OBJECTIVE: Glucocorticoid-induced tumor necrosis factor receptor family-related protein (GITR) is expressed on CD4(+) effector memory T cells and regulatory T cells; however, its role on these functionally opposing cell types in atherosclerosis is not fully understood.APPROACH AND RESULTS: Low-density lipoprotein receptor-deficient mice (Ldlr(-/-)) were lethally irradiated and reconstituted with e

BACKGROUND AND AIMS: Atherosclerosis is a lipid-driven chronic inflammatory disorder of the arteries, and monocytes and macrophages play a central role in this process. Within the atherosclerotic lesion, macrophages can scavenge modified lipids and become the so-called foam cells. We previously reported that the epigenetic enzyme Kdm6b (also known as Jmjd3) controls the pro-fibrotic transcriptiona

Social workers strive to provide the best support to each client, making it crucial to consider not just group-level effects of interventions but also individual outcomes. While empirical evidence often stems from group-based analyses, these offer limited insights into individual change, which is key for tailoring interventions. The aim of this study is to highlight the importance of individual-le

Introduction: During recent years, the world—including Scandinavia—has experienced significant challenges with shortages of antibiotics. In Scandinavia, phenoxymethylpenicillin is recommended as first-line antibiotic treatment for most acute respiratory tract infections (ARTIs). However, the Scandinavian countries each constitute rather small markets for phenoxymethylpenicillin. The aim of this di

У цій статті досліджено професійний підхід до ілюстрування книг для дітей та підлітків. Також визначено значення розвитку фантазії, образного мислення, виховання смаку та введення у світ сучасного мистецтва. Описано принципи оформлення та ілюстрування книг з урахуванням вікових особливостей сприйняття дітей, а також важливість привабливості ілюстрацій для зацікавлення маленьких читачів. РозглянутоThe purpose of the study is to investigate the possibilities of replacing the introductory version of MATLAB in educational disciplines related to digital image processing with an open and free analogue of GNU Octave. Using the example of laboratory tasks for the educational discipline "Digital Image Processing", similar capabilities, functionality and syntax of both software packages have been ex

У цій статті досліджено професійний підхід до ілюстрування книг для дітей та підлітків. Також визначено начення розвитку фантазії, образного мислення, виховання смаку та введення у світ сучасного мистецтва. писано принципи оформлення та ілюстрування книг з урахуванням вікових особливостей сприйняття дітей, а також важливість привабливості ілюстрацій для зацікавлення маленьких читачів. Розглянуто Based on the minimum angular size of the image, which is limited by the resolution of the human visual analyzer, a formula was derived for calculating the diagonal of the screen of the information display device. For two levels of unmanned aircraft systems – operational and tactical – the parameters of video monitors were obtained, which allow improving the image contrast, facilitating the operato

This open access handbook aims to constitute a reference point on political norm dynamics in Southeast Asia, by bringing together the array of normative repertoires that frame the possibilities for citizens to participate in, set agendas for, make decisions in, and contest, not only electoral and institutional politics but also informal and imaginary political spaces. It sheds light on intersectin

In this interview, Prince Sisowath Thomico, a cousin of Cambodian King Sihamoni who has been politically active in a range of political movements and parties, discusses the role of the monarchy and what royalism might mean in Cambodia today, three decades after the Cambodian monarchy was reintroduced. He reflects on the historical trajectory of the Cambodian monarchy and royalism, and analyses how

Background: Immigrant women in Sweden face unique challenges in accessing sexual and reproductivehealth and rights (SRHR ) services, particularly in contraceptive counselling. Despite a well-establishedsystem led by midwives, barriers related to cultural sensitivity, health literacy, and the healthcaresystem's adaptability to diverse needs persist. Understanding immigrant women's perspectives on S

Bias-based bullying (i.e., bullying due to marginalized identities) is a significant and ongoing challenge within contemporaryeducational settings. Teachers are crucial in mitigating such harmful behaviors and cultivating positive peer relationships. Thepresent study explores teachers’ perceptions of and intervention intentions in bias-based bullying situations across diversecultural and education

Protein maldigestion and malabsorption lead to malnutrition and are a feature of exocrine pancreatic insufficiency (EPI). Although it is the current standard, measurement of nitrogen in stool to assess protease activity is indirect. Up to 80% of hydrolysed proteins appear in blood in the form of peptides, so we developed a method to measure peptide-derived amino acids in plasma as a relevant measu

Massively multidimensional diffusion magnetic resonance imaging combines tensor-valued encoding, oscillating gradients, and diffusion-relaxation correlation to provide multicomponent subvoxel parameters depicting some tissue microstructural features. This method was successfully implemented ex vivo in microimaging systems and clinical conditions with tensor-valued gradient waveform of variable dur

"The Academy of St Martin in the Fields are joined by Håkan Hardenberger who will perform a programme celebrating his history with the orchestra, including Haydn’s Trumpet Concerto and a selection from his album Both Sides Now, both recorded with ASMF."These pieces were performed:Georg Philipp Telemann: Konzert für drei Trompeten, zwei Oboen, Pauken, Streicher und B.c. D-dur TWV 54:D3Wolfgang Amad

The molecular characteristics of the pseudoautosomal region (PAR) of sex chromosomes remain elusive. Despite significant genome-sequencing efforts, the PAR of highly differentiated avian sex chromosomes remains to be identified. Here we use linkage analysis together with whole-genome re-sequencing to uncover the 630-kb PAR of an ecological model species, the collared flycatcher. The PAR contains 2

The biology centered around the TGF-beta type I receptor Activin Receptor-Like Kinase (ALK)1 (encoded by ACVRL1) has been almost exclusively based on its reported endothelial expression pattern since its first functional characterization more than two decades ago. Here, in efforts to better define the therapeutic context in which to use ALK1 inhibitors, we uncover a population of tumor-associated

The key concepts and reference points of International Relations (IR) are informed by a sedentarist worldview anchored on the territorial state. IR’s conception of its subject-matter is thus ‘static’ in both senses of the word: state-centric and immobile. One of the consequences of this sedentarist worldview has been a neglect of the world’s nomads. Defined by their spatial mobility, nomads have b