placeras på HVB är en av de mest ingripande insatserna inom socialt arbete. För ungdomar innebär den ofta att tillvaron blir präglad av förändring och en känsla av att framtiden är osäker. Licentiatuppsatsen fördjupar kunskapen kring existentiella utmaningar som kan uppstå i denna process. Studien har en teoretisk utgångspunkt i existentiell filosofi och fokuserar på hur grundläggande livsvillWhen young people are placed in residential care (HVB) it is one of the mostfar-reaching interventions in social work, often involving significantdisruptions to their everyday lives, future outlook, and sense of self. Whilesuch placements frequently raise questions about meaning and freedom thesechallenges remain largely unexplored from an existential perspective in bothresearch and practice. This

Every day, new decisions are made, ranging from trivial to critical, and their impact can vary greatly. Despite these differences, all decisions share a common goal: to choose the best possible action based on the knowledge available at the time. In some cases, past events offer little insight into what lies ahead. However, in many situations, especially in structured environments, historical patt

Industrial redevelopment has become an increasingly pressing urban challenge as cities expand and central industrial areas are drawn into the evolving urban fabric. While regeneration projects often succeed in giving former industrial sites new roles, the preservation of the industrial legacy is frequently reduced due to the conflicting demands between industrial and central urban functions. What

The eighteenth century marks a watershed in European intellectual history. It witnessed the development of many civil rights ideas that were prerequisites for the emergence of modern political systems. One principle that appears to be supported by numerous empirical examples is that evolving political pluralism fostered the right to express one’s views with a certain degree of freedom. This articl

Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema--a transient structure that houses a pool of progenitor cells that regenerate the missing tissue. We have identified the expression of von Willebrand Factor D and EGF Domains (vwde) as a common feature of blastemas capable of