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LPS induces GROalpha chemokine production via NF-kappaB in oral fibroblasts.

Objective and design Chemotaxis of neutrophils from blood to the inflammation process plays an important role in development of periodontal inflammation. The novel chemokine GRO alpha, also named CXCL1, is a strong chemoattractant for neutrophils. Data on production and regulation of GRO alpha by oral fibroblasts have not previously been presented. Materials and methods GRO alpha mRNA and protein

The effect of alpha-synuclein knockdown on MPP plus toxicity in models of human neurons

The protein alpha-synuclein is central to the pathophysiology of Parkinson's disease (PD) but its role in the development of neurodegeneration remains unclear. alpha-Synuclein-knockout mice develop without gross abnormality and are resistant to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), a mitochondrial inhibitor widely used to model parkinsonism. Here we show that differentiated human do

A multidimensional multispecies continuum model for heterogeneous biofilm development

We propose a multidimensional continuum model for heterogeneous growth of biofilm systems with multiple species and multiple substrates. The new model provides a deterministic framework for the study of the interactions between several species and their effects on biofilm heterogeneity. It consists of a system of partial differential equations derived on the basis of conservation laws and reaction

Approximate distance oracles for geometric spanners

Given an arbitrary real constant epsilon > 0, and a geometric graph G in d-dimensional Euclidean space with n points, O(n) edges, and constant dilation, our main result is a data structure that answers (1 + epsilon)-approximate shortest-path-length queries in constant time. The data structure can be constructed in O( n log n) time using O( n log n) space. This represents the first data structure t

Accumulation of ubiquitin conjugates in a polyglutamine disease model occurs without global ubiquitin/proteasome system impairment

Aggregation-prone proteins have been suggested to overwhelm and impair the ubiquitin/proteasome system (UPS) in polyglutamine (polyQ) disorders, such as Huntington's disease (HD). Overexpression of an N-terminal fragment of mutant huntingtin (N-mutHtt), an aggregation-prone polyQ protein responsible for HD, obstructs the UPS in cellular models. Furthermore, based on the accumulation of polyubiquit

The role of inter-specific, micro-habitat and climatic factors on the carbon isotope (delta C-13) variability of a modern leaf assemblage from northern Scandinavia: implications for climate reconstruction

To provide a basis for the interpretation of past climatic conditions from Quaternary leaf records, leaf carbon isotope (delta C-13) results are presented for 12 northern European dwarf-shrub, shrub and tree species growing across a network of 18 sites in northern Scandinavia. The role of micro-habitat (hummock/hollow) on carbon isotope trends is explored in addition to a comparison of the carbon

Coupled folding-binding versus docking: A lattice model study

Using a simple hydrophobic/polar protein model, we perform a Monte Carlo study of the thermodynamics and kinetics of binding to a target structure for two closely related sequences, one of which has a unique folded state while the other is unstructured. We obtain significant differences in their binding behavior. The stable sequence has rigid docking as its preferred binding mode, while the unstru

Postischemic exercise attenuates whereas enriched environment has certain enhancing effects on lesion-induced subventricular zone activation in the adult rat

Experimental stroke increases cell proliferation and neurogenesis in the subventricular zone (SVZ) and in the dentate gyrus subgranular zone (SGZ) in the adult mammalian brain. This study examined the effects of postischemic voluntary exercise (running wheel) and environmental enrichment on the SVZ and SGZ 1 week after focal cortical ischemia in adult spontaneously hypertensive rats. Immunohistoch

Polybrominated diphenyl ethers in aircraft cabins - A source of human exposure?

Commercial aircrafts need a high degree of fire protection for passenger safety. Brominated flame retardants (BFRs), including polybrominated diphenyl ethers (PBDEs), may be used for this purpose. Because PBDEs readily absorb to dust particles, aircraft crew and passengers may receive significant PBDEs exposure via inhalation. The aims of this work were to assess whether PBDEs could be found in ai

Correlated dynamics of consecutive residues reveal transient and cooperative unfolding of secondary structure in proteins

Nuclear spin relaxation is a powerful method for studying molecular dynamics at atomic resolution. Recent methods development in biomolecular NMR spectroscopy has enabled detailed investigations of molecular dynamics that are critical for biological function, with prominent examples addressing allostery, enzyme catalysis, and protein folding. Dynamic processes with similar correlation times are of

Collembolan dietary specialisation on soil grown fungi

Preferences of six collembolans for eight species of microfungi grown in soil have been investigated. Collembolans (Folsomia fimetaria, Isotoma anglicana, Isotama notabilis, Heteromurus nitidus, Protaphorura armata, Pseudosinella alba) and microfungi where chosen for the experiment on the basis of their abundance and vertical distribution in an organically grown field where all organisms and soil

Plasmodium falciparum is able to invade erythrocytes through a trypsin-resistant pathway independent of glycophorin B

Plasmodium falciparum invades erythrocytes through multiple ligand-receptor interactions, with redundancies in each pathway. One such alternate pathway is the trypsin-resistant pathway that enables P. falciparum to invade trypsin-treated erythrocytes. Previous studies have shown that this trypsin-resistant pathway is dependent on glycophorin B, as P. falciparum strains invade trypsin-digested glyc

A fast output-sensitive algorithm for Boolean matrix multiplication

We use randomness to exploit the potential sparsity of the Boolean matrix product in order to speed up the computation of the product. Our new fast output-sensitive algorithm for Boolean matrix product and its witnesses is randomized and provides the Boolean product and its witnesses almost certainly. Its worst-case time performance is expressed in terms of the input size and the number of non-zer

Patterns of inbreeding depression in a population of Brassica cretica (Brassicaceae): evidence from family-level analyses

In this investigation, we have collected family-structured data from a partly self-compatible, outcrossing population of Brassica cretica to estimate and compare the effects of one-generation selfing on different types of characters. Inbreeding not only depressed characters that should be positively correlated with fitness irrespective of habitat, e.g. germinability, leaf number and inflorescence

Scaling properties of azimuthal anisotropy in Au plus Au and Cu plus Cu collisions at root s(NN)=200 GeV

Differential measurements of elliptic flow (v(2)) for Au+Au and Cu+Cu collisions at root s(NN)=200 GeV are used to test and validate predictions from perfect fluid hydrodynamics for scaling of v(2) with eccentricity, system size, and transverse kinetic energy (KET). For KET equivalent to m(T)-m up to similar to 1 GeV the scaling is compatible with hydrodynamic expansion of a thermalized fluid. For

A study on turbulent flow characteristics in ducts of relevance for heat exchangers

The performance of an explicit algebraic stress model with a cubic equation for closure constants is assessed in predicting the turbulent flow dynamics of ducts relevant for heat exchangers. The use of a cubic equation allows elimination of any damping functions in the tensor representation for the Reynolds stresses and thereby improves prediction of turbulent stresses theoretically. The methodolo

Scotopic colour vision in nocturnal hawkmoths

Humans are colour-blind at night, and it has been assumed that this is true of all animals. But colour vision is as useful for discriminating objects1 at night as it is during the day. Here we show, through behavioural experiments, that the nocturnal hawkmoth Deilephila elpenor uses colour vision to discriminate coloured stimuli at intensities corresponding to dim starlight (0.0001 cd m-2). It can