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Background. The incidence and impact of postoperative complications are poorly described. Failure-to-rescue, the rate ofdeath following complications, is an important quality measure for perioperative care but has not been investigated acrossmultiple health care systems.Methods. We analysed data collected during the International Surgical Outcomes Study, an international 7-day cohort studyof adult

BACKGROUND Currently used pre-operative prediction scores for postoperative pulmonary complications (PPCs) use patient data and expected surgery characteristics exclusively. However, intra-operative events are also associated with the development of PPCs. OBJECTIVE We aimed to develop a new prediction score for PPCs that uses both pre-operative and intra-operative data. DESIGN This is a secon

In this paper, we develop a new extension of the singular spectrum analysis (SSA) called functional SSA to analyze functional time series. The new methodology is constructed by integrating ideas from functional data analysis and univariate SSA. Specifically, we introduce a trajectory operator in the functional world, which is equivalent to the trajectory matrix in the regular SSA. In the regular S

Ammonia (NH3) is regarded as an important nitrogen oxides (NOx) precursor and also as an effective reductant for NOx removal in energy utilization through combustion, and it has recently become an attractive non-carbon alternative fuel. To have a better understanding of thermochemical properties of NH3, accurate in situ detection of NH3 in high temperature environments is desirable. Ultraviolet (U

Apolipoprotein A-I (ApoA-I) of high density lipoproteins (HDLs) is essential for the transportation of cholesterol between peripheral tissues and the liver. However, specific mutations in ApoA-I of HDLs are responsible for a late-onset systemic amyloidosis, the pathological accumulation of protein fibrils in tissues and organs. Carriers of these mutations do not exhibit increased cardiovascular di

Background. Solid organ transplants (SOTs) are life-saving interventions, recently challenged by coronavirus disease 2019 (COVID-19). SOTs require a multistep process, which can be affected by COVID-19 at several phases.Methods. SOT-specialists, COVID-19-specialists, and medical ethicists designed an international survey according to CHERRIES guidelines. Personal opinions about continuing SOTs, sa

Methane and hydrogen-enriched (25 vol% and 50 vol% H2-enriched CH4) methane/air premixed flames were investigated in a gas turbine model combustor under atmospheric conditions. The flame operability ranges were mapped at different Reynold numbers (Re), showing the dependence on Re and H2 concentrations. The effects of equivalence ratio (Φ), Re, and H2 enrichment on flame structure were examined em

Aims: Accurate and reliable diagnosis is essential for lung cancer treatment. The study aim was to investigate interpathologist diagnostic concordance for pulmonary tumours according to WHO diagnostic criteria. Methods: Fifty-two unselected lung and bronchial biopsies were diagnosed by a thoracic pathologist based on a broad spectrum of immunohistochemical (IHC) stainings, molecular data and clini

Purpose: In 2017, the Geneva Alzheimer’s disease (AD) Biomarker Roadmap initiative adapted the framework of the systematic validation of oncological diagnostic biomarkers to AD biomarkers, with the aim to accelerate their development and implementation in clinical practice. With this work, we assess the maturity of [18F]flortaucipir PET and define its research priorities. Methods: The level of mat

The article focuses on the entanglement between the EU’s attempts to construct its external actions in global politics and research on the EU as a global actor. The article argues that both the development of EU external actions and the sociology of knowledge production surrounding the analysis of these actions suffer from unnecessary dichotomisation. Advocates and analysts of the EU’s normative p

In an era of European crises over political legitimacy, economic austerity, and collapse of confidence in the EU the topic of European integration has be-come a very emotional subject. The anger which protestors demonstrate against economic austerity, the hate which nationalist far-right parties express for the EU and fellow Europeans, and the passion with which supporters of the EU argue for grea