Objectives Physical inactivity and sedentary behaviour are associated with higher breast cancer risk in observational studies, but ascribing causality is difficult. Mendelian randomisation (MR) assesses causality by simulating randomised trial groups using genotype. We assessed whether lifelong physical activity or sedentary time, assessed using genotype, may be causally associated with breast can

This special issue of the AJCH celebrates the life and work of Professor Irving Kirsch (Figure 1; my gratitude to the contributors, to Journal Editor-in-Chief, Stephen R. Lankton, and to Irving Kirsch, who provided me with information and photographs). I decided to organize this tribute not only because Professor Kirsch has been a towering figure in hypnosis and related areas, but because he has b

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and m

An enhanced flamelet generated manifold (FGM) model for large eddy simulation (LES) of turbulent spray combustion is presented. In the enhanced FGM model, a transported probability density function (TPDF) description of the FGM variables is employed. The TPDF is represented using the Eulerian stochastic fields (ESF) approach, and the method is applied to LES of spray combustion under conditions re

The frst May Measurement Month (MMM) campaign, a global blood pressure (BP) screening programme, began in 2017 as an initiative of the International Society of Hypertension.1 Two subsequent annual campaigns have also been completed in consecutive years2,3 and having had to defer activities due to the COVID-19 pandemic in 2020 the fourth campaign was run in 2021, the results of which are currently

Uppsatsen ämnar klargöra när patienter inom psykiatrisk tvångsvård lagligen kan delta i medicinsk forskning om psykiatrisk tvångsvård. En patient inom psykiatrisk tvångsvård kan nämligen vara förhindrad att lämna giltigt samtycke till deltagande i forskning mot bakgrund av sitt psykiska tillstånd och att den kan känna sig tvingad att delta då den befinner sig inom tvångsvården. I lagen (2003:460) This essay aims at clarifying when patients in compulsory psychiatric care can be included in medical research projects concerning compulsory psychiatric care. A patient in compulsory psychiatric care could be unable to provide valid consent to participate in research due to their mental state and the fact that they can feel obliged to consent since they are in compulsory care. The Ethical Review

Framtidens digitalisering av tumöranalyser för bättre behandling och prognos Läkarkonsten är på väg att få fler redskap för att individanpassa cancerbehandlingar och få en bättre patientöverlevnad. Intressant nog kan vi i framtiden komma till att förutsäga tumörers svar på behandling utifrån en matematisk algoritm som med hjälp av uppmätta gen- och proteinnivåer skattar halten av olika immuncelleIntroduction: There is a shortcoming in current breast cancer treatment, where some patients get overtreated leading to unnecessary side effects and others will not respond to the indicated treatment. Immune infiltration appears to have potential to become an important parameter when predicting how the tumour will respond to certain treatments, prognosing the survival rates in different subgroups

Punctuality is a key factor in railway operations and is affected by both primary and secondary delays to differing degrees. Being able to separate these two types of delays is very important when simulating operations, and when conducting punctuality improvement efforts. However, it is not easy to estimate the relative proportions of primary versus secondary delays using historical data. In this

I Sverige är befolkningen mån om att köpa second hand, återvinna, sortera sopor, äta vegetariskt och så vidare. När det däremot gäller den politiska sfären finns det ett Miljöparti som kämpar för att hålla sig ovan riksdagens 4% spärr. Syftet med uppsatsen är att undersöka varför Miljöpartiet har svårt att driva miljöfrågan i den politiska sfären trots goda förutsättningar. Med utgångspunkt i Nikl

Newly qualified social workers (NQSW) in Sweden are often thrust into statutory social work. In the context of statutory social work, social workers need to navigate a professional rationale, on which the social work profession rests, with an organizational rationale, on which the welfare organization – the social services – rests. This is due to the fact that social workers often are reliant on w

The development and expansion of artificial intelligence have significant potential to benefit humanity; however, the risks posed by AI-related tools have also become a growing concern over the past decade. From the standpoint of human rights violations AI-related bias, discriminatory practices, data protection practices and violations or potential infringements on fundamental rights are some of t

The unsustainable work environment of social workers in Swedish social services has been highlighted frequently through various reports. According to various reports, first-line managers in social services seem to play an important role in how to approach an unsustainable work environment. The aim of this study was to analyze how first-line managers in Swedish child social services reflect on soci

The honeybee gut microbiome is thought to be important for bee health, but the role of the individual members is poorly understood. Here, we present closed genomes and associated mobilomes of 102 Apilactobacillus kunkeei isolates obtained from the honey crop (foregut) of honeybees sampled from beehives in Helsingborg in the south of Sweden and from the islands Gotland and Åland in the Baltic Sea.

Lakes are important natural resources and carbon gas emitters and are undergoing rapid changes worldwide in response to climate change and human activities. A detailed global characterization of lakes and their long-term dynamics does not exist, which is however crucial for evaluating the associated impacts on water availability and carbon emissions. Here, we map 3.4 million lakes on a global scal

Jet impingement cooling is an effective way for thermal management in electronics, prevailed over many other single heat transfer modes. In general, jet arrays are better than a single jet, enhancing jet cooling performance. However, the performance of jet arrays is strongly dependent on the jet configurations, e.g., adjacent jet interval and hole-to-surface distance. Thus, in this study, jet impi

As the number of antennas scales up, research efforts have been directed towards finding decentralized receiver solutions for multi-antenna architectures. In a recent paper, a novel matrix decomposition - the WAX decomposition - was proposed, which has direct bearing on characterizing the level of decentralization that is possible if the complexity of the decentralized processing is limited. Howev