OBJECTIVE: One-hour plasma glucose (1-h PG) during the oral glucose tolerance test (OGTT) is an accurate predictor of type 2 diabetes. We performed a meta-analysis to determine the optimum cutoff of 1-h PG for detection of type 2 diabetes using 2-h PG as the gold standard. RESEARCH DESIGN AND METHODS: We included 15 studies with 35,551 participants from multiple ethnic groups (53.8% Caucasian) and

Unilateral traumatic brain injury and stroke result in asymmetric postural and motor deficits including contralateral hemiplegia and hemiparesis. In animals, a localized unilateral brain injury recapitulates the human upper motor neuron syndrome in the formation of hindlimb postural asymmetry with contralesional limb flexion and the asymmetry of hindlimb nociceptive withdrawal reflexes. The curren

Pharmaceuticals that are not completely metabolized in the human body are excreted in wastewater and may find their way into surface waters, where they can have harmful effects on aquatic fauna and flora. The implementation of ozonation at wastewater treatment plants (WWTPs) can reduce the amount of pharmaceuticals discharged to the environment. Despite the technology readiness level of ozone trea

We study the adsorption of water onto deposited inorganic sodium chloride and organic malonic acid and sucrose nanoparticles at ambient water pressures corresponding to relative humidities (RH) from 0 % to 16 %. To obtain information about water adsorption at conditions which are not accessible with typical aerosol instrumentation, we use surface-sensitive ambient pressure X-ray photoelectron spec

Soft X-ray absorption and emission spectra of glycine betaine (GB) have been measured at the O K-edge in neutral and strongly acidic solutions. The absorption spectra of the neutral solutions have a resonance peak at 532.6 eV, assigned to the transition to the π∗ orbital, whereas in the acidic solutions, the peak is shifted by -0.3 eV. The emission spectra taken as a function of the GB concentrati

Allergic rhinitis is an inflammation in the nose caused by overreaction of the immune system to allergens in the air. Managing allergic rhinitis symptoms is challenging and requires timely intervention. The following are major questions often posed by those with allergic rhinitis: How should I prepare for the forthcoming season? How will the season's severity develop over the years? No country yet

The El Niño - Southern Oscillation (ENSO) influences the global climate and the variability in the terrestrial carbon cycle on interannual timescales. Two different expressions of El Niño have recently been identified: (i) central Pacific (CP) and (ii) eastern Pacific (EP). Both types of El Niño are characterised by above-average sea surface temperature anomalies at the respective locations. Studi

The process of hematopoiesis is subject to substantial ontogenic remodeling that is accompanied by alterations in cellular fate during both development and disease. We combine state-of-the-art mass spectrometry with extensive functional assays to gain insight into ontogeny-specific proteomic mechanisms regulating hematopoiesis. Through deep coverage of the cellular proteome of fetal and adult lymp

Lignin is one of the three predominant biopolymers that make up plants together with cellulose and hemicellulose, and it is the only plant component that is based on aromatic units. The industrial kraft pulping process generates large amounts of lignin, which is currently used to generate heat for the process. The subject of this thesis is the valorization of kraft lignin into valuable chemicals.

Cell therapy for Parkinson's disease (PD) is aimed to replace the degenerated midbrain dopamine (mDA) neurons and restore DA neurotransmission in the denervated forebrain targets. A limitation of the intrastriatal grafting approach, which is currently used in clinical trials, is that the mDA neurons are implanted into the target area, in most cases the putamen, and not in the ventral midbrain wher

Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.

It is unknown how many mantle cell lymphoma (MCL) patients undergo consolidation with autologous hematopoietic cell transplantation (AHCT), and the reasons governing the decision, are also unknown. The prognostic impact of omitting AHCT is also understudied. We identified all MCL patients diagnosed from 2000 to 2014, aged 18 to 65 years, in the Swedish Lymphoma Register. Odds ratios (ORs) and 95%

H+ modulated charge-transfer in photoexcited covalent polyoxometalate-bodipy conjugates is described. The hybrid organic/inorganic molecular photoactive dyads are based on Keggin-type polyoxometalates (POMs, where KM = [PM11O39] and M = Mo or W) covalently grafted via an organotin linker to a bodipy (BOD) photosensitizer. The relative potentials of the photosensitizer and POM are aligned such that

Twenty years since the adoption of UN Security Council Resolution 1325 there is an almost unanimous call for an increased number of uniformed women in peace operations from policy-makers and multilateral organizations. This continuous push for the inclusion of more women is often justified by arguments about an increased operational effectiveness related to women's ‘added value’: both implicitly a

Nils-Eric Sahlin och Sylvia Schwaag Serger diskuterar i kapitel tre hur forskare har interagerat med beslutsfattare under krisen och presenterar principer som syftar till att förbättra samspelet mellan vetenskap och politik.

This study focuses on soldiers returning from peacekeeping missions and the challenges they experience adapting to the home environment in the postdeployment phase. The article focuses on South African peacekeepers returning from missions in Darfur/Sudan, the Democratic Republic of Congo, and Burundi. Interviews with 50 South African peacekeepers on the challenges they face in terms of their homec

Taking a deep look at how China has transformed its capacity for scientific research and innovation provides a window into the country’s ambitions and possible paths in the future.

Samhällsvetenskapen gör samtiden begriplig. Genom att kritiskt granska politik, ekonomi, kommunikation och organisation ger den djupare förståelse för det moderna samhällets förtjänster och problem. Dock bara om den utförs väl, och på allvar tillåts skärskåda gängse föreställningar och företeelser. Under fem övergripande rubriker: Kritisk, Kvalitativ, Konsekvensneutral, Krävande och Konstruktiv, v