Characterization of DAT missense mutations in novel mouse models
The dopamine transporter (DAT) is responsible for dopamine (DA) clearance in the synaptic cleft, and thus crucial for maintaining DA homeostasis in the central nervous system (CNS). Mutations in the DAT coding gene have been associated with both movement and psychiatric disorders, such as parkinsonism and attention-deficit hyperactivity disorder (ADHD). However, the detailed contribution of DAT in