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Elevated pulse pressure preceded incident chronic kidney disease in the general older population in Sweden

Arterial stiffness (AS) and chronic kidney disease (CKD) are common in the older population. AS results in increased pulsatile pressure, elevated pulse pressure (PP), and is linked to hypertension. PP is a surrogate for AS. The kidney has low vascular resistance mechanisms, presumably making it vulnerable to the increased pulsatile pressure and hypertension associated with AS. The aims of this stu

Investigating Conspiracy Theoires : Introduction to the Special Issue

This introduction to this special issue of Inquiry looks at recent work in the philosophy of conspiracy theory theory. Looking at two related worries expressed in the wider conspiracy theory theory (the academic study of conspiracy theories) – the Problem of Conspiracy Theories and the Problem of Conspiracy Theorists – this special issue argues that recent work in the philosophy of conspiracy theo

Parental Perception of Infants’ use of Mobile Devices: A Qualitative Exploration

Despite the clear restrictive guidelines about the use of modern handheld devices among children younger than 2 years, parents are seen to extensively use these devices with their infants. However, parents’ perceptions in this regard remain unclear and underexplored especially, in the context of South Asian cultures such as Pakistan. This qualitative study aims to explore parents’ perceptions rega

Canaries of Democracy : The Role of Public Libraries in Times of Political Turmoil

This article reports conclusions from a three-year research project on Swedish public libraries. The focus of the project is on librarians experience of libraries mission to promote democracy when democratic norms and values are challenged politically by radical right populism. Results of a longitudinal survey point to stability and lack of political interest over time, but increased societal polaThis article reports conclusions from a three-year research project on Swedish public libraries. The focus of the project is on librarians experience of libraries mission to promote democracy when democratic norms and values are challenged politically by radical right populism. Results of a longitudinal survey point to stability and lack of political interest over time, but increased societal pola

Deciphering the genetics and mechanisms of predisposition to multiple myeloma

Multiple myeloma (MM) is an incurable malignancy of plasma cells. Epidemiological studies indicate a substantial heritable component, but the underlying mechanisms remain unclear. Here, in a genome-wide association study totaling 10,906 cases and 366,221 controls, we identify 35 MM risk loci, 12 of which are novel. Through functional fine-mapping and Mendelian randomization, we uncover two causal

A radically usage-based, collostructional approach to assessing the differences between negative modal contractions and their parent forms

Starting from the premise that English negative modal contractions constitute partly variable patterns of associations that include both the preceding subject and the following verb infinitive, the study sets out to investigate distributional differences between can’t, shouldn’t, and won’t and their corresponding uncontracted parent forms. Given that some configurations are assumed to correlate wiStarting from the premise that English negative modal contractions constitute partly variable patterns of associations that include both the preceding subject and the following verb infinitive, the study sets out to investigate distributional differences between can’t, shouldn’t, and won’t and their corresponding uncontracted parent forms. Given that some configurations are assumed to correlate wi

Frequency information and reduction in second-language perception of multi-word sequences

Entrenchment of multi-word sequences is known to shape native language competence, but there is debate about how (much) it affects L2 speakers. We investigate advanced English learners’ receptive processing of multi-word sequences with a word-monitoring experiment. The effect of reduction on recognition of the word to was tested in English V-to-Vinf constructions of varying surface frequencies and

Exploring the Early Molecular Pathogenesis of Osteoarthritis Using Differential Network Analysis of Human Synovial Fluid

The molecular mechanisms that drive the onset and development of osteoarthritis (OA) remain largely unknown. In this exploratory study, we used a proteomic platform (SOMAscan assay) to measure the relative abundance of more than 6000 proteins in synovial fluid (SF) from knees of human donors with healthy or mildly degenerated tissues, and knees with late-stage OA from patients undergoing knee repl

Prevalence and classification of meniscal calcifications in the human knee

OBJECTIVE: To investigate the occurrence of meniscal calcifications in individuals with and without knee osteoarthritis (OA). Additionally, we aim to identify the specific types of calcifications: basic calcium phosphate (BCP) and calcium pyrophosphate dihydrate (CPP).METHOD: We analysed 82 meniscal posterior horn samples (medial and lateral) collected from 41 human subjects. Among them, 20 indivi

