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Rationale: Idiopathic pulmonary fibrosis (IPF) is a chronic dysregulated response to alveolar epithelial injury with differentiation of epithelial cells and fibroblasts into matrix-secreting myofibroblasts resulting in lung scaring. The prognosis is poor and there are no effective therapies or reliable biomarkers. Galectin-3 is a beta-galactoside binding lectin that is highly expressed in fibrotic
The metabolic syndrome (MetS), characterized by obesity, hyperlipidemia, hypertension, and insulin resistance, is a growing epidemic worldwide, requiring new prevention strategies and therapeutics. The concept of prebiotics refers to selective stimulation of growth and/or activity(ies) of one or a limited number of microbial genus(era)/species in the gut microbiota that confer(s) health benefits t
We have attached quaternary ammonium (QA) groups to poly(phenylene oxide) via flexible and stable heptyl side chains by using a straightforward synthetic route involving bromoalkylation and quaternization. Membranes based on these polymers showed efficient phase separation, significantly enhanced hydroxide ion conductivity and far superior alkaline stability in relation to corresponding polymers w
Poly (ethylene-co-vinyl acetate) (EVA)/clay nanocomposites containing two different organoclays with different clay loadings were prepared. The transport of gases (oxygen and nitrogen) through the composite membranes was investigated and the results were compared. These studies revealed that the incorporation of nanoclays in the polymer increased the efficiency of the membranes toward barrier prop
Breast cancer is the most common cancer form among women today. Depending on hormone receptor status, breast cancers are divided into different subtypes with vastly varying prognosis. S100A9 is a calcium-binding protein that is associated with inflammation and expressed not only in myeloid cells but also in some tumours. The role for S100A9 in the malignant cells is not well characterised; however
Green products are becoming part of contemporary consumer cultures and part of everyday life. But how are green products constructed? What kind of green products are constructed? And what happens as these green products are constructed? The aim of this paper is to contribute a socio-cultural and critical understanding of green marketing by exploring and illustrating how marketing practices work t
Protein stability assessment of seven model proteins in the presence of low molecular weight polyethyleneimine (PEI, MW 2000 Da) was performed. Thermodynamic stability, monitored by circular dichroism (CD) spectroscopy, showed that the polymer did not have a major effect on the melting temperature (T-m) of the basic proteins - muscle lactate dehydrogenase (LDH), ribonuclease A, lysozyme and cutina
Background: The frequency and prognostic importance of atrial fibrillation (AF) in asymptomatic mild-to-moderate aortic stenosis (AS) has not been well described. Methods: Clinical examination, electrocardiography and echocardiography were obtained in asymptomatic patients with mild-to-moderate AS and preserved left ventricular (LV) systolic function, randomized to simvastatin/ezetimibe combinatio
Introduction Evacuation from tunnel fire emergencies requires quick decision-making and swift action from the tunnel occupants. Social influence (SI) has been identified as an important factor in evacuation. Methods Two experimental groups were immersed into a virtual road tunnel fire. In the SI group participants saw a virtual agent moving on the shortest route to the nearest emergency exit. In
Allopolyploidization often happens recurrently, but the evolutionary significance of its iterative nature is not yet fully understood. Of particular interest are the gene flow dynamics and the mechanisms that allow young sibling polyploids to remain distinct while sharing the same ploidy, heritage and overlapping distribution areas. By using eight highly variable nuclear microsatellites, newly rep
Analytical solutions to 2D depth-averaged (external mode) and fully 3D (internal mode) periodic flows for numerical model testing are presented in this paper. These solutions take into account the effects of the bottom friction, the horizontal turbulent viscosity, and the vertical turbulent viscosity for the case of 3D flow. The key linkage for the modes is the relationship between the bottom fric
To model the heterodinuclear active sites in plant purple acid phosphatases, a mononuclear synthon, [Fe(III)(H(2)IPCPMP)(Cl(2))][PF(6)] (1), has been generated in situ from the ligand 2-(N-isopropyl-N-((2-pyridyl)methyl)aminomethyl)-6-(N-(carboxylmethyl)-N-((2-pyridyl)methyl)amino methyl)-4-methylphenol (IPCPMP) and used to synthesize heterodinuclear complexes of the formulas [Fe(III)M(II)(IPCPMP)
This essay discusses language uniformity and diversity in the light of recent development of the minimalist program (Hauser et al. 2002, Chomsky 2008, Berwick and Chomsky 2011, and much related work). It pursues two leading ideas. First, Universal Grammar (UG) is maximally minimal: hence early internal language (I-language) is largely uniform across individuals, language variation being mainly or
The activated sludge process can be modelled by ordinary and partial differential equations for the biological reactors and secondary settlers, respectively. Because of the complexity of such a system, simulation models are most often used to investigate them. However, simulation models cannot give general rules on how to control a complex nonlinear process. For a reduced-order model with only two
Blanket peatlands are rain-fed mires that cover the landscape almost regardless of topography. The geographical extent of this type of peatland is highly sensitive to climate. We applied a global process-based bioclimatic envelope model, PeatStash, to predict the distribution of British blanket peatlands. The model captures the present areal extent (Kappa = 0.77) and is highly sensitive to both te
Exposure to extraordinary traumatic experience is one acknowledged risk factor for drug use. We aim to analyse the influence of potentially life-changing childhood stressors, experienced second-hand, on later drug use disorder in a national population of Swedish adolescent and young adults (aged 15-26 years).
Nanocrystalline thin films of PbS are obtained in a straightforward reaction by precipitation at the interface between toluene (containing a Pb precursor) and water (containing Na2S). Lead thiobiuret [Pb(SON(CN(i)Pr-2)(2))(2)] and lead diethyldithiocarbamate [Pb(S2CNEt2)(2)] precursors are used. The films are characterized by X-ray diffraction and electron microscopy, revealing typical particle si
Direct measurements of CO2 fluxes by the eddy covariance method have demonstrated that the examined middle-taiga pine forest, raised bog, true steppe, and southern tundra along the Yenisei meridian (similar to 90 degrees E) are carbon sinks of different capacities according to annual output. The tundra acts as a carbon sink starting from June; forest and bog, from May; and steppe, from the end of
pH is an important factor determining bacterial community composition in soil and water. We have directly determined the community tolerance (trait variation) to pH in communities from 22 lakes and streams ranging in pH from 4 to 9 using a growth based method not relying on distinguishing between individual populations. pH in the water samples was altered to up to 16 pH values, covering in situ pH
