The threat of resistant bacteria is an increasing issue that has emphasized the need for therapeutic strategies. One possible drug candidate is the carbohydrate sialic acid, which adorns almost every cell surface on mammalian cells. These so-called glycans (defined as carbohydrate-based polysaccharides) are involved in key cell functions, including cell-to-cell recognition in eukaryotes. Because o

In this paper, we show that a software implementation of IND-CCA-secure Saber key encapsulation mechanism protected by first-order masking and shuffling can be broken by deep learning-based power analysis. Using an ensemble of deep neural networks trained at the profiling stage, we can recover the session key and the secret key from 257 × N and 24 × 257 × N traces, respectively, where N is the num

Rationale: The optimal duration of dual antiplatelet therapy (DAPT) with clopidogrel-aspirin for the large artery atherosclerotic (LAA) stroke subtype has been debated. Aims: To determine whether the 1-year risk of recurrent vascular events could be reduced by a longer duration of DAPT in patients with the LAA stroke subtype. Methods and study design: A total of 4806 participants will be recruited

The advent and popularity of shared electric scooters in many urban areas worldwide offer new opportunities and challenges to be addressed by the research community, especially as far as safety and accessibility issues are concerned. This paper proposes a methodology, based on geofencing technology (i.e., virtual geographic boundaries) to define in which urban areas the speed of shared electric sc

När regeringen, pressad av SD, inte följer ingångna avtal bryter den med svensk tradition. Historiskt har trepartsmodellen haft framgång i att lösa viktiga samhällsproblem. Med staten som opålitlig part riskeras något av det mest svenska vi har, skriver German Bender på den fackföreningsnära tankesmedjan Arena Idé och professor Anders Kjellberg.

A well-defined terminology of fire-related variables is important for correct analyses and supporting knowledge-based decisions regarding the evaluation of building fires at the European level. After developing an overview of current practices for fire statistics in Part I, the terminology used and the data collected by the EU Member States and eight other countries regarding fire incidents, prope

X-ray crystallography and X-ray spectroscopy using X-ray free electron lasers plays an important role in understanding the interplay of structural changes in the protein and the chemical changes at the metal active site of metalloenzymes through their catalytic cycles. As a part of such an effort, we report here our recent development of methods for X-ray absorption spectroscopy (XAS) at XFELs to

In this work we construct a variety of new complex-valued proper biharmonic maps and (2, 1)-harmonic morphisms on Riemannian manifolds with non-trivial geometry. These are solutions to a non-linear system of partial differential equations depending on the geometric data of the manifolds involved.

Cell culturing methods are increasingly used to reduce and replace the use of live animals in biomedical research and chemical toxicity testing. Although live animals are avoided when using cell culturing methods, they often contain animal-derived components of which one of the most commonly used is foetal bovine serum (FBS). FBS is added to cell culture media among other supplements to support ce

Background: Driving automation systems (DAS), including autonomous driving and advanced driver assistance, are an important safety-critical domain. DAS often incorporate perceptions systems that use machine learning (ML) to analyze the vehicle environment. Aims: We explore new or differing requirements engineering (RE) topics and challenges that practitioners experience in this domain. Method: We

As our society ages inexorably, geroscience and research focusing on healthy aging is becoming increasingly urgent. Macroautophagy (referred to as autophagy), a highly conserved process of cellular clearance and rejuvenation has attracted much attention due to its universal role in organismal life and death. Growing evidence points to autophagy process as being one of the key players in the determ