Cold War Conduct : Knowledge Transfer, Psychological Defence, and Media Preparedness in Denmark Between Sweden, Norway, and NATO, 1954–1967

Employing the Foucauldian term ‘conduct’, this article explores how social resilience and morale became a target of state intervention in Denmark during the Cold War. ‘Psychological defence’ was a Cold War phenomenon designed to bring an imagined future war into a space of control as well as a tool for the authorities’ exercise of power in case another world war became a reality. Advocating a methEmploying the Foucauldian term ‘conduct’, this article explores how social resilience and morale became a target of state intervention in Denmark during the Cold War. ‘Psychological defence’ was a Cold War phenomenon designed to bring an imagined future war into a space of control as well as a tool for the authorities’ exercise of power in case another world war became a reality. Advocating a meth

Intervention fidelity and factors affecting the process of implementing a mobile phone text messaging intervention among adolescents living with HIV : A convergent mixed-methods study in southern Ethiopia

Objective To assess the intervention fidelity and explore contextual factors affecting the process of implementing a mobile phone text messaging intervention in improving adherence to and retention in care among adolescents living with HIV, their families and their healthcare providers in southern Ethiopia. Design A convergent mixed-methods design guided by the process evaluation theoretical frame

Water quality for citizen confidence: The implementation process of 2020 EU Drinking Water Directive in Nordic countries

The European Union Drinking Water Directive aims to protect human health and promote safe water consumption. The 2020 revision, Article 17 in particular, directed member states to provide public access to information on drinking water. This update was a response to citizen initiatives calling for the active participation of end-users in water services and greater transparency from water utilities.

Risk Factors for Infection After Transrectal Prostate Biopsy : A Population-based Register Study

BACKGROUND AND OBJECTIVE: Infection after transrectal prostate biopsy (TPBx) is a well-known risk. A comprehensive investigation of risk factors may identify measures for safe TPBx as an alternative to a change in biopsy route. The aim of this study was to identify risk factors for infection after TPBx.METHODS: We included all outpatient TPBx cases in Region Kronoberg, Sweden, from January 2010 to

Nucleotide binding to the ATP-cone in anaerobic ribonucleotide reductases allosterically regulates activity by modulating substrate binding

A small, nucleotide-binding domain, the ATP-cone, is found at the N-terminus of most ribonucleotide reductase (RNR) catalytic subunits. By binding adenosine triphosphate (ATP) or deoxyadenosine triphosphate (dATP) it regulates the enzyme activity of all classes of RNR. Functional and structural work on aerobic RNRs has revealed a plethora of ways in which dATP inhibits activity by inducing oligome

Play biotopes put into practice - Creating synergies between children and nature

1. Global urbanisation reduces greenery and species richness (biodiversity) and limits opportunities for most children to gain experiences of nature. Disconnecting children from nature has implications for their play, health, well-being, and comprehension of ecological systems, as well as their engagement with the environment as adults.2. In the competition for land for built infrastructure, the pGlobal urbanisation reduces greenery and species richness (biodiversity) and limits opportunities for most children to gain experiences of nature. Disconnecting children from nature has implications for their play, health, well-being, and comprehension of ecological systems, as well as their engagement with the environment as adults.In the competition for land for built infrastructure, the preserv

Children's time allocation and the socioeconomic gap in human capital

Children's time investments in various activities may be important for reducing socioeconomic status (SES) gaps in educational and mental health outcomes. Using detailed time use diaries of Australian children aged 4–14, we observe that children from low SES backgrounds spend more time on digital media and less time on out-of-school enrichment activities, organised or for leisure. We explain the S

Assessing the Combined Risk of Fire and Flood on a National Scale for Sweden

Floods and wildfires are two critical hazards that impose substantial direct and indirect costs to society, including the resource needs of rescue services. Their occurrence is strongly linked to meteorological conditions, playing a fundamental role in hazard development and assessment. These hazards are notably distinguishable due to opposing weather requirements, wet conditions for floods and dr