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Proteins interacting with the human PDGF (platelet-derived growth factor) b-receptor were isolated using immobilized peptides derived from the receptor C-terminus as a bait. We identified two PDZ domain proteins, namely NHERF (Na+/H+ exchanger regulatory factor, also called EBP50) and NHERF2 (E3KARP, SIP-1, TKA-1), which have been shown previously to associate with the murine PDGF receptor [Maudsl

Seven diterpenoids, isolated due to their ability to inhibit spore germination in the plant pathogenic fungus Magnaporthe grisea, were obtained from cultures of the basidiomycete Coprinus heptenlerus. The structures of the compounds, named heptemerones A-G, were determined with spectroscopic techniques. (c) 2005 Elsevier Ltd. All rights reserved.

Artikeln handlar om arbetet med utställningen Odens öga - mellan människor och makter i det förksristna Norden.

Popular Abstract in Swedish Avhandlingen består av fem fristående uppsatser som utnyttjar tidsserieanalys för studerande av några olika makroekonomiska frågor. I kapitel två, tre och fyra används s.k. vektorautoregressiva (VAR) modeller för att studera privat konsumtionsbeteende i Sverige. Enligt den permanenta inkomst hypotesen väljer individerna sin konsumtion med hänsyn till sin långsiktiga ellAdvances in time series analysis during the last two decades have stimulated research in a number of areas in macroeconomics. This thesis is a compilation of five essays using cointegrated vector autoregressive (VAR) models, unit root tests and regime switching models to investigate the behavior of private consumption, public debt and the real exchange rate. Chapter two explores the empirical evi

The angiogenic mechanism and therapeutic potential of PDGF-CC, a recently discovered member of the VEGF/PDGF superfamily, remain incompletely characterized. Here we report that PDGF-CC mobilized endothelial progenitor cells in ischemic conditions; induced differentiation of bone marrow cells into ECs; and stimulated migration of ECs. Furthermore, PDGF-CC induced the differentiation of bone marrow

We report here the identification of a gene associated with the hyperparathyroidism-jaw tumor (HPT-JT) syndrome. A single locus associated with HPT-JT (HRPT2) was previously mapped to chromosomal region 1q25-q32. We refined this region to a critical interval of 12 cM by genotyping in 26 affected kindreds. Using a positional candidate approach, we identified thirteen different heterozygous, germlin

Background: Serial Analysis of Gene Expression (SAGE) is a functional genomic technique that quantitatively analyzes the cellular transcriptome. The analysis of SAGE libraries relies on the identification of ditags from sequencing files; however, the software used to examine SAGE libraries cannot distinguish between authentic versus false ditags ("quasi-ditags"). Results: We provide examples of qu

Little is known concerning possible hazards of maternal use of the recently introduced antidepressant drugs with noradrenergic and varying serotonergic activity (serotonin-noradrenaline reuptake inhibitor [SNRI]/noradrenergic reuptake inhibitor [NRI] drugs). Using the Swedish Medical Birth Registry, we identified 732 women who had used SNRI/NRI drugs in early pregnancy. Maternal characteristics we

In this letter, we present a decomposition for sinusoidal coding of audio, based on an amplitude modulation of sinusoids via a linear combination of arbitrary basis vectors. The proposed method, which incorporates a perceptual distortion measure, is based on a relaxation of a nonlinear least-squares minimization. Rate-distortion curves and listening tests show that, compared to a constant-amplitud

Popular Abstract in Swedish Akut faryngotonsillit orsakas till ca 40 % av betahaemolytiska grupp A streptokocker (GAS) och till ca 10% av andra bakterier. Ca 30% av fallen är virusutlösta och i ca 20% är genesen okänd. GAS är mycket virulenta humanpatogener som förutom svalg- och hudinfektioner även kan förorsaka livshotande tillstånd som ?streptococcal toxic shock syndrome? och nekrotiserande fasIn acute pharyngotonsillitis group A streptococci (GAS) is the etiological agent in 30-50% of cases. Phenoxymethylpenicillin (pcV) is the drug of choice in Sweden. However, the failure rate is as high as 5-25% and further pcV treatment is followed by still higher failure rates. The background of failures remains largely elusive. The aim of the studies was: 1 To investigate the short- and long-term

Medieval watermills: A review of Christian Fischers monograph “Tidlige danske vandmøller. To middelalderlige vandmøller ved Tovstrup og Vejerslev” (Early Danish Watermills. Two medieval watermills at Tovstrup and Vejerslev) from 2004.

To study the absorption, metabolism and kinetics, the AKG ( in different concentrations) was administered intravenously, intra-portally, orally and directly into the ileum or duodenum of pigs, chronically fitted with portal and jugular catheters and T-shaped cannula at the duodenum and ileum. Additionally, this study was conducted to determine the influence of low pH, Fe2+ or/ and SO42- on AKG gut

Microcalorimetry, i.e., the measurement of heat production rate was used to assess the metabolic activity of six wood-decay fungi growing on moist wood particles as a function of the temperature. Four brown-rot fungi increased their activity with increasing temperature in the temperature range 5-35 C, and one brown-rot and the white-rot fungus had a lower activity at 35 C than at 25 C. It may be p

On the basis of a neurolinguistic assessment procedure (Holmberg and Sahlen, 1986) ten children with severe and specific developmental language disorders (DLD) were studied over a four-year period. Initially they all showed global language problems which, in the course of development, became more specific. Although there were considerable differences in the neurolinguistic profiles, some general p

This report presents a detailed description of the phenomena flashover, backdraft and smoke gas explosion. The physical and chemical processes which are involved in these phenomena are thoroughly discussed. The report also describes a number of compartment fire scenarios which are believed to be the most common scenarios occurring in Sweden. The description is based on a number of full- scale exp

A new technique, liquid-liquid partition chromatography in an aqueous polyethylene glycol-dextran two-phase system, was used to detect differences in surface properties of antibodies with different antigen-binding sites. Employing well-characterized monoclonal IgG antibodies and Fab and Fc fragments thereof as well as chimeric IgG antibodies we found a remarkable relationship between structure of

Quantum chemical calculations, based on multiconfigurational wave functions and including relativistic effects, show that the U-2(2+) system has a large number of low-lying electronic states with S of 0 to 2 and Lambda ranging from zero to ten. These states share a very small bond length of about 2.30 angstrom, compared to 2.43 angstrom in neutral U-2. The Coulomb explosion to 2 U+ lowers the ener