Therapeutic resistance and recurrence remain core challenges in cancer therapy. How therapy resistance arises is currently not fully understood with tumors surviving via multiple alternative routes. Here, we demonstrate that a subset of cancer cells survives therapeutic stress by entering a transient state characterized by whole-genome doubling. At the onset of the polyploidization program, we ide

This thesis examines housing as a human right and issues of housing inequality in a Swedish context. The aim is to examine discourses on housing, particularly centred on renovation causing rent increases in rental apartments owned by a public housing company in Sweden. The material constitutes of legal documents from two cases in the rent tribunal, one interview with a representative of the Swedis

As the climate changes the risks to agriculture increases which is a threat to food security around the world. One such risk is an increase in rainfall which can lead to decreased crop yields. Sweden today is dependent on other countries for their food supply, however the countries it depends on will suffer more from climate related risks to their agriculture meaning that Sweden's own food pro

Transition metal ions play crucial roles in the structure and function of numerous proteins, contributing to essential biological processes such as catalysis, electron transfer, and oxygen binding. However, accurately modeling the electronic structure and properties of metalloproteins poses significant challenges due to the complex nature of their electronic configurations and strong correlation e

The sPHENIX Time Projection Chamber Outer Tracker (TPOT) is a Micromegas based detector. It is a part of the sPHENIX experiment that aims to facilitate the calibration of the Time Projection Chamber, in particular the correction of the time-averaged and beam-induced distortions of the electron drift. This paper describes the detector mission, setup, construction, installation, commissioning and pe

Based on the Shidi-1 drill core, this paper presents new and highly time resolved carbon isotope data (δ13Ccarb) for the Early Ordovician through Early Silurian of the Yangtze Platform, South China. Five carbon isotopic shifts (C1-C5) through the late Tremadocian to the Katian have been recognized in the Shidi-1 drill core recordings. Together with previously published isotope data, a composite ca

β-d-Galp-(1→3)-d-GalNAc (1) was synthesised from lactose and GalNAc on a mmolar scale by transgalactosylation using β-d-galactosidase from bovine testes. The large proportions of unwanted oligosaccharides in the product mixture were removed by treatment with β-d-galactosidase from E. coli, which left 1, monosaccharides, and a small proportion of trisaccharides. Carbon-Celite chromatography then ga

Structural systems in seismic-prone regions can experience sudden deterioration caused by earthquake-induced ground-motion sequences. In addition, given the prevailing environmental conditions at their site, these systems may undergo gradual deterioration resulting from environment-induced mechanisms. The combined impacts of such phenomena can result in significant structural/non-structural damage

The deterioration of engineering systems might reduce the system reliability and prompt maintenance operations that may disrupt the ability of the systems to provide regular service. Estimating the Remaining Useful Life (RUL) of the system requires an understanding of the deterioration processes acting on it. Recent formulations have shifted the focus of deterioration modeling from the system as a

The use of pheromones, while common, remains underexplored in mosquito research. Understanding Aedes aegypti's mating behaviour and pheromones is crucial for expanding knowledge and advancing vector control strategies. Unlike other species, Aedes mosquitoes have adaptable mating behaviour, complicating the study of their communication mechanisms. Current literature on Aedes communication is sparse

The reversal of the hydrolytic activity of α-mannosidase from jack bean has been studied in high concentrations of mannose. From an initial concentration of 85% mannose (w/w), a maximum yield of 70% (w/w) di- and oligosaccharides was obtained. The products were separated by gel chromatography and high-performance liquid chromatography, and characterized by gas-liquid chromatographymass spectrometr

Galβ1-3GlcNAc (1) and Galβ1-3GlcNAcβ-SEt (2) were synthesized on a 100 mg scale by the transgalactosylation reaction of bovine testes β-galactosidase with lactose as donor andN-acetylglucosamine and GlcNAcβ-SEt as acceptors. In both cases the product mixtures contained unwanted isomers and were treated with β-galactosidase from Escherichia coli which has a different specificity, under conditions f

In this paper, I try to reconcile the vulgar (normative) definition of punishment with the positivistic (purely descriptive) definition that separates the ethics of punishment from its definition—punishment positivism. I will argue that although the vulgar definition has critical issues, this does not mean that we should stop using normative concepts in the definition of punishment. I will attempt

This paper presents the data constituting the catalogue of animal bones from Iron Age settlements in Scania, as published in the book “Animal husbandry in Iron Age Scania, with a catalogue”, and part of the Sheep Ahoy project at Lund University. The dataset consists of osteological data from zooarchaeologically examined animal bone assemblages from Iron Age settlement sites in Scania. The data has