Pediatric central nervous system (CNS) tumors represent the most common cause of cancer-related death in children aged 0–14 years. They differ from their adult counterparts, showing extensive clinical and molecular heterogeneity as well as a challenging histopathological spectrum that often impairs accurate diagnosis. Here, we use DNA methylation-based CNS tumor classification in combination with

Copy number (CN) polymorphisms of complement C4 play distinct roles in many conditions, including immune-mediated diseases. We investigated the association of C4 CN with systemic sclerosis (SSc) risk. Imputed total C4, C4A, C4B, and HERV-K CN were analyzed in 26,633 individuals and validated in an independent cohort. Our results showed that higher C4 CN confers protection to SSc, and deviations fr

This abstract describes the decomposition of a matrix representing a scattering dyadic into characteristic modes. Scattering dyadic, as compared to conventionally used impedance matrices, are independent of numerical method used to compute them and the same characteristic mode formulation can be used for decomposition of composite and inhomogeneous materials. The utilization of scattering dyadic m

A novel synthesizing procedure is introduced and employed to extract locally-optimal cloaking devices. Their performance is compared with fundamental bounds found using a convex optimization approach. The optimization method is based on a method-of-moments paradigm utilizing rank-1 updates of the structure iteratively performed based on a greedy algorithm. This approach produces locally optimal sh

The contribution of germline copy number variants (CNVs) to risk of developing cancer in individuals with pathogenic BRCA1 or BRCA2 variants remains relatively unknown. We conducted the largest genome-wide analysis of CNVs in 15,342 BRCA1 and 10,740 BRCA2 pathogenic variant carriers. We used these results to prioritise a candidate breast cancer risk-modifier gene for laboratory analysis and biolog

This abstract presents the versatility and computational effectiveness of characteristic mode decomposition based on the transition matrix. The described treatment is valid for all lossless and linear material distributions and is independent of the numerical method used to resolve a particular scattering scenario.

Glaucoma is a leading cause of blindness. Current glaucoma medications work by lowering intraocular pressure (IOP), a risk factor for glaucoma, but most treatments do not directly target the pathological changes leading to increased IOP, which can manifest as medication resistance as disease progresses. To identify physiological modulators of IOP, we performed genome- and exome-wide association an