Group A Streptococcus (GAS) is a human-specific bacterial pathogen that can exploit the plasminogen-plasmin fibrinolysis system to dismantle blood clots and facilitate its spread and survival within the human host. In this study, we use affinity-enrichment mass spectrometry to decipher the host-pathogen protein-protein interaction between plasminogen and streptolysin O, a key cytolytic toxin produ

This paper concerns control of a class of systems where multiple dynamically stable agents share a nonlinear and bounded control-interconnection. The agents are subject to a disturbance which is too large to reject with the available control action, making it impossible to stabilize all agents in their desired states. In this nonlinear setting, we consider two different anti-windup equipped propor

The concept of strategic communication represents a significant shift from that of corporate communication and, as several scholars have argued (Hallahan et al., 2007; Vercic and Zerfass, 2017), represents a new paradigm useful for interpreting the broadening content of communication and the evolving role it plays in complex organizations. Role which becomes strategic as it increasingly tends to s

Objective: Vaginal hysterectomy combined with uterosacral suspension (USLS) is a technique for treating pelvic organ prolapse. Vaginal natural orifice transluminal endoscopic surgery (vNOTES) has been described as an alternative minimal invasive approachfor treating various gynecological and non-gynecological pathologies. The aim was to compare the surgical time between conventional vaginal hyster

Context. The spectra of fast-rotating A-type stars have strongly broadened absorption lines. This effect causes blending of the absorption lines, hindering the measurement of the abundances of the elements that are in the stellar photosphere.Aims. As the exoplanet transits across its host star, it obscures the stellar spectrum that is emitted from directly behind the planet. We aim to extract this

Context. Ultra-hot Jupiters (UHJ) have emerged as ideal testbeds for new techniques for studying exoplanet atmospheres. Only a limited number of them are currently well studied, however.Aims. We search for atmospheric constituents for the UHJ WASP-178 b with two ESPRESSO transits. Additionally, we show parallel photometry that we used to obtain updated and precise stellar, planetary, and orbital p

Background and Aim: Full-thickness biopsies of the intestinal wall may be used to study and assess damage to the neurons of the enteric nervous system (ENS), that is, enteric neuropathy. The ENS is difficult to examine due to its localization deep in the intestinal wall and its organization with several connections in diverging directions. Histological sections used in clinical practice only visua

We construct tradable risk factors using combinations of large and liquid mutual funds (long leg) and ETFs (exchange-traded funds) (long and short legs), based on their holdings, for both retail and institutional investors. Exploiting a novel dataset, our tradable factors take into account ETF shorting costs. Assessing the performance of our tradable factors against standard “on-paper” factors, weWe construct tradable risk factors using combinations of large and liquid mutual funds (long leg) and ETFs (exchange-traded funds) (long and short legs), based on their holdings, for both retail and institutional investors. Exploiting a novel dataset, our tradable factors take into account ETF shorting costs. Assessing the performance of our tradable factors against standard “on-paper” factors, we

Therapies against cell-surface targets (CSTs) represent an emerging treatment class in solid malignancies. However, high-throughput investigations of CST expression across cancer types have been reliant on data sets of mostly primary tumors, despite therapeutic use most commonly in metastatic disease. We identified a total of 818 clinical trials of CST therapies with 78 CSTs. We assembled a data s

Purpose: The purpose of this study is to contribute to an expansion of what can be considered as a brand. Specifically, this paper examines how streaming series can be seen as brands through a brand identity lens. Methodology: A qualitative research approach, with a social constructivist perspective, has been done by applying the Brand Identity Prism, with the additional element brand promise, to

BackgroundIn 2015, a selective decrease in the glomerular filtration of middle-sized molecules such as cystatin C compared to small molecules such as creatinine was first described and tentatively termed “Shrunken pore syndrome.” Numerous studies have thereafter found an association between this syndrome (defined by a low eGFRcystatin C to eGFRcreatinine ratio) and mortality and morbidity. In 2023

BACKGROUND: Physical function constitutes a key component of outcome assessment for almost all osteoarthritis interventions. The aim was to compare physical function measured using a self-assessed performance-based test versus self-reported function using questionnaires among individuals with knee or hip osteoarthritis (OA) participating in a digital exercise and education therapy.METHODS: We anal

Previous research has shown that the two languages of early bilingual children can influence each other, depending on the linguistic property, while adult bilinguals predominantly show influence from the majority language to the minority (heritage) language. While this observed shift in influence patterns is probably related to a shift in dominance between early childhood and adulthood, there is l

Objectives: Vibration exposure is a known risk factor for developing carpal tunnel syndrome (CTS), and insufficient outcomes for surgery for CTS have been reported after such exposure. We aim to investigate whether vibration exposure affects patient-reported outcomes following open carpal tunnel release. Methods: From a population surgically treated for CTS (n = 962), we identified patients who re

We investigate German–Russian bilingual children's sensitivity to formal and semantic cues when assigning gender to nouns in German. Across languages, young children have been shown to primarily rely on phonological cues, whereas sensitivity to semantic and syntactic cues increases with age. With its semi-transparent gender assignment system, where both formal and semantic cues are psycho linguist

Background: Regardless of the indisputable benefits of insulin therapy, initiating insulin for newly diagnosed type-1 children with diabetes might be intimidating for parents. This study assesses the experience, fears, barriers and adherence to insulin use among the parents of early-diagnosed children with diabetes. Methods: A cross-sectional online survey was utilized for data collection from 218