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Background: Transcatheter aortic valve implantation (TAVI) has become a safe procedure. However, complications occur, including uncommon complications such as valve malposition, which requires the implantation of an additional rescue valve (rescue-AV). The aim was to study the occurrence and outcomes of rescue-AV in a nationwide registry. Methods: The Swedish national TAVI registry was used as the

Expectations and demands on coproduction in research have increased. Therefore, there is a need for knowledge on how these coproducing processes where researchers and practitioners work side by side during the research process can be carried out. In this article, methodological questions related to coproduction and collaboration between researchers and practitioners in the field of social work are

DEBATE. We researchers have long demanded that the government take climate research seriously and speed up the transition to a sustainable society.Instead, the government is pursuing a policy that deliberately increases emissions. Now more citizens need to raise their voices and show that we demand a knowledge-based climate transition, and it is urgent.

The digital transformation is rapidly changing in-store service settings. This paper explores how frontline employees experience and cope with technology-related challenges. Based on a qualitative approach and the use of observations and interviews, this research advances our understanding of how such coping is performed in retail stores and how it contributes to defining employees’ work experienc

Förebyggande av oönskade graviditeter och sexuellt överförbara infektioner (vad jag kallar "contracepting") behandlas ofta som ett medicinskt eller hälsovårds- problem snarare än en social fråga. Till följd av detta, förblir mycket av det vardagliga arbetet som preventivmetoder innefattar osynligt. Unga människor i synnerlighet talas oftare om än med när det kommer till deras användning av preventContraception is a complex phenomenon with differing meanings, expressions, and materialities depending on its historical, social, and cultural context. In this thesis, I depart from the conceptualisation of contraception as the prevention of both pregnancies and sexually transmitted infections (STIs) and I name these practices through the collective term of contracepting. Previous research on you

Empowering Children and Youththrough Law and ParticipationIn 2023, between August the 30th and September the 1st, the Child RightsInstitute at the Department of Sociology of Law, within Faculty of SocialSciences, Lund University, was arranging a three-day research conference onthe theme Empowering Children and Youth through Law and Participation.41 participants from 13 different countries particip

Introduction: Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease affecting multiple organs in the human body, including the central nervous system. Recently, an artificial intelligence method called BrainAGE (Brain Age Gap Estimation), defined as predicted age minus chronological age, has been developed to measure the deviation of brain aging from a healthy population us

Classifying active galactic nuclei (AGNs) is a challenge, especially for BL Lacertae objects (BLLs), which are identified by their weak emission line spectra. To address the problem of classification, we use data from the fourth Fermi Catalog, Data Release 3. Missing data hinder the use of machine learning to classify AGNs. A previous paper found that Multivariate Imputation by Chain Equations (MI

The upper layer of our skin, the stratum corneum (SC), is a versatile material that combines mechanical strength with efficient barrier function. In this paper, we discuss these macroscopic properties of SC in relation to recent findings on molecular responses and structural diversity in SC protein and lipids. We put particular focus on the intermediate (colloidal) length scale and how the differe

The ECG diagnosis of LVH is predominantly based on the QRS voltage criteria, i.e. the increased QRS complex amplitude in defined leads. The classical ECG diagnostic paradigm postulates that the increased left ventricular mass generates a stronger electrical field, increasing the leftward and posterior QRS forces. These increased forces are reflected in the augmented QRS amplitude in the correspond

BACKGROUND: Small-cell lung cancer (SCLC) molecular subtypes have been primarily characterized based on the expression pattern of the following key transcription regulators: ASCL1 (SCLC-A), NEUROD1 (SCLC-N), POU2F3 (SCLC-P) and YAP1 (SCLC-Y). Here, we investigated the proteomic landscape of these molecular subsets with the aim to identify novel subtype-specific proteins of diagnostic and therapeut

BACKGROUND: Patients with kidney failure have a high risk for cardiovascular events. We aimed to evaluate the prognostic importance of selected biomarkers related to haemostasis, endothelial function, and vascular regulation in patients with acute coronary syndrome (ACS), and to study whether this association differed in patients with renal dysfunction.METHODS: Plasma was collected in 1370 ACS pat

PURPOSE: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC.EXPERIMENTAL DESIGN: The efficacy of HDACi

Residual problems may occur from neuroma despite surgery. In a 12-month follow-up study using national register data, symptoms, and disabilities related to surgical methods and sex were evaluated in patients surgically treated for a neuroma. Among 196 identified patients (55% men; lower age; preoperative response rate 20%), neurolysis for nerve tethering/scar formation was the most used surgical m

Recent advances have shown that sound fields can be accurately interpolated between microphone measurements when the spatial covariance matrix is known. This matrix may be estimated in various ways; one promising approach is to use a plane wave formulation with sparse priors, although this may require the use of a many microphones to suppress the noise. To overcome this, we introduce a time domain

Background: The immunogenicity, safety, and efficacy of recombinant factor VIII (rFVIII) have gained increasing interest after the introduction of extended half-life products with various modifications of the rFVIII molecule, such as covalent attachment of polyethylene glycol (PEG). Anti-PEG antibodies may be associated with a temporary reduction of FVIII recovery, but according to previous studie

In this conceptual article, we argue that artificial intelligence (AI) systems are contributing to the generation of an environment of affordances for everyday information practices through which they exert influence on people and the planet in ways that often are left unrecognised. We illustrate our insights by focusing on the practices of information seeking in everyday life, suggesting that the

A method that could assess the whole vehicle non-exhaust particle (NEP) emission from the whole vehicle level was proposed by combining sealed housing with the chassis dynamometer. The intake and exhaust systems were connected to the out of the chamber to avoid possible effects on NEP emissions. The most distinguishing feature of the proposed method is the whole vehicle assessment of the NEP. Base

Segregated bimetallic nanoparticles like core-shell nanoparticles are of interest in various fields including biomedicine, catalysis, and optoelectronics. Aerosol technology is an optimal platform to control nanoparticle size, structure, and composition, which are some of the most important parameters tuning the material performance for the intended applications. Here, we develop a novel evaporato