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Incidence of bullous pemphigoid in Sweden 2005–2012 : a nationwide population-based cohort study of 3761 patients

Studies that report the incidence of bullous pemphigoid from validated nationwide population-based registries are rare. The aim of this study was to estimate the incidence of bullous pemphigoid in Sweden 2005–2012. A population-based open cohort study was designed including all patients diagnosed by a dermatologist with bullous pemphigoid (BP) in Sweden from 2005 to 2012 (n = 3761), identified fro

A phylogenetic view of the Out of Asia/Eurasia and Out of Africa hypotheses in the light of recent molecular and palaeontological finds

The substantiality of the Out of Africa hypothesis was addressed in the light of recent genomic analysis of extant humans (Homo sapiens sapiens, Hss) and progress in Neanderthal palaeontology. The examination lent no support to the commonly assumed Out of Africa scenario but favoured instead a Eurasian divergence between Neanderthals and Hss (the Askur/Embla hypothesis) and an Out of Asia/Eurasia

‘Youth-friendly’ characteristics of professionals in mental health settings

Adolescents have a unique developmental vulnerability to suicide, with youth presenting as the second most vulnerable group to suicide across the lifespan. Youth have been recognized as underserved mental health service recipients, with only one in six of those in need receiving care. Calls for innovative mental health services to better serve youth have been articulated for over a decade and the

Will Science and Technology Solve China’s Unemployment Problem?

China needs a substantial growth of modern-sector employment to absorb its huge supply of underemployed people and new labor market entrants. The present crisis with its massive layoffs of workers makes the issue even more pressing. Although the government has announced large public investments to deal with the business cycle downturn, less attention has been paid to the structural aspects of Chin

Searches for transverse momentum dependent flow vector fluctuations in Pb-Pb and p-Pb collisions at the LHC

The measurement of azimuthal correlations of charged particles is presented for Pb-Pb collisions at sNN=2.76 TeV and p-Pb collisions at sNN=5.02 TeV with the ALICE detector at the CERN Large Hadron Collider. These correlations are measured for the second, third and fourth order flow vector in the pseudorapidity region |η| < 0.8 as a function of centrality and transverse momentum pT using two obser

Population Growth and Job Creation in Timor-Leste

Timor-Leste began its independence as one of the poorest nations in the world. Substantial progress has been made thereafter but the challenges for future development are numerous. High population growth and modest growth of GDP means that per capita income is declining and that the extent of poverty is increasing. For this situation to change, income opportunities other than those provided by sub

Foreign Firms and Chinese Employment

This paper examines the effect of foreign direct investment (FDI) on employment in the Chinese manufacturing sector. As one of the world's largest recipients of FDI, China has arguably benefited from foreign multinational enterprises in various respects. However, one of the main challenges for China, and other developing countries, is job creation, and the effect of FDI on employment is uncertain.

Foreign Networks and Exports : Results from Indonesian Panel Data

Most firms and plants in developing countries produce only for the domestic market and few are able to export. One plausible hypothesis is that foreign networks decrease export costs and that plants with large amounts of such networks will be relatively likely to start exporting. We focus on two types of foreign networks: foreign ownership and imports of intermediate products. Our results suggest

Treatment with the WNT5A-mimicking peptide Foxy-5 effectively reduces the metastatic spread of WNT5A-low prostate cancer cells in an orthotopic mouse model

Prostate cancer patients with high WNT5A expression in their tumors have been shown to have more favorable prognosis than those with low WNT5A expression. This suggests that reconstitution of Wnt5a in low WNT5A-expressing tumors might be an attractive therapeutic approach. To explore this idea, we have in the present study used Foxy-5, a WNT5A mimicking peptide, to investigate its impact on primar

Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis

Background: Glycated hemoglobin (HbA1c) is used to diagnose type 2 diabetes (T2D) and assess glycemic control in patients with diabetes. Previous genome-wide association studies (GWAS) have identified 18 HbA1c-associated genetic variants. These variants proved to be classifiable by their likely biological action as erythrocytic (also associated with erythrocyte traits) or glycemic (associated with

Age does not affect the outcome after digital nerve repair in children – A retrospective long term follow up

Background Digital nerve injuries in children are not common, but they are considered to have an excellent prognosis, compared to adults, after nerve injury and repair. In studies including both children and adults age have been found to have an effect on outcome after nerve repair. Methods We investigated in a retrospective follow up study the long-time result after digital nerve injury and repai

The Duty of Mutual Trust in EU Law and the Duty to Secure Human Rights : Can the EU's Accession to the ECHR Ease the Tension?

The principle of mutual trust has been a central pillar of the European integration project, first as a tool for market integration, and as the European Economic Community became the European Union, as a mechanism for a more wide ranging integration of the legal orders of the member states. The EU now has legislation in place which imposes obligations on member states to trust each other's civil a

Material selection - A qualitative case study of five design consultancies

This qualitative case study aims at understanding when and how industrial designers, working in design consultancies, engage in activities that will influence material selection in the design process. While the extant literature presents material selection processes as a sequence of activities aimed at finding candidate materials, there is paucity of research on material criteria activities. Formu

The language of freedom and slavery in tacitus agricola

The Agricola has long been a popular object of study for the connection that it makes between the British narrative of resistance against Roman domination and the Roman narrative of resistance against imperial domination. However, no agreement has been reached on the question of how exactly the two narratives 'affect' each other. Simultaneously, while it has often been remarked that Tacitus' langu

Investigation of the Effect of Grinding Parameters on Surface Quality in Grinding of TC4 Titanium Alloy

In order to improve the surface quality of TC4 titanium alloy parts, the effect of grinding parameters on surface integrity must be known. In this research, an experimental analysis has been conducted to understand the effect of grinding parameters, including cutting velocity, feed rate, grinding depth and abrasive size, on material removal and surface integrity. Before conducting experiment, test

An experimental study of effects of confinement ratio on swirl stabilized flame macrostructures

Swirl stabilized premixed flames are common in industrial gas turbines. The flame shape in the combustor is highly related to the combustion stability and the performance of the gas turbine. In the current paper, the effects of confinement on the time averaged flame structures or flame macrostructures are studied experimentally. Experiments are carried out with swirl number S = 0.66 in two cylindr

Nanoenvironmental Effects Dramatically Influence the Sensitivity of Immunoassays

It is possible to improve the sensitivity of immunoassays by several orders of magnitude by exploiting nanoenvironmental effects. This approach can detect trace amounts of compounds and will better illuminate the presence of signal substances in biological systems. Here we describe a method for ultrasensitive immunoassays using 'normal' antibodies (Abs).

Diesel soot aging in urban plumes within hours under cold dark and humid conditions

Fresh and aged diesel soot particles have different impacts on climate and human health. Whilefresh diesel soot particles are highly aspherical and non-hygroscopic, aged particles are sphericaland hygroscopic. Aging and its effect on water uptake also controls the dispersion of diesel soot inthe atmosphere. Understanding the timescales on which diesel soot ages in the atmosphere is thus important,Fresh and aged diesel soot particles have different impacts on climate and human health. While fresh diesel soot particles are highly aspherical and non-hygroscopic, aged particles are spherical and hygroscopic. Aging and its effect on water uptake also controls the dispersion of diesel soot in the atmosphere. Understanding the timescales on which diesel soot ages in the atmosphere is thus importa