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Social capital, the miniaturization of community and high alcohol consumption: a population-based study

Aims: To study the impact of social participation, trust, and the miniaturization of community, i.e. high social participation/low trust, on the risk of high alcohol consumption. Methods: The Scania 2000 public health survey is a cross-sectional, postal questionnaire study. A total of 13 604 persons aged 18–80 years were included. A logistic regression model was used to investigate the association

The septohippocampal cholinergic system and spatial working memory in the Morris water maze.

The objective of the present study was to determine whether a systematic optimization of Morris water maze (mwm) testing parameters could reveal a significant role of the septohippocampal cholinergic system in spatial working memory. Young adult rats were lesioned using 192 IgG-saporin infused bilaterally into the medial septum. Lesions were near complete as measured by choline acetyltransferase (

A diet based on wheat bread baked with lactic acid improves glucose tolerance in hyperinsulinaemic Zucker (fa/fa) rats

In the present study, the objective was to evaluate the long-term metabolic impact of adding lactic acid to a bread-based diet in obese, hyperinsulinaemic Zucker (fa/fa) rats. All diets were based on a white wheat bread, and the lactic acid was added either prior to, or after the baking process. In addition, a diet with addition of Lactobacillus plantarum 299v was included to investigate the possi

Real-time detection of cofactor availability in genetically modified living Saccharomyces cerevisiae cells - Simultaneous probing of different geno- and phenotypes.

This work describes a mediated amperometric method for simultaneous real-time probing of the NAD(P)H availability in two different phenotypes, fermentative and respiratory, of the phosphoglucose isomerase deletion mutant strain of S. cerevisiae, EBY44 [ENY.WA-1A pgi1-1D::URA3], and its parental strain, ENY.WA-1A. The developed method is based on multichannel detection using microelectrode arrays.

Effects of factor Xa and protein S on the individual activated protein C-mediated cleavages of coagulation factor Va.

Activated protein C inhibits the procoagulant function of activated factor V (FVa) through proteolytic cleavages at Arg-306, Arg-506, and Arg-679. The cleavage at Arg-506 is kinetically favored but protected by factor Xa (FXa). Protein S has been suggested to annihilate the inhibitory effect of FXa, a proposal that has been challenged. To elucidate the effects of FXa and protein S on the individua

Prostate-specific antigen and prostate cancer: prediction, detection and monitoring

Testing for prostate-specific antigen ( PSA) has profoundly affected the diagnosis and treatment of prostate cancer. PSA testing has enabled physicians to detect prostate tumours while they are still small, low-grade and localized. This very ability has, however, created controversy over whether we are now diagnosing and treating insignificant cancers. PSA testing has also transformed the monitori

Thin semitransparent gels containing phenylboronic acid: porosity, optical response and permeability for sugars.

Radical copolymerization of acrylamide (Am) (90 mol%) with N-acryloyl-m-aminophenylboronic acid (NAAPBA) (10 mol%) carried out on the surface of glass slides in aqueous solution and in the absence of chemical cross-linkers, resulted in the formation of thin semitransparent gels. The phenylboronic acid (PBA) ligand density was ca. 160 micromol/ml gel. The gels exhibited a macroporous structure and

Extra-pair fertilizations in the Sedge Warbler

Parentage of 201 young (from 44 broods) in a population of Sedge Warblers Acrocephalus schoenobaenus in South Central Sweden, 1990-1992, was determined by using multilocus DNA fingerprinting. The frequency of extra-pair young (EPY) was 7.5% and they occurred in 23% of the broods. For 11 out of 15 extra-pair young we could identify the true father; in all of the cases he was a close neighbour. Amon

The X-ray source population of the globular cluster M15: Chandra high-resolution imaging

The globular cluster M15 was observed on three occasions with the High Resolution Camera on- board Chandra in 2001 in order to investigate the X- ray source population in the cluster centre. After subtraction of the two bright central sources, four faint sources were identified within 50 arcsec of the core. One of these sources is probably the planetary nebula K648, making this the first positive

Peer assistance for personal assistance: Analysis of online discussions about personal assistance from a Swedish web forum for disabled people

