Regulation of angiopoietin-2 secretion from human pulmonary microvascular endothelial cells
INTRODUCTION: Sepsis is characterized by dysregulated systemic inflammation and cytokine storm. Angiopoietin-2 (Ang-2) is known to closely correlate with severity of sepsis-related acute lung injury and mortality. The aim of this study was to clarify the mechanisms involved in Ang-2 secretion to better understand the pathophysiology of sepsis.MATERIALS AND METHODS: The concentration of Ang-2 was a
