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From the bottom up? Involving knowledge and stakeholders from coastal communities in higher-level governance

How to include knowledge and actors from local and regional levels like small-scale fishers and their communities in overarching governance frameworks? This is a pertinent question for ongoing Blue Economy processes, as highlighted e.g., in the Manifesto from the 2021 MARE conference. In an ongoing “from research to practice” project, we investigate how to include local and regional perspectives a

Balancing between care and control: Staff perception on the introduction of long-acting injectables for opioid agonist treatment

Background:Several previous studies have analyzed patient experiences of long-acting injectable buprenorphine (LAIB) in treating opioid use disorder (OUD). This treatment approach reduces the need for daily supervised clinic visits, but also fundamentally changes the dynamic of the relationship between patients and staff. The perspective of staff working with opioid agonist treatment (OAT) on LAIB

Effectiveness and Safety of the ESC-TROP (European Society of Cardiology 0h/1h Troponin Rule-Out Protocol) Trial

BACKGROUND: European guidelines recommend the use of a 0h/1h hs-cTn (high-sensitivity cardiac troponin) protocol in patients with acute chest pain. We aimed to determine the performance of this protocol in routine care when supplemented with patient history and ECG and a recommendation to refrain from noninvasive testing in low-risk patients.METHODS AND RESULTS: This was a pre- and postimplementat

Dealing With Temporality in Patients With Life-Limiting Disease : An International Qualitative Study

The prospect of death influences people’s thoughts about and how they deal with their remaining time. We aimed to understand whether patients with progressive, life-limiting diseases are oriented in the past, present, or future and how they deal with temporality. We conducted 57 in-depth interviews with end-of-life patients in 10 countries using thematic analysis at three levels (i.e., locally in

On the Characteristic Polynomial of the Eigenvalue Moduli of Random Normal Matrices

We study the characteristic polynomial pn(x)=∏j=1n(|zj|-x) where the zj are drawn from the Mittag–Leffler ensemble, i.e. a two-dimensional determinantal point process which generalizes the Ginibre point process. We obtain precise large n asymptotics for the moment generating function E[euπIm\,lnpn(r)eaRe\,lnpn(r)], in the case where r is in the bulk, u ϵ R and a ϵ N. This expectation involves an n

Intergovernmental Relations and Refugee Language Training in Finland and Sweden : A Conflicted Policy Process

This paper discusses how language training for refugees is implemented by the local authorities in Finland and Sweden. The responsibility, production and financing of this specific integration service, language training, is distributed over a multitude of actors in a multidimensional governance structure. We apply a conceptual framework based on intergovernmental relations and conflictual policy p

Identification and validation of novel engineered AAV capsid variants targeting human glia

Direct neural conversion of endogenous non-neuronal cells, such as resident glia, into therapeutic neurons has emerged as a promising strategy for brain repair, aiming to restore lost or damaged neurons. Proof-of-concept has been obtained from animal studies, yet these models do not efficiently recapitulate the complexity of the human brain, and further refinement is necessary before clinical tran

Revisiting Andrews method and grain boundary resistivity from a computational multiscale perspective

The effective material response as observed at a macro level is a manifestation of the material microstructure and lower scale processes. Due to their distinct atomic arrangement, compared to bulk material, grain boundaries significantly affect the electrical properties of metals. However, a scale-bridging understanding of the associated microstructure–property relation remains elusive so that phe

Heritability of cough across two generations : the RHINESSA study

Aim Heritability of cough has not yet been studied. We aimed to evaluate if individuals with cough are more likely to have offspring who develop cough, and if these associations differ by type of cough (productive/nonproductive). Methods The RHINESSA Generation Study (Respiratory Health In Northern Europe, Spain and Australia) includes 7155 parents (initially aged 30–54) answering detailed questio

A (sub)field guide to quality control in hippocampal subfield segmentation on high-resolution T2-weighted MRI.

Inquiries into properties of brain structure and function have progressed due to developments in magnetic resonance imaging (MRI). To sustain progress in investigating and quantifying neuroanatomical details in vivo, the reliability and validity of brain measurements are paramount. Quality control (QC) is a set of procedures for mitigating errors and ensuring the validity and reliability of brain

The International Anticorruption Agenda, Legal Culture, and Business Environment in Uzbekistan

This chapter aims to examine the impact of the international anticorruption agenda on the business and investment climate and legal culture in Uzbekistan. In undertaking this task, I specifically emphasise the daily life of anticorruption laws, policies, and agencies in Uzbekistan in order to understand how domestic institutions and actors perceive, interpret, negotiate, and challenge global antic

Long-term effects of cholinesterase inhibitors and memantine on cognitive decline, cardiovascular events, and mortality in dementia with Lewy bodies : An up to 10-year follow-up study

INTRODUCTION: We aimed to assess the impact of cholinesterase inhibitors (ChEIs) and memantine on cognition, major adverse cardiovascular events (MACE) and mortality in dementia with Lewy bodies (DLB). METHODS: A total of 1,095 incident DLB patients from the Swedish Registry on cognitive/dementia disorders were included. Using an inverse probability of treatment weighting, the effect of initiating

Prior exposure to alkylating agents negatively impacts testicular organoid formation in cells obtained from childhood cancer patients

STUDY QUESTION: Can human pre- and peri-pubertal testicular cells obtained from childhood cancer patients, previously treated with chemotherapy, form testicular organoids (TOs)? SUMMARY ANSWER: Organoid formation from testicular tissue collected from childhood cancer patients positively correlates with SRY-Box transcription factor 9 (SOX9) expression in Sertoli cells, which in turn negatively corr