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The impact of a quadrivalent human papillomavirus (types 6, 11, 16, 18) virus-like particle vaccine in European women aged 16 to 24
Background Quadrivalent human papillomavirus (HPV types 6/11/16/18) L1 VLP vaccine is highly effective in preventing HPV 6/11/16/18-related cervical and external genital disease. Herein, we evaluated the impact of the quadrivalent HPV 6/11/16/18 L1 VLP vaccine on prevention of HPV-associated cervico-genital lesions in a broad population of sexually active European women. Methods Female subjects (N
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Physical activity and risk of endometrial cancer: The European prospective investigation into cancer and nutrition
The etiologic role of physical activity in endometrial cancer risk remains unclear given the few epidemiologic studies that have been conducted. To investigate this relation more fully, an analysis was,undertaken in the European prospective investigation into cancer and nutrition (EPIC). During an average 6.6 years of follow-up, 689 incident endometrial cancer cases were identified from an analyti
Functional properties of recombinant factor V mutated in a potential calcium-binding site.
Activated coagulation factor V (FVa) is a cofactor of activated factor X (FXa) in prothrombin activation. FVa is composed of a light chain (LC) and a heavy chain (HC) that are noncovalently associated in a calcium-dependent manner. We constructed a recombinant FV Asp111Asn/Asp112Asn mutant (rFV-NN) to abolish calcium binding to a potential calcium-binding site in FVa in order to study the specific
Palynology of Permian shale, clay and sandstone clasts from the Basen till in northern VestfJella, Dronning Maud Land
The palynological content of randomly collected sedimentary rock clasts from the till on the south-east slope of the Basen nunatak in northern Vestfiella in western Dronning Maud Land indicate that these sedimentary rocks were derived from strata of Middle Permian age. The palynological content and preservation is similar to palynofloras described from the sedimentary rocks that crop out at the Fo
In-depth characterization of CGRP receptors in human intracranial arteries
The purpose of the present study was to characterize the effects of human (h) alpha- and beta-calcitonin gene-related peptide (CGRP) on intracranial arteries from man and to investigate the presence of mRNA for the calcitonin receptor like receptor (CRLR) and the receptor activity modifying proteins (RAMPs) 1, 2 and 3, in cerebral and middle meningeal arteries with and without endothelium, in micr
Content versus delivery: Challenges and options in the treatment of schizophrenia
Seasonal and spatial variation in fungal biomass in a forest soil
Abstract in UndeterminedSoil fungal biomass, determined by the fluorescein diacetate (FDA) method, was studied during a 3 yr period in three horizons in a mature and a clear-cut pine forest in Sweden with and without slash left on the ground. In the organic soil layer the amount of hyphae showed a similar seasonal periodicity at all three sites, and this periodicity was correlated to the soil mois
Breeding origin and migration pattern of dunlin (Calidris alpina) revealed by mitochondrial DNA analysis.
The large-scale migration of birds has been studied extensively by recoveries of ringed birds. However, there is very little ringing data from the arctic breeding grounds of waders. Here, the migration pattern of the dunlin, Calidris alpina, is studied with population genetic markers, using haplotype frequencies to estimate the breeding origin of migrating and wintering populations. Polymerase cha
Unstable early-Holocene climatic and environmental conditions in northwestern Russia derived from a multidisciplinary study of a lake-sediment sequence from Pichozero, southeastern Russian Karelia
A sediment core from Lake Pichozero (61degrees46'; N, 37degrees25'; E 118 m a.s.l.) provides information on the environmental and climatic conditions in southeastern Russian Karelia during the Lateglacial and early Holocene (12800-9300 cal. BP). The chronology of the sequence is constrained by varve counting and AMS C-14 measurement of terrestrial plant macrofossils. Multiproxy analyses (magnetic
Acute mast cell-dependent neutrophil recruitment in the skin is mediated by KC and LFA-1: inhibitory mechanisms of dexamethasone.
Circulating oxidized low-density lipoprotein is increased in hypertension
Oxidized low-density lipoprotein (OxLDL) and autoantibodies to OxLDL (aOxLDL) are implicated in the development of atherosclerosis. The objective of this study was to determine the importance of these factors in hypertension, a major risk factor for atherosclerosis. Samples were obtained from I I I men with established hypertension (diastolic pressure > 95 mmHg) from the Swedish component of an on
Occupational factors and characteristics of the social network in people with persistent mental illness.
Associations between occupational factors and characteristics of the social network in people with persistent mental illness were investigated. Participant groups (N = 103) representing three types of daily occupations working or studying, visiting community-based activity centers, and having no regular daily occupation-were selected for the study. Participants were assessed regarding social inter
Heat-transfer distribution for an impinging laminar flame jet to a flat plate
Impinging flame jets are widely used in applications where high heat-transfer rates are needed, for instance in the glass industry. During the heating process of glass products, internal thermal stresses develop in the material due to temperature gradients. In order to avoid excessive thermal gradients as well as overheating of the hot spots, it is important to know and control the temperature dist
The influence of collembolans and earthworms on AM fungal mycelium
Arbuscular mycorrhizal (AM) mycelia are dependent on contact with plant roots for spore formation. In this study, earthworms and collembolans were regarded as potential dispersal vectors of AM fungal spores and hyphae, and we determined how they influenced the extension of AM fungi from host plant roots. Plantago lanceolata seedlings were grown in a mesh bag with an AM inoculurn of dried soil and
Triangulation of Points, Lines and Conics
The problem of reconstructing 3D scene features from multiple views with known camera motion and given image correspondences is considered. This is a classical and one of the most basic geometric problems in computer vision and photogrammetry. Yet, previous methods fail to guarantee optimal reconstructions - they are either plagued by local minima or rely on a non-optimal cost-function. A common f
Immediate breast reconstruction after mastectomy for cancer
AIMS: The oncological, surgical and cosmetic results, patient satisfaction and psychological morbidity of immediate breast reconstruction following mastectomy for breast cancer were evaluated. METHODS: From 1980 to 1994, 79 immediate breast reconstructions were performed in Malmo. From 1985 immediate breast reconstruction was performed in 21% of mastectomies among patients =65 years. The most co
Fluid shifts due to microgravity and their effects on bone: a review of current knowledge.
Floral changes across the Triassic/Jurassic boundary linked to flood basalt volcanism
One of the five largest mass extinctions of the past 600 million years occurred at the boundary of the Triassic and Jurassic periods, 201.6 million years ago. The loss of marine biodiversity at the time has been linked to extreme greenhouse warming, triggered by the release of carbon dioxide from flood basalt volcanism in the central Atlantic Ocean. In contrast, the biotic turnover in terrestrial
