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A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show that the PET ligand, [18F]ACI-12589, displays good in vitro affinity and specificity for pathological α-synuclein in tissues from patients with different α-synuclein-related disorders including Parkinson’s disease (PD) an

We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but do not bind to the human angiotensin-converting enzyme 2 (ACE2) receptor. Cryo-EM analysis of the AnSAs yield high resolution structures (2.6–2.8 Å) indicating

The exponential-6 (exp-6) potential is commonly used to model fluids at high densities. In this paper, I propose a new equation of state (EOS) in the form of an analytical expression for the excess Helmholtz free energy of an exp-6 fluid. The EOS is based on extensive Monte Carlo simulations and therefore combines the excellent accuracy of the simulations with the numerical efficiency of a polynom

Manus till teaterföreställningen i ett hus vid skogens slut som gjordes på Turteatern i Stockholm."Vid civilisationens ände tittar människan yrvaket upp. En ångest som liknar en tomhet dånar i hennes inre. Strategierna för distraktion fungerar inte längre. Information flödar in i henne utan att hitta fästpunkter, politiken är lika död som de för länge sedan bortglömda gudarna, och själva pengasyst

AIMS: Heart failure (HF) patients with anaemia tend to have a worse outcome, with increased hospitalization rates, decreased exercise tolerance, and higher mortality compared to those without anaemia. Limited research exists on the association between selenium deficiency and anaemia specifically in HF patients, despite previous findings of a correlation in different populations. The BIOSTAT-CHF st

Denmark recently adopted a law to ban inappropriate treatment of any writing or object with religious significance – a peace initiative in the best interests of a multicultural society. I see this law as a step towards freedom of expression that will also help bridge social divides.

BackgroundObstructive sleep apnea (OSA) is a prevalent disorder and symptoms of nasal obstruction are highly prevalent in OSA. Treatment of nasal obstruction in OSA patients has shown modest and variable outcomes in reducing the apnea hypopnea index (AHI), but significant improvements in other indicators, such as sleep quality and daytime sleepiness as well as reductions in arousals have been obse

Linking clinical multi-omics with mechanistic studies may improve the understanding of rare cancers. We leverage two precision oncology programs to investigate rhabdomyosarcoma with FUS/EWSR1-TFCP2 fusions, an orphan malignancy without effective therapies. All tumors exhibit outlier ALK expression, partly accompanied by intragenic deletions and aberrant splicing resulting in ALK variants that are

Protoplanets growing within the protoplanetary disk by pebble accretion acquire hydrostatic gas envelopes. Due to accretion heating, the temperature in these envelopes can become high enough to sublimate refractory minerals which are the major components of the accreted pebbles. Here we study the sublimation of different mineral species and determine whether sublimation plays a role during the gro

Context. With data releases from the astrometric space mission Gaia, exploration of the structure of the Milky Way is now possible in unprecedented detail, and has unveiled many previously unknown structures in the Galactic disc and halo. One such feature is the Gaia phase spiral where the stars in the Galactic disc form a spiral density pattern in the Z- VZ plane. Many questions regarding the pha

Observed high spin states in 30Zn and 66Dy isotopes with two protons outside the closed shells at Z = 28 and Z = 64, respectively, are discussed and compared with cranked Nilsson-Strutinsky calculations. Bands terminating at higher and higher spin values are formed from successive proton excitations across these shells. These bands show very different features depending on the number of excited pa

The neutron rich 27Na was studied at Florida State University using the 14C(14C,p) reaction at 22 MeV. The 14C target was 0.28 mg/cm2 thick. γ-γ and particle-γ, coincidences were measured using 2 four-crystal clover detectors, 7 Compton-suppressed HPGe detectors, and a particle detector telescope at 0°. The 1757, 1823, and 2219 keV transitions are likely yrast transitions in 27Na. Based on systema

High spin states in 127La have been studied using the 32S(100Mo,p4n) reaction at a beam energy of 155 MeV. Gamma rays were detected using the EUROBALL III spectrometer. One of the side bands in 127La is observed to be populated to a spin of 83/2+. These data are compared with cranked Nilsson-Strutinski calculations which suggest that the structure is a smoothly terminating band, in valence space,

Excited states have been identified in the very neutron-deficient 119Ba nucleus. Two bands have been observed, which are likely to be based on h11/2 and (g7/2d5/2) neutron orbitals. Despite this being the first observation of excited states in 119Ba, the bands extend to (75/2)ℏ and (79/2)ℏ, respectively. The bands have been assigned to 119Ba using gamma-recoil and gamma-x-ray coincidences. Several

In atrial fibrillation (AF), the ECG P-wave, which represents atrial depolarization, is replaced with chaotic and irregular fibrillation waves (f waves). The f-wave frequency, F f, shows significant variations over time. Cardiorespiratory interactions regulated by the autonomic nervous system have been suggested to play a role in such variations. We conducted a simulation study to test whether t

Second harmonic generation is popular due to its numerous applications in different technologies dealing with multiple fields of science. The rapid technical advancement with the second harmonic generation demands parallel development in the theoretical understanding. With this view in mind, in our three papers, we theoretically investigated second harmonic generation from different systems in an