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Experimental porcine models of retinal ischemia

Popular Abstract in Swedish Näthinnan (retina) ligger längst bak i ögat och fungerar som filmen i en kamera. Stavar och tappar registrerar ljus och signalen går via nerver till syncentra i hjärnan. Blodkärl löper genom näthinnan och förser cellerna med syre och näring samt transporterar bort slaggprodukter. Kärlsjukdomar, som t.ex. diabetes, blodproppar i näthinnan till följd av åderförkalkning ocRetinal ischaemia resulting from e.g. diabetes, vein thrombosis or arterial occlusion, is one of the major causes of visual impairment and blindness. Although new methods of treatment are being developed, there is still a need for more effective pharmacological forms of treatment. The aim of this work was to develop an appropriate animal model of retinal ischaemia in which the intracellular signal

Changing pattern in the prescription of biological treatment in rheumatoid arthritis. A 7-year follow-up of 1839 patients in southern Sweden

Objective: To study prescription patterns of biological treatment in rheumatoid arthritis ( RA) patients in southern Sweden, a region with no formal or economic restrictions for the use of biological treatment in rheumatological diseases. Specifically, we studied conformity with the national Swedish guidelines for biologics in RA. Methods: Rheumatologists in southern Sweden contribute to a volunta

Mapping the d-d Excited-State Manifolds of Transition Metal beta-Diiminato-Imido Complexes. Comparison of Density Functional Theory and CASPT2 Energetics

Trigonal-planar, middle transition metal diiminato-imido complexes do not exhibit high-spin states, as might be naively expected on the basis of their low coordination numbers. Instead, the known Fe(III), Co(III), and Ni(III) complexes exhibit S = (3)/(2), S = 0, and S = (1)/(2), ground states, respectively. Kohn-Sham DFT calculations have provided a basic molecular orbital picture of these compou

Modeling Morphological Evolution in the vicinity of coastal structures

A numerical model of beach topography evolution was developed. The model includes five sub-models: random wave transformation model, surface roller model, wave-induced current model, sediment transport model, and morphological change model. The model was validated by two unique high-quality data sets obtained from experiments on the morphological impact of a detached breakwater and a T-head groin

Durable Polysulfones with Densely Sulfonated Segments for Highly Proton Conducting Membranes

Popular Abstract in English Fuel cells have been considered as alternative power source to petroleum oil. Especially, fuel cells have potentials to provide no pollutant emission (e.g., CO2, NOx, SOx) out of the power generation. For instance, once the fuel cells are installed instead of combustion engine in the cars used for commuting, transportation and leisure, the amount of pollutant emission cFuel cells are considered as a promising alternative environmentally benign power source to the existing ones depending on petroleum oil. Especially, proton-exchange membrane fuel cells (PEMFCs) have been intensively developed during the last decade because of their wide application windows including various portable, stationary and transportation applications. The market has been and will be main

Distinctive character of electronic and vibrational coherences in disordered molecular aggregates

Coherent dynamics of coupled molecules are effectively characterized by the two-dimensional electronic spectroscopy. Depending on the coupling between electronic and vibrational states, oscillating signals of purely electronic, purely vibrational or mixed character are observed with the help of oscillation maps, constructed from time-resolved spectra. Amplitude of beatings caused by electronic coh

Retigabine as add-on treatment of refractory epilepsy– a cost-utility study in a swedish setting

Abstract in Undetermined OBJECTIVES: To calculate comparative incremental cost-effectiveness ratios (cost per quality-adjusted life year, QALY) and net marginal benefits for retigabine as add-on treatment for patients with uncontrolled focal seizures as compared to add-on lacosamide treatment and no add-on treatment, respectively. MATERIALS & METHODS: Calculations were performed using a valida

Balloon kyphoplasty and vertebroplasty in the management of vertebral compression fractures

Vertebral compression fractures (VCFs) are the most prevalent fractures in osteoporotic patients. The classical conservative management of these fractures is through rest, pain medication, bracing and muscle relaxants. The aim of this paper is to review prospective controlled studies comparing the efficacy and safety of minimally invasive techniques for vertebral augmentation, vertebroplasty (VP)

Long-range angular correlations on the near and away side in p-Pb collisions at root S-NN=5.02 TeV

Angular correlations between charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV for transverse momentum ranges within 0.5 < P-T,P-assoc < P-T,P-trig < 4 GeV/c. The correlations are measured over two units of pseudorapidity and full azimuthal angle in different intervals of event multiplicity, and exp

Austrian lichenologists exploring the Alps

Biographic sketches are provided for 19 of Austrian botanists who contributed in different ways to the knowledge on lichens of the European Alps: Othmar Breuss, Carl Wilhelm von Dalla Torre, Helmut Gams, Georg Gärtner, Martin Grube, Josef Hafellner, Karl von Keissler, Ernst Kernstock, Helmut Mayrhofer, Walter Obermayer, Josef Poelt, Karl Redinger, Julius Steiner, Elfriede Stocker-Wörgötter, Elisab

Comparison of end-point continuum-solvation methods for the calculation of protein-ligand binding free energies.

We have compared the predictions of ligand-binding affinities from several methods based on end-point molecular dynamics simulations and continuum solvation, i.e. methods related to MM/PBSA (molecular mechanics combined with Poisson-Boltzmann and surface area solvation). Two continuum-solvation models were considered, viz. the Poisson-Boltzmann (PB) and generalised Born (GB) approaches. The non-el

On the Structure of Subordinate Clauses in Swedish

This paper presents a novel observation on Swedish subordinate clause structure. I show that in embedded V2 clauses, negation may only precede quantified subjects in the position following the complementizer; this is the very same limitation as found in the first position of main clauses. This correlation I take to provide a strong argument for assuming V-to-C movement in embedded V2 clauses. This

Ethanol production in biorefineries using lignocellulosic feedstock - GHG performance, energy balance and implications of life cycle calculation methodology

Co-production of high-value biobased products in biorefineries is a promising option for optimized utilization of biomass. Lignocellulosic materials such as agricultural and forest residues have been identified as attractive alternative feedstocks because of their high availability and low resource demand. This study assessed the greenhouse gas (GHG) performance and energy balance of ethanol co-pr

Time-resolved investigation of nanometer scale deformations induced by a high flux x-ray beam

We present results of a time-resolved pump-probe experiment where a Si sample was exposed to an intense 15 keV beam and its surface monitored by measuring the wavefront deformation of a reflected optical laser probe beam. By reconstructing and back propagating the wavefront, the deformed surface can be retrieved for each time step. The dynamics of the heat bump, build-up and relaxation, is followe