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Risk of Birth Abnormalities in the Offspring of Men With a History of Cancer: A Cohort Study Using Danish and Swedish National Registries.

Background The potential mutagenic effects of cancer therapies and the growing number of young male cancer survivors have given rise to concern about the health of their offspring. Methods We identified all singleton children born alive in Denmark between 1994 and 2004 and in Sweden between 1994 and 2005 (n = 1 777 765). Of the 8670 children with a paternal history of cancer, 8162 were conceived n

Att forska om effekter av erfarenhetsbaserat lärande – några villkor för utvärdering av grupprelationskonferenser

This paper outlines possible strategies for evaluation of group relations conferences. Based on comparison of group relations and sensitivity training, the evaluations made of the latter are critically reviewed. Restriction to outcomes, means, variability measures, experimental paradigms and effect-without-process studies, instrumental views on learning and less developed conceptions of groups ham

Two Different Surgical Approaches in the Treatment of Adenocarcinoma at the Gastroesophageal Junction.

BACKGROUND: Adenocarcinoma at the gastroesophageal junction may be regarded as of esophageal or of gastric origin, and tumor removal may follow the principles of esophagectomy or extended gastrectomy. We determined the impact of this strategy on our patients with tumors at this site. METHODS: Baseline patient and tumor characteristics were collected, and tumors were categorized according to Siewer

Wnt5a induces a tolerogenic phenotype of macrophages in sepsis and breast cancer patients.

A well-orchestrated inflammatory reaction involves the induction of effector functions and, at a later stage, an active downregulation of this potentially harmful process. In this study we show that under proinflammatory conditions the noncanonical Wnt protein, Wnt5a, induces immunosuppressive macrophages. The suppressive phenotype induced by Wnt5a is associated with induction of IL-10 and inhibit

Exploring regression testing and software product line testing - research and state of practice

In large software organizations with a product line development approach a selective testing of product variants is necessary in order to keep pace with the decreased development time for new products, enabled by the systematic reuse. The close relationship between products in product line indicates an option to reduce the testing effort due to redundancy. In many cases test selection is performed