Subungual exostosis is a benign bone- and cartilage-forming tumor known to harbour a pathognomonic t(X;6)(q22;q13-14). Using global gene expression analysis and quantitative real-time PCR we could show that this translocation results in increased expression of the IRS4 gene, presumably due to disruption and/or exchange of regulatory sequences with the translocation partner, the COL12A1 gene. A cor

The language policies of three Swedish universities are examined as instances of language planning in local contexts. Although Sweden has the national Language Act of 2009 as well as a general Higher Education Ordinance (SFS 1993:100; SFS 2014:1096), language planning for higher education is left to the purview of individual institutions. Since language planning in local contexts often involves th

In this paper we give a unified framework for constructing harmonic morphisms from the irreducible Riemannian symmetric spaces HHn, CHn, RH2n+l, HPn, CPn and RP2n+1 of rank one. Using this we give a positive answer to the global existence problem for the non-compact hyperbolic cases.

An infinite summation method is used to obtain the intrinsic photoemission spectrum of a conduction electron in the sudden limit. It is predicted that an electron at the bottom of the conduction band should have an asymmetry index comparable to that of a core electron and that the strengths of its plasmon satellites should be similar to those of a core electron. The width of their plasmon satellit

Objective: To test the hypotheses that the empirical consideration of objective person-environment fit in the home environment is a stronger predictor of indoor falls among older adults than the assessment of environmental barriers only, and that perceived aspects of home play a role as predictors for falls.Design: Survey study with data collection at home visits, followed up by self-reports about

AIM: The aim of the present retrospective study was to investigate the influence of neoadjuvant chemotherapy on liver regeneration after portal vein occlusion before major hepatectomy. METHOD: Between 2003 and 2007, 26 patients underwent portal vein occlusion, of whom 22 had portal vein embolisation and 4 portal vein ligation. 15 of 23 patients with colorectal liver metastases had neoadjuvant chem

Design science research is an essential part of IS research since the field should not only try to understand how the world is, but also how to change it. We argue that the aim of IS design science research should be to develop practical knowledge not only for the design of novel information technology (IT), but also for IS governance and management. Whereas at least some methodological support ex

A defective form of the AIRE protein causes autoimmune destruction of target organs by disturbing the immunological tolerance of patients with a rare monogenic disease, autoimmune polyendocrinopathy (APE)-candidiasis (C)-ectodermal dystrophy (ED), APECED. Recently, experiments on knockout mice revealed that AIRE controls autoimmunity by regulating the transcription of peripheral tissue-restricted

Seawater desalination constitutes an important source for water supply to the population bordering the Arabian Gulf, the Mediterranean Sea, and the Red Sea. The three regions represent about 11.8% of the world land area and the countries hosted approximately 9% of the world population in 1950 and 2008 and are projected to do so again in 2050. Population statistics for a 100-year period has been us

Accumulation of alpha-synuclein is a pathological feature in several neurological diseases. Its characterization has allowed for a re-grouping of diseases according to the expected pathology. The clinical syndrome of PD can now be classified into forms with and without alpha-synuclein pathology. DLB and PDD are synucleinopathies, and MSA shows alpha-synuclein pathology with glial inclusions. ADHD

The aims of this study were to describe the participation in physical activity of children with cerebral palsy (CP) at school and during leisure time and to identify characteristics associated with physical activity. The frequency of receiving physiotherapeutic interventions were described as a variable of interest. A total population of 364 children with verified CP aged 7-17 years living in the

Aim: Nasal transient receptor potential vanilloid 1 (TRPV1) stimulation with capsaicin produces serous and mucinous secretion in the human nasal airway. The primary aim of this study was to examine topical effects of various TRP ion channel agonists on symptoms and secretion of specific mucins: mucin 5 subtype AC (MUC5AC) and B (MUC5B). Methods: Healthy individuals were subjected to nasal challeng

Cap rock integrity is an essential characteristic of any reservoir to be used for long-term CO 2 storage. Seismic AVOA (amplitude variation with offset and azimuth) techniques have been applied to map HTI anisotropy near the cap rock of the Weyburn field in southeast Saskatchewan, Canada, with the purpose of identifying potential fracture zones that may compromise seal integrity. This analysis, su

It is yet unknown to which degree young subfertile men present with signs of hypogonadism and whether low testosterone concentration, like in older men, is associated with risk of osteoporosis and metabolic derangements in those subjects. The objective was, therefore, to investigate the prevalence of hypogonadism and its association with metabolic and bone parameters in young subfertile men.

Patient safety is an important global issue. While it is well known that patients can suffer from adverse events in nursing care, there is a lack of knowledge as to how they experience them.

BACKGROUND: Polysubstance use is common in substance users, and may complicate their clinical course. This study, in a criminal justice setting in Sweden, examines the association between the number of concurrently used substance types and psychiatric symptoms during 30 days before incarceration, while controlling for background variables such as family history (drug and alcohol problems, psychiat

A modified local error model is developed for numerical integration of ODEs with invariants. The basic idea is to use a commutativity relationship that holds for implicit state-space form methods. A new implicit state-space form predictor is developed from which error estimates can be obtained by predictor-corrector difference: This technique is demonstrated through the preliminary examples in thi

Summary The t(X;7)(q22;q34), a translocation not previously reported in a neoplastic disorder, was identified and molecularly characterised in a paediatric T-cell acute lymphoblastic leukaemia (T-ALL), subsequently shown also to harbour a deletion of 6q, a STIL/TAL1 fusion and an activating NOTCH1 mutation. The t(X;7) was further investigated using fluorescence in situ hybridisation (FISH), real-t