Introduction: Lichen planus is a relatively common inflammatory condition of the nails, skin, and mucosal surfaces. Oesophageal involvement of lichen planus is thought to be very rare, mainly described in case reports, but is associated with a high risk of oesophageal stenosis as well as squamous cell carcinoma. No evidence-based treatment recommendations exist, with the majority of described trea

In recent years there has been a renewed interest in the basal forebrain cholinergic system as a target for the treatment of cognitive impairments in patients with Parkinson's disease, due in part to the need to explore novel approaches to treat the cognitive symptoms of the disease and in part to the development of more refined imaging tools that have made it possible to monitor the progressive c

Cortical arealization arises during neurodevelopment from the confluence of molecular gradients representing patterned expression of morphogens and transcription factors. However, whether similar gradients are maintained in the adult brain remains unknown. Here, we uncover three axes of topographic variation in gene expression in the adult human brain that specifically capture previously identifie

Despite a strong emphasis that individual support services should be provided according to needs, the Swedish welfare system often use age to organize support. A change in the Social Service Act in 2018 allows municipalities to provide home care for people above a decided age without individual any assessment of needs. Political parties and pensioners’ organizations’ have proposed for the introduc

Istället för att kräva sin rätt har äldre förståelse för personalens stressiga situation och accepterar att inte få sina behov tillgodosedda, skriver Håkan Jönson, Tove Harnett och Glenn Möllergren, forskare vid Socialhögskolan i Lund.Företrädare för Kristdemokraterna i Malmö, Lars Hector, Anna Reimer och Henrik Reimer, kritiserar den så kallade minutstyrningen inom hemtjänsten i staden och förkla

BackgroundThe goal of the Fifth Annual Baylor College of Medicine & DNAnexus Structural Variation Hackathon was to push forward the research on structural variants (SVs) by rapidly developing and deploying open-source software. The event took place in-person and virtually in August 2023, when 49 scientists from 14 countries and 8 U.S. states collaboratively worked on projects to address critic

Introduction: FLASH radiotherapy (RT) has emerged as a promising modality, demonstrating both a normal tissue sparing effect and anticancer efficacy. We have previously reported on the safety and efficacy of single fraction FLASH RT in the treatment of oral tumors in canine cancer patients, showing tumor response but also a risk of radiation-induced severe late adverse effects (osteoradionecrosis)

A generalized approach derived from Bloch's equation of motion of nuclear magnetic moments is presented to model the frequency, magnetic field, spin density, and temperature dependencies in the electromagnetic permeability tensor for materials with magnetic resonances. The resulting tensor model predicts characteristic polarization signatures which can be observed, for example, in Mueller matrix e

Background: Transition from child-centered to adult-centered healthcare is a gradual process that addresses the medical, psychological, and educational needs of young people in the management of their autonomy in making decisions about their health and their future clinical assistance. This transfer is challenging across all chronic diseases but can be particularly arduous in rare neurological con

Deformation mechanisms of crystalline solids has been the subject of research for more than two centuries. The theory of dislocations dominates modern views but still has significant gaps demanding the introduction of additional concepts for the coherent quantitative description of physical phenomena. In this work, we propose a coherent geometric description of motion and deformation in crystallin

Purpose – This research analyzes online consumer reviews and ratings to assess e-retail order fulfillment performance. The study aims to (1) identify consumer journey touchpoints in the order fulfillment process and (2) determine their relative importance for the consumer experience.Design/methodology/approach – Text mining and analytics were employed to examine over 100 m online purchase orders,

Recent observations of high-redshift galaxies (z ≲ 7) reveal that a substantial fraction have turbulent, gas-rich disks with well-ordered rotation and elevated levels of star formation. In some instances, disks show evidence of spiral arms, with bar-like structures. These remarkable observations have encouraged us to explore a new class of dynamically self-consistent models using our agama/Ramses

Tulving’s introduction of episodic memory and the metaphor of mental time travel has immensely enriched our understanding of human cognition. However, his focus on human psychology, with limited consideration of evolutionary perspectives, led to the entrenched notion that mental time travel is uniquely human. We contend that adopting a phylogenetic perspective offers a deeper insight into cognitio

Permafrost regions contain approximately half of the carbon stored in land ecosystems and have warmed at least twice as much as any other biome. This warming has influenced vegetation activity, leading to changes in plant composition, physiology, and biomass storage in aboveground and belowground components, ultimately impacting ecosystem carbon balance. Yet, little is known about the causes and m