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Adapting the Sustainable Development Goals and the New Urban Agenda to the city level: Initial reflections from a comparative research project

The Sustainable Development Goals and the New Urban Agenda recognise the roleof cities in achieving sustainable development. However, these agendas wereagreed and signed by national governments and thus implementing them at thelocal level requires a process of adaptation or localisation. In this paper, we analyse five aspects that practitioners and researchers need to consider when localising them

Reconstructing the Evolution of Indo-European Grammar

This study uses phylogenetic methods adopted from computational biology in order to reconstruct features of Proto-Indo-European morphosyntax. We estimate the probability of the presence of typological features in Proto-Indo-European on the assumption that these features change according to a stochastic process governed by evolutionary transition rates between them. We compare these probabilities t

Evolutionary dynamics of Indo-European alignment patterns

This paper employs phylogenetic modeling to reconstruct the alignment system of Indo-European. We use a data set of categorical morphosyntactic features, which take states such as ‘nominative-accusative’, ‘active-stative’, or ‘ergative’. We analyze these characters with a standard Bayesian comparative phylogenetic method, inferring transition rates between character states on the basis of a phylog

Genome-wide association study of cerebral small vessel disease reveals established and novel loci

Intracerebral haemorrhage and small vessel ischaemic stroke (SVS) are the most acute manifestations of cerebral small vessel disease, with no established preventive approaches beyond hypertension management. Combined genome-wide association study (GWAS) of these two correlated diseases may improve statistical power to detect novel genetic factors for cerebral small vessel disease, elucidating unde

Mental health provision in schools: approaches and interventions in 10 European countries

Background.The role of schools in providing community-based support for children's mental health and well-being is widely accepted and encouraged. Research has mainly focused on designing and evaluating specific interventions and there is little data available regarding what provision is available, the focus and priorities of schools and the professionals involved in providing this support. The cu

Examining Mental Health and Well-being Provision in Schools in Europe: Methodological Approach

Schools are considered an ideal setting for community-based mental health and well-being interventions for young people. However, in spite of extensive literature examining the effectiveness of such interventions, very few studies have investigated existing mental health and well-being provision in schools. The current study aims to extend such previous research by surveying primary and secondary

Hospital accreditation, reimbursement and case mix : Links and insights for contractual systems

Background: Resource consumption is a widely used proxy for severity of illness, and is often measured through a case-mix index (CMI) based on Diagnosis Related Groups (DRGs), which is commonly linked to payment. For countries that do not have DRGs it has been suggested to use CMIs derived from International Classification of Diseases (ICD). Our research objective was to use ICD-derived case-mix t

Accumulated neighbourhood deprivation and coronary heart disease : A nationwide cohort study from Sweden

Objective Neighbourhood deprivation is a recognised predictor of coronary heart disease (CHD). The overall aim was to investigate if accumulated exposure to neighbourhood deprivation resulted in higher odds of CHD. Design This is a longitudinal cohort study. Models based on repeated assessments of neighbourhood deprivation as well as single-point-in-time assessments were compared. Setting Sweden.

Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer's and Parkinson's disease

Background: Increasing evidence implicates dysfunctional proteostasis and the involvement of the autophagic and endo-lysosomal system and the ubiquitin-proteasome system in neurodegenerative diseases. In Alzheimer's disease (AD), there is an accumulation of autophagic vacuoles within the neurons. In Parkinson's disease (PD), susceptibility has been linked to genes encoding proteins involved in aut

Highlighting the Dynamics of Graphene Protection toward the Oxidation of Copper under Operando Conditions

We performed spatially resolved near-ambient-pressure photoemission spectromicroscopy on graphene-coated copper in operando under oxidation conditions in an oxygen atmosphere (0.1 mbar). We investigated regions with bare copper and areas covered with mono- and bi-layer graphene flakes, in isobaric and isothermal experiments. The key method in this work is the combination of spatial and chemical re