This paper describes and analyses a community of disabled people in Sweden that use an online forum to discuss personal assistance issues. The forum is a community of practice (CoP) that has its roots in everyday living with personal assistance. The contributions to the forum were studied over a 41/2 year period, including a total of 2755 postings from 146 persons. The levels of the CoP learning s

Onset of pi(0) Suppression Studied in Cu plus Cu Collisions at root s(NN)=22.4, 62.4, and 200 GeV

Neutral pion transverse momentum (p(T)) spectra at midrapidity (|y| less than or similar to 0.35) were measured in Cu + Cu collisions at root s(NN) = 22.4, 62.4, and 200 GeV. Relative to pi(0) yields in p + p collisions scaled by the number of inelastic nucleon-nucleon collisions (N-coll) the pi(0) yields for p(T) greater than or similar to 2 GeV/c in central Cu + Cu collisions are suppressed at 6

Studies of arginine-arene interactions through synthesis and evaluation of a series of galectin-binding aromatic lactose esters

Aromatic lactose 2-O-esters were synthesized and used to probe arene-arginine interactions with the galectin family of proteins. They were found to be low mu m inhibitors of galectin-1, -3, and -9N-terminal domain and moderate inhibitors of galectin-7, but not inhibitors of galectin-8N-terminal, which locks an arginine residue close to the critical, esterified lactose 2-O-position. Molecular model

A study of propane ammoxidation on Mo-V-Nb-Te-oxide catalysts diluted with Al2O3, SiO2, and TiO2

Mo-V-Nb-Te-oxide catalysts with nominal metal compositions equal to those of M1, M2, and a mixture of the M1 and M2 phases were prepared in neat and sol-diluted forms. The latter catalysts were prepared with 30 wt% of Al2O3, SiO2, or TiO2 sol. All catalysts were characterized by BET, XRD, and TPR and tested for the respective ammoxidation of propane and propene. XRD showed that dilution with SiO2

Analysis of phase composition in aqueous two-phase systems using a two-column chromatographic method: Application to lactic acid production by extractive fermentation

A new chromatographic system for the simultaneous analysis of polyethylene glycol, dextran, sugars, and low-molecular-weight fatty acids was developed. The system is based on a gel exclusion column which allows a first separation between high- and low-molecular-weight compounds, and a cationic exchange column used to further separate the low-molecular-weight compounds. Two applications of the syst

Antirheumatic gold compounds and penicillamine enhance protein kinase C-mediated activation of the arachidonate-mobilizing phospholipase A2 in mouse macrophages

The effects of antirheumatic gold compounds and D-penicillamine on protein kinase C- and Ca(2+)-mediated activation of arachidonate mobilization and the formation of eicosanoids in mouse macrophages have been investigated. Auranofin (0.2-2 microM) enhanced the response to phorbol ester two- to three-fold, and similar enhancement was caused by aurothiomalate, aurothioglucose, and penicillamine, but

Spinal reflexes provide motor error signals to cerebellar modules - relevance for motor coordination

The cerebellar olivo-cortico-nuclear network influencing rubro- and corticospinal tracts via the nucleus interpositus anterior (NIA) is one of the most thoroughly characterized mammalian motor systems involved in limb movement control. Recent findings indicate that climbing fibres innervating the NIA system mediate highly integrated sensorimotor information derived from spinal withdrawal reflex mo

Microsatellite markers in a complex of Horismenus sp. (Hymenoptera : Eulophidae), parasitoids of bruchid beetles

Parasitoids of the genus Horismenus (Hymenoptera: Eulophidae) are the main natural enemies of bruchid beetles that feed on several species of Phaseolus beans. Samples of Horismenus depressus, H. missouriensis and H. butcheri were collected from seeds of three Phaseolus species throughout Mexico to examine the impact of plant variability on the genetic structure of parasitoid populations. For this

Effects of superimposed electrical stimulation on perceived discomfort and torque increment size and variability.

Superimposed electrical stimulation techniques can be used to detect central activation failure (CAF), that is, incomplete central nervous system recruitment or suboptimal activation of motor units. The purpose of this study was to evaluate the effects of two stimulation parameters on perceived discomfort and torque increment size and variability. Discomfort was evaluated using a visual analog sca