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High-throughput analysis of the structural evolution of the monoolein cubic phase in situ under crystallogenesis conditions

We have tracked the structural evolution of the monoolein bicontinuous cubic phase under in meso crystallogenesis conditions. Significantly, all measurements have been carried out in situ within a crystallisation plate reproducing the exact conditions during a crystallisation trial. The structure of the MO cubic phase, doped with a small concentration of amyloid-beta peptide, was measured 1 day, 5

Self-efficacy in the context of heart transplantation - a new perspective

AIMS AND OBJECTIVES: An in-depth exploration of self-efficacy among heart transplant recipients by means of Bandura's self-efficacy theory.BACKGROUND: An essential component of chronic illness management is self-management, which refers to activities carried out by people to create order, structure and control in their lives. Self-efficacy is an important aspect of self-management, which seems to

A new Buttiauxella phytase continuously hydrolyzes phytate and improves amino acid digestibility and mineral balance in growing pigs fed phosphorous-deficient diet

Ten ileal T-cannulated pigs (19.26 ± 1.06 kg) were used to evaluate the effects of a novel Buttiauxella phytase on apparent ileal digestibility (AID) of AA and apparent total tract digestibility (ATTD) and hindgut disappearance of DM, GE, CP, crude fiber, NDF, and ADF as well as minerals balance. Pigs were fed in a duplicated 5 × 4 incomplete Latin square design (5 diets with 4 periods). Each peri

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Review of Avner Offer & Gabriel Söderberg, The Nobel Factor

Identification of SLPI (Secretory leukocyte protease inhibitor) in human mast cells using immunohistochemistry and in situ hybridisation

Recently interest has been focused on secretory leucocyte protease inhibitor (SLPI) and its role in immediate hypersensitive reactions, possibly by inhibiting mast cell chymase. The purpose of this investigation was to show whether or not SLPI is produced in mast cells. Double-immunolabelling revealed that SLPI coexists with mast cell tryptase (60%) and chymase (37%). On the other hand, in situ hy

Cylindrical multipole expansion for periodic sources with applications for three-phase power cables

This paper presents a cylindrical multipole expansion for periodic sources with applications for three-phase power cables. It is the aim of the contribution to provide some analytical solutions and techniques that can be useful in the calculation of cable losses. Explicit analytical results are given for the fields generated by a three-phase helical current distribution and which can be computed e

Thymic retention of CD4+CD25+FoxP3+ T regulatory cells is associated with their peripheral deficiency and thrombocytopenia in a murine model of immune thrombocytopenia

Immune thrombocytopenia (ITP) is a bleeding disorder in which antibodies and/or T cells lead to enhanced peripheral platelet destruction and reduced bone marrow platelet production. Several reports have observed that ITP is associated with a peripheral deficiency of tolerance-inducing CD4+CD25+FoxP3+ T regulatory cells (Tregs). Using a murine model of ITP, we analyzed Tregs in the spleen and thymu

Single nucleotide polymorphism (SNP) analysis demonstrates a significant association of tumour necrosis factor-alpha (TNFA) with primary immune thrombocytopenia among Caucasian adults

T-helper 1 polarization in patients with primary immune thrombocytopenia (ITP) is well documented. However, the genetic contribution to this imbalance remains unclear. To address this question, we selected six candidate single nucleotide polymorphisms within cytokine or cytokine receptor genes for association testing among Caucasian adults. Patients from the United Kingdom Adult ITP Registry were

Matched filtering and the ecology of vision in insects

In the words of Wehner (J Comp Physiol A 161:511–531, 1987) who first coined the term “matched filter” in the context of sensory systems, matched filters “severely limit the amount of information the brain can pick up from the outside world, but they free the brain from the need to perform more intricate computations to extract the information finally needed for fulfilling a particular task”. In o

Evaluating the impact of climate change on the risk assessment of Nuclear Power Plants

Technical Systems, Structures and Infrastructures (SSI) ought to be designed to be safe under current but also future environmental (climate) conditions. Therefore, there is a need to rigorously identify procedures to systematically consider different climate conditions into the risk assessments. In this paper, we consider climate change in the risk assessment of a Passive Containment Cooling Syst

The first Team Haemophilia Education meeting, 2015, Amsterdam, The Netherlands

Haemophilia remains a complex disorder to diagnose and manage, requiring close cooperation between multidisciplinary healthcare professionals. There are still many unmet challenges in haemophilia care. The first Team Haemophilia Education (THE) meeting, held on 7–8 May 2015 in Amsterdam, The Netherlands, aimed to promote the optimal care of haemophilia patients through education of the multidiscip

Tensed evidentials : a typological study

To gain more insight into evidentiality, the grammatical marking of information source, it is worth studying the category in its relation to other grammatical categories. This study explores tensed evidentials, morphemes in which tense and evidentiality are fused, in 36 languages from four macro-areas (North America, South America, Eurasia, and Papunesia). The study reveals several interactions be

Extremvärme ett ökande problem för globala folkhälsan : Klimatförändringarnas negativa hälsoeffekter drabbar även Sverige

High temperatures have a direct impact on body functions. Heat waves increase mortality risks due to myocardial infarction, stroke, and pulmonary disease. Cold temperatures also increase mortality, but with a longer latency. A recent study found only a small difference between the minimal mortality temperature (MMT) and the temperatures at which mortality rose steeply, although the majority of dea

Memory formation orchestrates the wiring of adult-born hippocampal neurons into brain circuits

During memory formation, structural rearrangements of dendritic spines provide a mean to durably modulate synaptic connectivity within neuronal networks. New neurons generated throughout the adult life in the dentate gyrus of the hippocampus contribute to learning and memory. As these neurons become incorporated into the network, they generate huge numbers of new connections that modify hippocampa

Evaluation of platelet gel characteristics using thrombin produced by the thrombin processing device : a comparative study

PURPOSE: Autologous platelet gels can be prepared using the patient's own platelet-rich plasma and thrombin produced by the Thrombin Processing Device (Thermogenesis Corp, Rancho Cordova, CA). As the Thrombin Processing Device thrombin contains a residual amount of ethanol, the purpose of this study was to investigate the effect of the Thrombin Processing Device thrombin on growth factor release f