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Infection represents an evolutionary arms race between pathogen and host. Thus, scientists find that pathogenic microbes have evolved elegant strategies to manipulate or avoid our immune system, allowing them to persist within the human population. This thesis is largely focused on how bacteria regulate and exploit the type I interferon (IFN) response in infected macrophages – a processes of centr
Nitrate pollution of groundwater has increased dramatically worldwide due to increase of population and agricultural productivity. The resulting nitrate concentration in groundwater is usually a combination of various types of point and non-point pollutant sources. It is often difficult to distinguish between these sources since groundwater is formed in large and complex catchments with various na
Limited guidance is available to engineers on how people's walking speed in smoke can and should be represented in the fire safety design process of underground transportation systems, such as road and rail tunnels. To address this issue, the behaviour and movement of people in case of evacuation due to a fire in underground transportation systems has been investigated. In this paper, the relation
We present a simple microfluidic-based synthesis protocol to fabricate snowman like Janus hydrogel particles of poly(N-isopropylacrylamide) (PNIPAM) in micron length scale. Particles are synthesized by emulsifying a hydrogel solution (water (w)/oil (o)) followed by partial solvent evaporation. Solvent evaporation allows the hydrogels to concentrate within the droplet and phase separate into a mono
Objective: As digital technologies for health continue to develop, the ability to provide primary care services to patients with new symptoms will grow. In Sweden, two providers of digital primary care have expanded rapidly over the past years giving rise to a heated debate with clear policy implications. The purpose of the study is to present a descriptive review of digital primary care as curren
Species-rich sandy calcareous grasslands are threatened by land use change, eutrophication and acidification. Disturbance is vital for the persistence of characteristic sandy calcareous grassland species because it provides habitats with low competition, and can lead to increased pH and decreased nutrient availability, which favour many threatened species. Today many sandy calcareous grasslands la
The purpose of this research is to study the impact of temperature, precipitation, and wind speed on in situ concrete wall operations, and its combined resulting effect on project duration. The research presented is anchored in the learnings gained through a literature review on weather effects on construction operations, an analysis of weather data with high resolution, and two field studies of i
The mixing process of a liquid jet in supersonic crossflow with a Mach number of 2.1 was investigated numerically using large eddy simulation (LES) based on the Eulerian-Lagrangian method. The gas phase was described using the Navier-Stokes equations and the liquid phase was represented using discrete droplets, which were injected and tracked in the computational domain individually according to N
Introduction: The Visual Ergonomics Risk Assessment Method (VERAM) is a newly developed and validated method to assess visual ergonomics at workplaces. VERAM consists of a questionnaire and an objective evaluation. Objective: To evaluate reliability of VERAM by assessing test-retest reliability of the questionnaire, and intra- and inter-rater reliability of the objective evaluation. Methods: Forty
A measurement of the production of prompt Λ c + baryons in Pb–Pb collisions at s NN =5.02 TeV with the ALICE detector at the LHC is reported. The Λ c + and Λ‾ c − were reconstructed at midrapidity (|y|<0.5) via the hadronic decay channel Λ c + →pK S 0 (and charge conjugate) in the transverse momentum and centrality intervals 6
Aims of the study: Neurological impairment after resuscitated cardiac arrest (CA) remains a significant unmet medical need. Brain ischemia associated with CA and subsequent reperfusion is evident as two fundamentally different types of damage on neuropathological examination: frank necrosis (involving all cell types) and selective eosinophilic neuronal death (SEND). These types of damage are not o
American Foulbrood (AFB) is a particularly pernicious bacterial disease of honey bees due to the extreme persistence of endospores of the causative agent Paenibacillus larvae. These spores are resistant to harsh environmental conditions, unaffected by antimicrobial agents and can remain viable for decades. The germination of the endospore in the larval midgut is the crucial first step leading to i
Background: Apolipoprotein M (apoM) is a 25-kDa apolipoprotein present in 5% of high-density lipoprotein (HDL) particles. It is suggested to be anti-atherogenic and to play a key role in sustaining endothelial barrier integrity. SLE patients have increased cardiovascular disease risk, and we aimed to investigate if apoM levels reflect endothelial function in SLE. Since apoM plasma levels decrease
