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Pharmaceutical Industry Payments to Patient Organizations in Poland : Analysis of the Patterns, Evolution, and Structure of Connections

Drug company funding can create conflicts of interest that compromise the integrity of patient organizations, a problem studied primarily in Western Europe and North America. To address this research gap, we conducted a case study in Poland, a Central European country. Between 2012 and 2020, 33 companies reported payments worth €13 729 644 to 273 patient organizations in Poland. The funding was hi

The complexity of needs and roles of family members during breast cancer rehabilitation : a qualitative study

Background: Family members play a crucial role in supporting women with breast cancer during their recovery. In the complex situation of being an informal caregiver, their own health and ability to support the patient needs to be acknowledged. The aim was to explore the experiences, needs and roles of family members throughout the rehabilitation process of women with breast cancer. Methods: A qual

Five biomarkers from one cerebrospinal fluid sample to stage Alzheimer’s disease

Staging Alzheimer’s disease on the basis of the disease’s biological underpinnings might help with stratification and prognostication, both in the clinical setting and in clinical trials. We propose a staging model based on only five biomarkers, which are related to amyloid-β and tau pathologies in different ways and can be measured with a single sample of cerebrospinal fluid.

Omission of Radiotherapy in Primary Mediastinal B-Cell Lymphoma: IELSG37 Trial Results

PURPOSE The role of consolidation radiotherapy in patients with primary mediastinal B-cell lymphoma (PMBCL) is controversial. METHODS The IELSG37 trial, a randomized noninferiority study, aimed to assess whether irradiation can be omitted in patients with PMBCL with complete metabolic response (CMR) after induction immunochemotherapy. The primary end point was progression-free survival (PFS) at 30

Managing Soil Carbon Sequestration : Assessing the Effects of Intermediate Crops, Crop Residue Removal, and Digestate Application on Swedish Arable Land

Promoting the bioeconomy to aid in the achievement of sustainability goals has increased demand for biomass as feedstock. Residual biomass from agricultural production is an attractive option, as it is a by-product that does not compete with food production. However, crop residues are important for the preservation of soil quality, especially for the maintenance of soil organic carbon. Therefore,

Skuldtyngd – Unga vuxna och skuldens dimensioner : Policy Brief #4, jan 2025. Tema: Överskuldsättning som socialt problem

Skuldtyngd är ett forskningsprojekt som startade 2021 och pågår till och med 2025, i samarbete mellan Lunds universitet och Göteborgs universitet. Projektet är finansierat av Forte och studerar skuldsättningsproblem bland unga vuxna i åldern 18 till 25 år. Centralt för projektet är att förstå skuldsättningen ur unga vuxnas eget perspektiv, liksom att studera skuldsättning som ett socialt och relat

AGREE II Quality Assessment of National and International Clinical Practice Guidelines on Prostate Cancer Management by the OPTIMA Consortium

Background and objective: Clinical practice guidelines for prostate cancer (PCa) are a valuable resource for everyday clinical practice. The clinical practice guidelines and recommendations produced by various societies should demonstrate a considerable level of consistency in terms of quality, regardless of the society that developed these given the common evidence base. However, to date, no stud

Male harm suppresses female fitness, affecting the dynamics of adaptation and evolutionary rescue

One of the most pressing questions we face as biologists is to understand how climate change will affect the evolutionary dynamics of natural populations and how these dynamics will in turn affect population recovery. Increasing evidence shows that sexual selection favors population viability and local adaptation. However, sexual selection can also foster sexual conflict and drive the evolution of

CoopeRIS : A framework for the simulation of reconfigurable intelligent surfaces in cooperative driving environments

Future connected vehicles will require high-performance communication technologies for advanced cooperative driving applications such as maneuvering and cooperative perception. mmWave communications can meet the bandwidth requirements of such applications, but the typically harsh propagation conditions of vehicular environments hinder the broad adoption of mmWave devices on cars. Reconfigurable in

Risk of depression in persons with Alzheimer's disease : A national cohort study

INTRODUCTION: Depression is a risk factor and possible prodromal symptom of Alzheimer's disease (AD), but little is known about subsequent risk of developing depression in persons with AD. METHODS: National matched cohort study was conducted of all 129,410 persons diagnosed with AD and 390,088 with all-cause dementia during 1998–2017 in Sweden, and 3,900,880 age- and sex-matched controls without d

EPOS2020/EUFOREA expert opinion on defining disease states and therapeutic goals in CRSwNP

Severe chronic rhinosinusitis with nasal polyps (CRSwNP), a form of diffuse bilateral (usually type 2) CRS, is a debilitating disease with a significant impact on quality of life (QoL). With novel knowledge and treatment options becoming available, there is a growing need to update or revise key definitions to enable communication across different specialties dealing with CRS, and to agree on nove

Continuous Microwave Photon Counting by Semiconductor-Superconductor Hybrids

We present a continuous microwave photon counter based on superconducting cavity-coupled semiconductor quantum dots. The device utilizes photon-assisted tunneling in a double quantum dot with tunneling events being probed by a third dot. Our device detects both single and multiple-photon absorption events independently, thanks to the energy tunability of a two-level double-dot absorber. We show th

Randomised controlled trial of lifestyle interventions for abdominal obesity in primary health care

Aim: Assess effects on waist circumference from diet with or without cereal grains and with or without long-term physical exercise. Background: Elevated waist circumference is an indicator of increased abdominal fat storage and is accordingly associated with increased cardiovascular mortality. This is likely due to the association between lifestyle-induced changes in waist circumference and cardio

Molecular mechanism of α-synuclein aggregation on lipid membranes revealed

The central hallmark of Parkinson's disease pathology is the aggregation of the α-synuclein protein, which, in its healthy form, is associated with lipid membranes. Purified monomeric α-synuclein is relatively stable in vitro, but its aggregation can be triggered by the presence of lipid vesicles. Despite this central importance of lipids in the context of α-synuclein aggregation, their detailed m

Ambiguity, arguments and visions : First-year teacher student voices on digital teaching during COVID-19

Lund University (Sweden) teacher education students' reflections constitute the foundation for this chapter. The students wrote about their situation, what they could learn from it and how they could bring these lessons into their future roles. The students' voices on digitalisation and isolation in their learning experiences illustrate the importance of belonging and motivation in education. The