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The pathophysiologic mechanisms in type 1 diabetes (T1DM) involve loss of islet β-cell secretory function caused by selective killing of these cells primarily by aggressive autoimmune responses involving both cellular and humoral immune pathways. Inflammatory cells heavily infiltrate pancreatic islets leading to insulitis where CD8+ T lymphocytes are thought to be responsible for selective and spec
We report on preliminary results from time-resolved optical spectroscopy of the He-rich variable white dwarf GD 358.
Abstract is not available
The aim of this book is to improve our understanding of creative knowledge environments. The various chapters analyse creative and innovate activities as carried out by individuals, groups and organisations. The book’s focus is on identifying and understanding the factors relating to the working environment that are conducive to human creativity and innovation. The editing of the book has been a c
In Sweden, accident statistics reveal little, if any, evidence of improvement in health and safety on construction sites. Accident statistics, which adopt a reactive approach, must not be looked upon as merely numbers and figures. They must be able to reveal the underlying factors contributing to the accidents. This paper aims to examine construction safety performance based on accidents data from
The aim of this work is to investigate the internal dynamics of power-exercising in compulsory school and wage labor. The exercise of power is structured by four interrelated power-practices: maintenance, that is the practice which produce and reproduce a power relation through, among other things, the enrolment of subordinates; acculturation, the alteration-of-man power that is exercised inside t
Douglas Portmores förslag på hur vi skall skilja mellan agent-neutrala och agent-relativa skäl disktureras. Enligt förslaget utgörs normativa skäl av en särskild typ av så kallade konjunktiva fakta – dvs. sådana sakförhållanden som råder enligt sanna kontrafaktiska utsagor. Ansatsen är lovande. Emellertid, det också finns en del otydligheter med förslaget som behöver närmare utredas. Uppsatsen lyf
The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into
A high fat intake, together with an inability to match lipid utilization of a high-fat intake, is correlated with obesity in man. In this review enterostatin, a peptide, which specifically reduces fat intake, is described. Enterostatin is formed in the intestine by the cleavage of pancreatic procolipase, the remaining colipase serving as an obligatory cofactor for pancreatic lipase during fat dige
