Search results

Filter

Filetype

Your search for "*" yielded 528644 hits

Gain-of-function induced defects by PITX2 in eye and limb development

My research has been focused on eye and limb development with regard to the transcription factor PITX2. In the first paper we present an Axenfeld-Rieger syndrome PITX2 gain-of-function eye mouse model. Axenfeld-Rieger syndrome is a rare autosomal disorder affecting the development of eyes, teeth and abdomen. The eye defects consist of anomalies in the anterior segment. In addition, almost 50% of A

Tumor markers in prostate cancer I: Blood-based markers

The introduction of total prostate specific antigen (total PSA) testing in blood has revolutionized the detection and management of men with prostate cancer (PCa). The objective of this review was to discuss the challenges of PCa biomarker research, definition of the type of PCa biomarkers, the statistical considerations for biomarker discovery and validation, and to review the literature regardin

Analysis of viscoelastic soft dielectric elastomer generators operating in an electrical circuit

A predicting model for soft dielectric elastomer generators (DEGs) must consider a realistic model of the electromechanical behaviour of the elastomer filling, the variable capacitor and of the electrical circuit connecting all elements of the device. In this paper such an objective is achieved by proposing a framework for reliable simulations of soft energy harvesters. In particular, a simple ele

Tortured refugees' expectations of a multidisciplinary pain rehabilitation programme: An explorative qualitative study

Background: Refugees have often been exposed to torture in their countries of origin. Rehabilitation of tortured refugees living in Denmark is offered by the specialized Rehabilitation and Research Centre for Torture Victims in Copenhagen. After an interdisciplinary assessment eligible patients are recommended rehabilitation. Objective: To explore tortured refugees' expectations of the multidiscip

Factors associated with high use of a workplace web-based stress management program in a randomized controlled intervention study.

In web-based health promotion programs, large variations in participant engagement are common. The aim was to investigate determinants of high use of a worksite self-help web-based program for stress management. Two versions of the program were offered to randomly selected departments in IT and media companies. A static version of the program including health screening tool, diary and information

Model Reduction Using Semidefinite Programming

In this thesis model reduction methods for linear time invariant systems are investigated. The reduced models are computed using semidefinite programming. Two ways of imposing the stability constraint are considered. However, both approaches add a positivity constraint to the program. The input to the algorithms is a number of frequency response samples of the original model. This makes the comput

Small x, Saturation, and Diffraction in Collisions with Electrons, Protons and Nuclei

The Lund dipole model DIPSY is based on BFKL evolution and saturation. It can be applied to collisions between electrons, protons, and nuclei. In this paper, I present some recent results for exclusive final states in inelastic collisions, a method to generate final states in diffractive excitation, and some results for collisions with nuclei.

Better Prognosis of Patients with Glioma Expressing FGF2-Dependent PDGFRA Irrespective of Morphological Diagnosis.

Signaling of platelet derived growth factor receptor alpha (PDGFRA) is critically involved in the development of gliomas. However, the clinical relevance of PDGFRA expression in glioma subtypes and the mechanisms of PDGFRA expression in gliomas have been controversial. Under the supervision of morphological diagnosis, analysis of the GSE16011 and the Repository of Molecular Brain Neoplasia Data (R

Treatment of landfill leachate by irrigation of willow coppice - Plant response and treatment efficiency

Landfill leachates usually need to be treated before discharged. and using soil-plant systems for this has gained substantial interest in Sweden and in the UK A three-year field study was conducted in central Sweden to quantify plant response, treatment efficiency and impact on groundwater quality of landfill leachate irrigation of short-rotation willow coppice (Salix) Two willow varieties were te

Frequency-modulated light scattering interferometry employed for optical properties and dynamics studies of turbid media.

In the present work, fiber-based frequency-modulated light scattering interferometry (FMLSI) is developed and employed for studies of optical properties and dynamics in liquid phantoms made from Intralipid(®). The fiber-based FMLSI system retrieves the optical properties by examining the intensity fluctuations through the turbid medium in a heterodyne detection scheme using a continuous-wave frequ

Measurement of the inclusive e(+/-) p scattering cross section at high inelasticity y and of the structure function F-L

A measurement is presented of the inclusive neutral current e(+/-) p scattering cross section using data collected by the H1 experiment at HERA during the years 2003 to 2007 with proton beam energies E-p of 920, 575, and 460 GeV. The kinematic range of the measurement covers low absolute four-momentum transfers squared, 1.5 GeV2 < Q(2) < 120 GeV2, small values of Bjorken x, 2.9 . 10(-5) < x < 0.01

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

Consistent but indirect evidence has implicated genetic factors in smoking behavior1,2. We report meta-analyses of several smoking phenotypes within cohorts of the Tobacco and Genetics Consortium (n = 74,053). We also partnered with the European Network of Genetic and Genomic Epidemiology (ENGAGE) and Oxford-GlaxoSmithKline (Ox-GSK) consortia to follow up the 15 most significant regions (n > 140,0

Improving student success in difficult engineering education courses through Supplemental Instruction (SI) – what is the impact of the degree of SI attendance?

The customary way to determine whether an adopted Supplemental Instruction (SI) program has been successful or not is by comparing course results for two groups, SI attendees and non-attendees. The division of SI attendees and non-attendees is generally done rather arbitrarily by prescribing a minimum number of SI sessions a student has to attend to be considered an SI attendee. Although the SI at

A Proposal for a Comprehensive Grading of Parkinson's Disease Severity Combining Motor and Non-Motor Assessments: Meeting an Unmet Need

Background: Non-motor symptoms are present in Parkinson's disease (PD) and a key determinant of quality of life. The Non-motor Symptoms Scale (NMSS) is a validated scale that allows quantifying frequency and severity (burden) of NMS. We report a proposal for using NMSS scores to determine levels of NMS burden (NMSB) and to complete PD patient classification. Methods: This was an observational, cro

Tumour markers in prostate cancer III: Biomarkers in urine

The serum PSA test still is the most important biomarker for the detection and follow-up of prostate cancer. PSA-based screening can reduce disease specific mortality but coinciding unnecessary testing and overdiagnosis warrant further research for more specific biomarkers. Numerous studies of both serum and urine-based prostate cancer biomarker candidates have been presented the last ten years. H

Mutations in components of complement influence the outcome of Factor I-associated atypical hemolytic uremic syndrome

Genetic studies have shown that mutations of complement inhibitors such as membrane cofactor protein, Factors H, I, or B and C3 predispose patients to atypical hemolytic uremic syndrome (aHUS). Factor I is a circulating serine protease that inhibits complement by degrading C3b and up to now only a few mutations in the CFI gene have been characterized. In a large cohort of 202 patients with aHUS, w