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Seasonal changes of leachate production and quality from test cells

Seasonal changes oi leachate production and water-flux-dependent leachate quality from two test cells containing 4,000 t of refuse each were investigated. Pronounced seasonal dependence of the leachate production appeared three years after the final covering of the test cells. With seasonal dependent production, a number of leachate parameters showed water-Aux-dependent trends. The dependence was

Capturing ion exchanger-bound infectious pancreatic necrosis virus - design and application for large volume water samples

A method was designed for rapid and reliable demonstration of the presence of infectious pancreatic necrosis virus retrieved from 5 1 water samples. Viruses together with an added carrier protein were adsorbed to a resin of an added anion exchanger. Then the resin was collected rapidly and quantitatively through a specific device which we designed. The resin was transferred to a column from which

Detection of methane with mid-infrared polarization spectroscopy

We report on the application of polarization spectroscopy in the midinfrared spectral region for the detection of methane by probing its asymmetric ro-vibrational transitions. Tunable infrared laser radiation, near 3.4 mum, was obtained from difference-frequency generation in a LiNbO3 crystal. Infrared polarization spectroscopy (IRPS) spectra of the P, Q and R branches of the nu(3) band, recorded

The opitz syndrome gene mid1 is transcribed from a human endogenous retroviral promoter.

Human endogenous retroviruses (HERVs) and other long terminal repeat (LTR)–containing elements comprise a significant portion (8%) of the human genome and are likely vestiges of retroviral infections during primate evolution. Many of the HERVs present in human DNA have retained functional promoter, enhancer, and polyadenylation signals, and these regulatory sequences have the potential to modify t

Simplified vehicle calibration using multilinear constraints

An Autonomously Guided Vehicle using both odometry and visual data for navigation needs calibration parameters. These include camera placement as well as parameters relating odometry to vehicle motion. Calibration of these parameters is related to the Hand-Eye calibration problem. Instead of using a calibration target or trying to solve for structure and motion a novel method using the continuous

Average force along unbonded tendons: a field study at nuclear reactor containments in Sweden

The tightness and integrity of all Swedish reactor containments depend directly and indirectly on the function of the post-tensioned system. The tendon force in containments with unbonded tendons is followed up at regular in-service inspections (ISI) to ensure that the remaining force is sufficient. At the inspections, the tendon force is measured with so-called lift-off technique, where a jack is

The T allele of rs7903146 TCF7L2 is associated with impaired insulinotropic action of incretin hormones, reduced 24 h profiles of plasma insulin and glucagon, and increased hepatic glucose production in young healthy men

We studied the physiological, metabolic and hormonal mechanisms underlying the elevated risk of type 2 diabetes in carriers of TCF7L2 gene. We undertook genotyping of 81 healthy young Danish men for rs7903146 of TCF7L2 and carried out various beta cell tests including: 24 h glucose, insulin and glucagon profiles; OGTT; mixed meal test; IVGTT; hyperglycaemic clamp with co-infusion of glucagon-like

Glycolipid depletion in antimicrobial therapy

Mucosal pathogens target sites of infection through specific adherence to host glycoconjugate receptors. As a consequence, depletion of such receptors from the cell surface may be expected to inhibit attachment, impair bacterial colonization and reduce the activation of mucosal inflammation. We have used the glucose analogue and glycosphingolipid (GSL) biosynthesis inhibitor N-butyldeoxynojirimyci

Selective induction of inducible nitric oxide synthase in pancreatic islet of rat after an intravenous glucose or intralipid challenge.

Objective: Constant exposure of pancreatic islets to high levels of glucose or free fatty acids can lead to irreversible beta-cell dysfunction, a process referred to as glucotoxicity or lipotoxicity, respectively. In this context a role for nitric oxide generated by pancreatic islet has been suggested. The present investigation examined whether the route of glucose administration, i.e., given oral

Update on the pathophysiology and classification of von Willebrand disease: a report of the Subcommittee on von Willebrand Factor

von Willebrand disease (VWD) is a bleeding disorder caused by inherited defects in the concentration, structure, or function of von Willebrand factor (VWF). VWD is classified into three primary categories. Type 1 includes partial quantitative deficiency, type 2 includes qualitative defects, and type 3 includes virtually complete deficiency of VWF. VWD type 2 is divided into four secondary categori

Low temperature Ga surface diffusion from focused ion beam milled grooves.

Ga diffusion from focused ion beam (FIB) milled grooves has been studied using x-ray photoemission electron microscopy (XPEEM) and mirror electron microscopy (MEM). We analyze the surface chemistry of the FIB structures measuring the Ga presence in the top layers of the milled grooves and morphological defects inside the grooves. The Ga is initially strictly confined to the grooves. However, annea

BDNF downregulates 5-HT2A receptor protein levels in hippocampal cultures

Both brain-derived neurotrophic factor (BDNF) and the serotonin receptor 2A (5-HT2A) have been related to depression pathology. Specific 5-HT2A receptor changes seen in BDNF conditional mutant mice suggest that BDNF regulates the 5-HT2A receptor level. Here we show a direct effect of BDNF on 5-HT2A receptor protein levels in primary hippocampal neuronal and mature hippocampal organotypic cultures

Equilibrium sampling through membranes of freely dissolved chlorophenols in water samples with hollow fiber supported liquid membrane

The freely dissolved concentration (C-free) of pollutants is generally believed to be bioavailable and thus responsible for toxic effects. The C-free of organic weak acids and bases consists of a dissociated and a nondissociated fraction. By using chlorophenols as model compounds, a negligible-depletion extraction technique, equilibrium sampling through membranes (ESTM), was developed for the meas

Hypoxia-inducible factors 1 and 2 are important transcriptional effectors in primary macrophages experiencing hypoxia

Ischemia exists in many diseased tissues, including arthritic joints, atherosclerotic plaques, and malignant tumors. Macrophages accumulate in these sites and up-regulate hypoxia-inducible transcription factors (HIFs) 1 and 2 in response to the hypoxia present. Here we show that the gene expression profile in primary human and murine macrophages changes markedly when they are exposed to hypoxia fo

Deep sea records from the southeast Labrador Sea: Ocean circulation changes and ice-rafting events during the last 160,000 years

[1] Results from two deep sea cores from northeast of Newfoundland at 1251 and 2527 m water depth, respectively, indicate that during the time period from 160,000 to 10,000 years BP, ice rafting events in the Labrador Sea were accompanied by rapid variations in deep and surface water circulation. Twelve ice-rafting events occurred, each coinciding with high concentrations of detrital carbonate and