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Balancing effluent quality, greenhouse gas emissions and operational cost - developing dynamical models for intergrated benchmarking of wastewater treatment plants

The scope for wastewater treatment plants (WWTPs) widens to consider not only water quality and cost, but also energy efficiency and greenhouse gas (GHG) emissions. The on-going research project, “Development and dynamic analysis of operational strategies for enhanced energy efficiency of wastewater treatment systems” aims to develop a tool for integrated evaluation of energy efficiency and greenh

Increased sensitivity to bleomycin in upper aerodigestive tract mucosa of head and neck squamous cell carcinoma patients.

Previous studies on lymphocytes have suggested that patients with head and neck squamous cell carcinoma (HNSCC) have an increased susceptibility for chromosomal damage induced by bleomycin, a known radiomimetic mutagen. However, it has so far not been possible to study whether this genetic instability is present also in the epithelial component of the upper aerodigestive tract mucosa, the tissue f

Kolitcancer - mer myt än verklighet?

Patients with ulcerative colitis (UC) and Crohn´s colitis are at increased of developing colorectal cancer (CRC). However, recent studies suggest that the risk is now less than previously thought. Well established risk factors include extent and duration of disease, primary sclerosing cholangitis (PSC) and a family history of CRC. Recently inflammation (both microscopic and macroscopic) has been s

Konst och Vetenskap: Om ett annorlunda möte

Idag utvecklas så mycket kunskap genom en strid ström av korta forskningsprojekt att det långvariga börjar höra till ovanligheterna. Just därför har vi stannat till inför det i dag 7-åriga samspelet mellan Tryckolera och Certec. Även det var ursprungligen ett tidsavgränsat projekt. Vad är det som har gett det en sådan bärkraft genom åren? Svaret överraskade oss själva: uthålligheten har uppkommit

Self-expanding metal stents in malignant colonic obstruction: experiences from Sweden.

BACKGROUND: Acute surgery in the management of malignant colonic obstruction is associated with high morbidity and mortality. The use of self-expanding metal stents (SEMS) is an alternative method of decompressing colonic obstruction. SEMS may allow time to optimize the patient and to perform preoperative staging, converting acute surgery into elective. SEMS is also proposed as palliative treatmen

Deaf teenagers with cochlear implants in conversation with hearing peers.

Background: This study investigates the use of requests for clarification in conversations between teenagers with a cochlear implant (CI) and hearing peers. So far very few studies have focused on conversational abilities in children with CI. Aims: The aim was to explore co-construction of dialogue in a referential communication task and the participation of the teenagers with CI in comparison wit

Enhanced cerebrovascular expression of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 via the MEK/ERK pathway during cerebral ischemia in the rat.

BACKGROUND: Cerebral ischemia is usually characterized by a reduction in local blood flow and metabolism and by disruption of the blood-brain barrier in the infarct region. The formation of oedema and opening of the blood-brain barrier in stroke is associated with enhanced expression of metalloproteinase-9 (MMP-9) and tissue inhibitor of metalloproteinase-1 (TIMP-1). RESULTS: Here, we found an inf

Children diagnosed with type 1 diabetes: a randomized controlled trial comparing hospital versus home-based care.

Aim: To compare two different regimens for children diagnosed with type 1 diabetes: hospital-based care or hospital-based home care (HBHC), referring to specialist care in a home-based setting. Method: The trial took place in Sweden with a randomized controlled design and included 60 children, aged 3-15 years. After 2-3 days with hospital-based care, children were randomized to either continue

Symptomatic atherosclerosis is associated with an altered gut metagenome

Recent findings have implicated the gut microbiota as a contributor of metabolic diseases through the modulation of host metabolism and inflammation. Atherosclerosis is associated with lipid accumulation and inflammation in the arterial wall, and bacteria have been suggested as a causative agent of this disease. Here we use shotgun sequencing of the gut metagenome to demonstrate that the genus Col

USING AN OPTIMISED OSL SINGLE-ALIQUOT REGENERATIVE-DOSE PROTOCOL FOR LOW-DOSE RETROSPECTIVE DOSIMETRY ON HOUSEHOLD SALT.

The single-aliquot regenerative-dose (SAR) protocols used in retrospective dosimetry for optically stimulated luminescence measurements have been mainly developed for archaeological and geological dating of quartz and feldspar. The aim in this study is to find a read-out protocol that can generate the most reproducible signal for household salt (NaCl) at absorbed doses below 100 mGy. The relation

MICRODOSING FOR EARLY BIOKINETIC STUDIES IN HUMANS.

Microdosing is a new concept in drug development that-if implemented in the pharmaceutical industry-would mean that new drugs can be tested earlier in humans than done today. The human microdosing concept-or 'Phase 0'-may offer improved candidate selection, reduced failure rates in the drug development line and a reduction in the use of laboratory animals in early drug development, factors which w

Minimal and canonical rational generator matrices for convolutional codes

A full-rank IC x n matrix G(D) over the rational functions F(D) generates a rate R = k/n convolutional code C. G(D) is minimal if it can be realized with as few memory elements as any encoder for C, and G(D) is canonical if it has a minimal realization in controller canonical form. We show that G(D) is minimal if and only if for all rational input sequences p1 (D), the span of U (D) G (D) covers t

Plant nitrate use in deciduous woodland: the relationship between leaf N, N-15 natural abundance of forbs and soil N mineralisation

Our aim was to study whether the in situ natural abundance N-15 (delta(15)N)-values and N concentration of understory plants were correlated with the form and amount of mineral N available in the soil. Also to determine whether such differences were related to earlier demonstrations of differences in biomass increase in the same species exposed to nutrient solutions with both NO3- and NH4+ or to N

Disturbed vibrotactile sense in finger pulps in patients with Type 1 diabetes-correlations with glycaemic level, clinical examination and electrophysiology.

Aims In a cohort of men and women with Type 1 diabetes, prospectively followed for > 20 years, vibrotactile sense in fingers was investigated and related to neurophysiological tests, glycaemic level and clinical score. Methods Out of 58 patients, diagnosed at the age of 15-25 years and recruited 1984-1985, 32 patients (13 women, median age 52 years, range 44-75 years; 19 men, median age 52 years,