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Comparison between interstitial laser thermotherapy and excision of an adenocarcinoma transplanted into rat liver
The aim of this study was to compare interstitial laser thermotherapy with excision of a liver tumour. A dimethylhydrazine-induced adenocarcinoma was transplanted (implanted if not stated otherwise) into the left lateral lobe of the rat liver, and treatment was performed 8 days later. In the main experiment, rats were treated with resection of the tumour-bearing robe or underwent interstitial lase
Insulin inhibits glucagon release by SGLT2-induced stimulation of somatostatin secretion
Hypoglycaemia (low plasma glucose) is a serious and potentially fatal complication of insulin-treated diabetes. In healthy individuals, hypoglycaemia triggers glucagon secretion, which restores normal plasma glucose levels by stimulation of hepatic glucose production. This counterregulatory mechanism is impaired in diabetes. Here we show in mice that therapeutic concentrations of insulin inhibit g
Monitoring real-time hormone release kinetics via high-content 3-D imaging of compensatory endocytosis
High-content real-time imaging of hormone secretion in tissues or cell populations is a challenging task, which is unlikely to be resolved directly, despite immense translational value. We approach this problem indirectly, using compensatory endocytosis, a process that closely follows exocytosis in the cell, as a surrogate read-out for secretion. The tissue is immobilized in an open-air perifusion
Dispersion-free interferometric autocorrelator for measurement of ultra-broadband pulses
We demonstrate a dispersion-free split mirror interferometric autocorrelator suitable for measuring pulses with durations from hundreds of attoseconds to tens of femtoseconds and spectral content from the near-UV to near-IR.
Focused laser intensity measurement at 1018 W/cm2 and 1053 nm
We present a simple experimental setup that makes possible the measurement of the beam section at focus under full-power conditions. We demonstrate that a 1.5-TW laser system can be focused down to a 13.5-μm-diameter spot using conventional lens focalization, thus achieving laser intensities of up to 1018 W/cm2.
The N680S variant in the follicle-stimulating hormone receptor gene identifies hyperresponders to controlled ovarian stimulation
OBJECTIVE: To study if the follicle-stimulating hormone receptor (FSHR) variant asparagine/serine in amino acid 680 (N680S) can predict hypersensitivity to gonadotropins in women undergoing assisted reproduction.PATIENTS AND METHODS: In this retrospective study, 586 women undergoing their first in-vitro fertilisation treatment were enroled, and their FSHR N680S genetic variant was analysed. The ma
KASAM-instrumentets utveckling och psychometriska egenskaper - en översikt.
The Sense of Coherence scale (SOC) is a widely used instrument in medical research as well as in other research areas. The Sense of Coherenceis assumed as a useful concept in assessing an individual’s orientation to life and internal strengths. However, despite the frequent use in vari-ous research studies and several psychometric evaluations there is no unequivocal evidence for its validity and r
Reweighting Parton Showers
Bernard Williams: Ethics from a Human Point of View
Free Will Pessimism
[Review of] 'Conversation and Responsibility', by Michael McKenna
Toolbox: : Operationalising Telecoupling using Network Analysis
Voice evaluation before and after laser excision vs. Radiotherapy of t1a glottic carcinoma
Quality of voice after treatment for T1A glottic squamous cell carcinoma was studied in two matched groups of males treated either with CO2 laser cordectomi (n = 18, mean age 65.2 years) or with full dose radiotherapy (n = 18, mean age 65.1 years). All patients had histologically verified invasive squamous cell carcinoma. Fifteen male patients (mean age 63.9 years) without laryngeal disorders were
Cell density dependent uptake of LDL in cultured hepatocytes
An inverse relationship between low-density lipoprotein uptake and cell density was observed in rat hepatocyte monolayers incubated with lipoprotein-deficient serum. This was also true for cell association, binding and degradation of low-density lipoproteins. Compactin stimulated cell association and degradation of low-density lipoproteins both at low and high concentrations. Insulin, on the other