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Mucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contraMucosa-associated lymphoid tissue protein 1 (MALT1) plays a key role in adaptive immune responses by modulating specific intracellular signalling pathways that control the development and proliferation of both T and B cells. Dysfunction of these pathways is coupled to the progress of highly aggressive lymphoma as well as to potential development of an array of different immune disorders. In contra

Sustainability and resilience are two related but distinct theories of coupled environmental and social systems. Both have been heavily debated and contested over recent decades, and both are highly relevant for understanding, managing, and living with and within riverine landscapes. In this chapter, I summarise key concepts of sustainability and social–ecological resilience theories and discuss t

Systems with strong electronic Coulomb correlations often display rich phase diagrams exhibiting different ordered phases involving spin, charge, or orbital degrees of freedom. The theoretical description of the interplay of the corresponding collective fluctuations giving rise to this phenomenology, however, remains a tremendous challenge. Here, we introduce a multichannel extension of the recent

The underlying mechanisms of many pain conditions are not known and many conditions have no effective treatment. Modern dynamic neuroimaging has increased the understanding of altered nervous system (CNS) processing in multiple pain conditions. This chapter describes the potential and the limitations of functional neuroimaging in the evaluation and treatment of clinical pain syndromes. It consider

Climate change predictions suggest that arctic and subarctic ecosystems will be particularly affected by rising temperatures and extreme weather events, including severe heat waves. Temperature is one of the most important environmental factors controlling and regulating microbial decomposition in soils; therefore, it is critical to understand its impact on soil microorganisms and their feedback t

Increased core body temperature and dehydration are critical thermal physiological responses to heat disorders. Dehydration is preventable through adequate water intake. However, a simple heat balance equation for assessing the heatstroke risk considering the core body temperature is currently lacking. Hence, this study proposes an equation for evaluating heatstroke risk. To derive the equation, t

Background: Patients with bacteraemia caused by gram-positive bacteria are at risk for infective endocarditis (IE). Because IE needs long antibiotic treatment and sometimes heart valve surgery, it is very important to identify patients with IE. Objectives: In this narrative review we present and discuss how to determine which investigations to detect IE that are needed in individual patients with