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Background: Type 2 diabetes (T2D) is associated with increased risk of complications after breast cancer surgery. This study investigated systemic and surgical-site postoperative complications and the risk of early and late breast cancer recurrence and mortality, overall, and according to T2D status. Methods: From the Danish Breast Cancer Group (DBCG) and Danish registries, a cohort of women with
Context. The young β Pictoris system has been monitored with high-resolution optical spectrographs for decades. These observations have revealed strongly variable stochastic absorption in the Ca II H&K lines attributed to infalling cometary bodies. Aims. Since 2003, over 9000 HARPS observations of β Pictoris have been taken, and many of these have not yet been used for exocomet studies. We aim
Fluorescence microscopy is an effective tool for imaging biological samples, yet captured images often contain noises, including photon shot noise and camera read noise. To analyze biological samples accurately, separating background pixels from signal pixels is crucial. This would ideally be guided by the knowledge of a parameter called the Poisson parameter, 𝜆bg, representing the mean number of
Importance: Prenatal intensive behavioral therapy (IBT) interventions that promote adequate gestational weight gain (GWG) have had variable and mostly modest effects on clinically relevant maternal and infant outcomes. It is unknown whether different maternal obesity metabolic phenotypes underlie the heterogeneity in response. Objective: To examine GWG, adverse perinatal outcomes, substrate change
This study examines the determinants of environmentally responsible behavior among tourists in the heritage villages of Paveh County, Iran, through an integrated theoretical framework that synthesizes place-related psychological constructs with the Theory of Planned Behavior (TPB). Employing structural equation modeling on data collected from 443 tourists across three heritage villages (July–Novem
This paper presents a reflexive, transdisciplinary reassessment of the Nabberör boat grave, dated to the 8th century CE, on the Baltic island of Öland. The osteological material and the grave goods are carefully re-examined and recontextualised using a multiproxy approach, including new archaeological, bioarchaeological, zooarchaeological, isotopic, and aDNA analyses. The results reveal a multiple
Background/Objectives: Intraoperative frozen biopsies are essential during surgery for Hirschsprung’s disease (HD). However, this method has several limitations with the need for a faster and real-time diagnostic alternative. For this, consistent histoanatomical and morphometric differences between aganglionic and ganglionic bowel must be established. The primary objective was to compare dimension
In this paper, we investigate how adaptive time-integration strategies can be effectively combined with parallel-in-time numerical methods for solving systems of ordinary differential equations. Our focus is particularly on their influence on tolerance proportionality. We examine various grid-refinement strategies within the multigrid reduction-in-time (MGRIT) framework. Our results show that a si
The Kunming-Montréal Global Biodiversity Framework, adopted at COP15, establishes a clear mandate to mobilize funding from diverse sources to address the escalating biodiversity crisis. Despite growing awareness and commitment to biodiversity conservation, a substantial financing gap persists, hindering efforts to protect and restore ecosystems effectively. This chapter provides an in-depth examin
Radiographic axial spondyloarthritis (r-axSpA) is associated with increased cardiovascular disease (CVD) risk. The coronary artery calcification (CAC) score, an atherosclerosis burden indicator that predicts CVD risk, is not well studied in r-axSpA. This study investigates CAC scores in patients with r-axSpA compared to controls without rheumatic disease and factors associated with CAC scores in r
Background: Treatment with antihypertensives in patients with advanced cancer is often continued until very late in the disease trajectory, despite a considerable risk of hypotension. Objectives: The aim of this study was to investigate the time of deprescribing of antihypertensive agents in patients with cancer receiving palliative care during their last year of life. The monitoring of blood pres
Sex-based differences in immune responses are a well-established phenomenon, with males generally displaying stronger innate immunity and females exhibiting enhanced adaptive responses. The androgen receptor (AR) is the main effector of androgen-induced changes in the body through genomic transcription and has been implicated as one of the origins of sex-based differences in immunity. This thesis
Alzheimer's disease (AD) is a neurodegenerative disease that often occurs in the elderly and is often accompanied by cognitive loss. Its main pathological features are the formation of amyloid-beta (Aβ) plaques and Tau tangles in the brain. Here, we used single-cell RNA sequencing (scRNA-seq) combined with computational cell–cell communication (CCC) analysis to systematically investigate trans
Papain-like protease (PLpro) of SARS-CoV-2 is a vital enzyme involved in viral polyprotein processing and in the suppression of host immune response. Due to its strategic role in viral replication and pathogenesis, PLpro represents a valid yet challenging target for drug development. Fragment-based drug discovery (FBDD) is a powerful strategy employed by the FragMAX facility at MAX IV to identify
Landskronas öppna verkstad undersöker hur ett mindre tillägg i en urban kontext kan bidra till en ökad aktivering av närområdet och samtidigt ge utrymme för ökad rörelse från resten av staden. Projektet tar sin utgångspunkt i ambitionen att skapa ett genomarbetat förslag som förhåller sig till de funktionella krav som ställs, samtidigt som det är starkt förankrat i sin kontext. Projektet prövar id
Consistent behavioural differences among individuals can have significant ecological and evolutionary consequences, yet their origins and persistence within populations have proven challenging to determine. In newly established populations at expanding range margins, behavioural variation may result from natural selection and spatial sorting, with behavioural types that promote dispersal being mor
Två flugarter: mer alkohol, mer sex? Artbildning är en av de viktigaste processerna inom evolutionsbiologi. För att en art ska bli två krävs det att arten formar två grupper som inte reproducerar sig med varandra. Om en sådan reproduktiv isolering, som det kan kallas, fortgår i flera generation kan så pass många genetiska skillnader åsamlas mellan grupperna att hybrider (avkommor från två olika tSexually reproducing species tend to have reproductive barriers between them that prevent hybrid offspring from being formed. Drosophila melanogaster and D. simulans are two closely related species that can form sterile hybrids. In addition to their post-zygotic barriers, which cause the hybrid sterility, some behavioral pre-zygotic barriers also exist. These include different preferences for cour
Rare divergent RNAs in disease In human cells, genes are transcribed into an RNA before being translated into a protein, but first its structure under strict regulation undergoes changes called RNA splicing. Premature RNAs are organized in exon and intron units, where the latter are removed, to join exons together in the mature RNA. However, a variation of exon/intron combination can occur via a
Praematurum – mutanterna som snabbar på blomningen i korn Hordeum vulgare (känt som ”korn” i vardagligt språk) är idag världens fjärde mest odlade sädesslag och används framför allt som djurfoder och till ölbryggning. På grund av den globalt ökande populationen och ett nyligen återfunnet intresse i nationell självförsörjning så blir vikten av forskning inom växtförädling bara större och större. EWhen cultivating barley (Hordeum vulgare), access to cultivars with shorter flowering time can be helpful in various agricultural settings, such as the effort of expanding agricultural capabilities into colder regions with shorter growing seasons. The recently identified gene Praematurum-b (Mat-b) is known to cause the plants to flower 7 days early on average. This thesis aimed to analyze the effe
